4hrf: Difference between revisions
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New page: '''Unreleased structure''' The entry 4hrf is ON HOLD Authors: Lokareddy, K.R., Bhardwaj, A., Cingolani, G. Description: Atomic structure of DUSP26 |
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==Atomic structure of DUSP26== | |||
<StructureSection load='4hrf' size='340' side='right'caption='[[4hrf]], [[Resolution|resolution]] 1.68Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4hrf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HRF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hrf OCA], [https://pdbe.org/4hrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hrf RCSB], [https://www.ebi.ac.uk/pdbsum/4hrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hrf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DUS26_HUMAN DUS26_HUMAN] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).<ref>PMID:15796912</ref> <ref>PMID:16924234</ref> <ref>PMID:17001450</ref> <ref>PMID:16581800</ref> | |||
==See Also== | |||
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | |||
*[[MAP kinase phosphatase|MAP kinase phosphatase]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bhardwaj A]] | |||
[[Category: Cingolani G]] | |||
[[Category: Lokareddy RK]] | |||
