3p7o: Difference between revisions
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==Rat Insulin Degrading Enzyme (Insulysin) E111F mutant with two bound peptides== | |||
<StructureSection load='3p7o' size='340' side='right'caption='[[3p7o]], [[Resolution|resolution]] 2.14Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3p7o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P7O FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1423Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p7o OCA], [https://pdbe.org/3p7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p7o RCSB], [https://www.ebi.ac.uk/pdbsum/3p7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p7o ProSAT]</span></td></tr> | |||
== | </table> | ||
[[3p7o]] is a 3 chain structure with sequence from [ | == Function == | ||
[https://www.uniprot.org/uniprot/IDE_RAT IDE_RAT] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. | |||
==See Also== | ==See Also== | ||
*[[Insulin- | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Noinaj | [[Category: Noinaj N]] | ||
[[Category: Rodgers | [[Category: Rodgers DW]] | ||
Latest revision as of 10:39, 21 February 2024
Rat Insulin Degrading Enzyme (Insulysin) E111F mutant with two bound peptides
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