4m3l: Difference between revisions
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New page: '''Unreleased structure''' The entry 4m3l is ON HOLD Authors: Mayans, O., Franke, B. Description: Crystal Structure of the coiled coil domain of MuRF1 |
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==Crystal Structure of the coiled coil domain of MuRF1== | |||
<StructureSection load='4m3l' size='340' side='right'caption='[[4m3l]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4m3l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M3L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m3l OCA], [https://pdbe.org/4m3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m3l RCSB], [https://www.ebi.ac.uk/pdbsum/4m3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m3l ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref> | |||
==See Also== | |||
*[[Mur ligase|Mur ligase]] | |||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Franke B]] | |||
[[Category: Mayans O]] | |||
Latest revision as of 12:23, 1 March 2024
Crystal Structure of the coiled coil domain of MuRF1
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