2r4r: Difference between revisions
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==Crystal structure of the human beta2 adrenoceptor== | ==Crystal structure of the human beta2 adrenoceptor== | ||
<StructureSection load='2r4r' size='340' side='right' caption='[[2r4r]], [[Resolution|resolution]] 3.40Å' scene=''> | <StructureSection load='2r4r' size='340' side='right'caption='[[2r4r]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2r4r]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2r4r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. The April 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adrenergic Receptors'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_4 10.2210/rcsb_pdb/mom_2008_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R4R FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r4r OCA], [https://pdbe.org/2r4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r4r RCSB], [https://www.ebi.ac.uk/pdbsum/2r4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r4r ProSAT]</span></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </table> | ||
<table> | == Function == | ||
[https://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4r_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/2r4r_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r4r ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2r4r" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Adrenergic receptor|Adrenergic receptor]] | *[[Adrenergic receptor|Adrenergic receptor]] | ||
*[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]] | |||
*[[G protein-coupled receptor|G protein-coupled receptor]] | *[[G protein-coupled receptor|G protein-coupled receptor]] | ||
*[[Monoclonal | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 37: | Line 40: | ||
[[Category: Adrenergic Receptors]] | [[Category: Adrenergic Receptors]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
[[Category: Burghammer | [[Category: Burghammer M]] | ||
[[Category: Choi | [[Category: Choi HJ]] | ||
[[Category: Edwards | [[Category: Edwards PC]] | ||
[[Category: Fischetti | [[Category: Fischetti RF]] | ||
[[Category: Kobilka | [[Category: Kobilka BK]] | ||
[[Category: Kobilka | [[Category: Kobilka TS]] | ||
[[Category: Rasmussen | [[Category: Rasmussen SGF]] | ||
[[Category: Ratnala | [[Category: Ratnala VR]] | ||
[[Category: Rosenbaum | [[Category: Rosenbaum DM]] | ||
[[Category: Sanishvili | [[Category: Sanishvili R]] | ||
[[Category: Schertler | [[Category: Schertler GF]] | ||
[[Category: Thian | [[Category: Thian FS]] | ||
[[Category: Weis | [[Category: Weis WI]] | ||
Latest revision as of 09:28, 6 November 2024
Crystal structure of the human beta2 adrenoceptor
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