3j9b: Difference between revisions
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The | ==Electron cryo-microscopy of an RNA polymerase== | ||
<SX load='3j9b' size='340' side='right' viewer='molstar' caption='[[3j9b]], [[Resolution|resolution]] 4.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3j9b]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/goose/Guangdong/1/1996(H5N1)) Influenza A virus (A/goose/Guangdong/1/1996(H5N1))], [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/goose/Guangdong/3/1997(H5N1)) Influenza A virus (A/goose/Guangdong/3/1997(H5N1))] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J9B FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j9b OCA], [https://pdbe.org/3j9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j9b RCSB], [https://www.ebi.ac.uk/pdbsum/3j9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j9b ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q91R78_9INFA Q91R78_9INFA] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063] | |||
==See Also== | |||
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | |||
__TOC__ | |||
</SX> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Boruah BM]] | |||
[[Category: Chang SH]] | |||
[[Category: Feng F]] | |||
[[Category: Guan CC]] | |||
[[Category: Guo L]] | |||
[[Category: Li J]] | |||
[[Category: Liang HH]] | |||
[[Category: Liu YF]] | |||
[[Category: Sun DP]] | |||
[[Category: Wang HW]] | |||
[[Category: Wang J]] | |||
[[Category: Wang JW]] | |||
[[Category: Wang MT]] | |||
[[Category: Wang XL]] | |||
[[Category: Wojdyla J]] | |||
[[Category: Yang MR]] | |||
[[Category: Yuan LM]] | |||
Latest revision as of 08:41, 7 February 2024
Electron cryo-microscopy of an RNA polymerase
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