2xwc: Difference between revisions

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{{Seed}}
[[Image:2xwc.jpg|left|200px]]


<!--
==Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution==
The line below this paragraph, containing "STRUCTURE_2xwc", creates the "Structure Box" on the page.
<StructureSection load='2xwc' size='340' side='right'caption='[[2xwc]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2xwc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xip 2xip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XWC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2xwc|  PDB=2xwc  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xwc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xwc OCA], [https://pdbe.org/2xwc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xwc RCSB], [https://www.ebi.ac.uk/pdbsum/2xwc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xwc ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P73_HUMAN P73_HUMAN] Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.<ref>PMID:11753569</ref> <ref>PMID:10203277</ref> <ref>PMID:18174154</ref>


===CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF HUMAN TP73 REFINED AT 1.8 A RESOLUTION===
==See Also==
 
*[[P73|P73]]
 
== References ==
==About this Structure==
<references/>
2XWC is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xip 2xip]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XWC OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Bullock, A.]]
[[Category: Bountra C]]
[[Category: Canning, P.]]
[[Category: Bullock AN]]
[[Category: Delft, F Von.]]
[[Category: Canning P]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Krojer, T.]]
[[Category: Krojer T]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz JRC]]
[[Category: Ugochukwu, E.]]
[[Category: Ugochukwu E]]
[[Category: Vollmar, M.]]
[[Category: Vollmar M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Zhang, Y.]]
[[Category: Zhang Y]]
[[Category: Dna-binding protein]]
[[Category: Von Delft F]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Nov 18 00:43:56 2010''

Latest revision as of 07:11, 1 May 2024

Crystal structure of the DNA binding domain of human TP73 refined at 1.8 A resolution

2xwc, resolution 1.82Å

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