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[[Image:1yz4.jpg|left|200px]]


{{Structure
==Crystal structure of DUSP15==
|PDB= 1yz4 |SIZE=350|CAPTION= <scene name='initialview01'>1yz4</scene>, resolution 2.4&Aring;
<StructureSection load='1yz4' size='340' side='right'caption='[[1yz4]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
<table><tr><td colspan='2'>[[1yz4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YZ4 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yz4 OCA], [https://pdbe.org/1yz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yz4 RCSB], [https://www.ebi.ac.uk/pdbsum/1yz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yz4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DUS15_HUMAN DUS15_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yz/1yz4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yz4 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of DUSP15'''
==See Also==
 
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
 
*[[MAP kinase phosphatase|MAP kinase phosphatase]]
==About this Structure==
__TOC__
1YZ4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YZ4 OCA].
</StructureSection>
 
==Reference==
Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase., Yoon TS, Jeong DG, Kim JH, Cho YH, Son JH, Lee JW, Ryu SE, Kim SJ, Proteins. 2005 Nov 15;61(3):694-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16170801 16170801]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Cho YH]]
[[Category: Cho, Y H.]]
[[Category: Jeong DG]]
[[Category: Jeong, D G.]]
[[Category: Jeong SK]]
[[Category: Jeong, S K.]]
[[Category: Kim JH]]
[[Category: Kim, J H.]]
[[Category: Kim SJ]]
[[Category: Kim, S J.]]
[[Category: Lee JW]]
[[Category: Lee, J W.]]
[[Category: Ryu SE]]
[[Category: Ryu, S E.]]
[[Category: Son JH]]
[[Category: Son, J H.]]
[[Category: Yoon TS]]
[[Category: Yoon, T S.]]
[[Category: BOG]]
[[Category: SO4]]
[[Category: hydrolase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:29:19 2008''

Latest revision as of 08:07, 15 May 2024

Crystal structure of DUSP15

1yz4, resolution 2.40Å

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