3ncc: Difference between revisions
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==A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor== | ==A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor== | ||
<StructureSection load='3ncc' size='340' side='right' caption='[[3ncc]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3ncc' size='340' side='right'caption='[[3ncc]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ncc]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ncc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NCC FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ncc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ncc OCA], [https://pdbe.org/3ncc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ncc RCSB], [https://www.ebi.ac.uk/pdbsum/3ncc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ncc ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/3ncc_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/3ncc_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ncc ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3ncc" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Prolactin|Prolactin]] | |||
*[[Prolactin receptor|Prolactin receptor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 31: | Line 38: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chayen | [[Category: Large Structures]] | ||
[[Category: Hodsdon | [[Category: Chayen NE]] | ||
[[Category: Keeler | [[Category: Hodsdon ME]] | ||
[[Category: Kulkarni | [[Category: Keeler C]] | ||
[[Category: Lolis | [[Category: Kulkarni MV]] | ||
[[Category: Murphy | [[Category: Lolis EJ]] | ||
[[Category: Myszka | [[Category: Murphy JW]] | ||
[[Category: Tettamanzi | [[Category: Myszka DG]] | ||
[[Category: Tettamanzi MC]] | |||
Latest revision as of 06:32, 27 November 2024
A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor
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