3o5z: Difference between revisions
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==Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)== | ==Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)== | ||
<StructureSection load='3o5z' size='340' side='right' caption='[[3o5z]], [[Resolution|resolution]] 2.01Å' scene=''> | <StructureSection load='3o5z' size='340' side='right'caption='[[3o5z]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3o5z]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3o5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O5Z FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o5z OCA], [https://pdbe.org/3o5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o5z RCSB], [https://www.ebi.ac.uk/pdbsum/3o5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o5z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3o5z" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Phosphoinositide 3- | *[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Chen | [[Category: Large Structures]] | ||
[[Category: Hilgenfeld | [[Category: Chen S]] | ||
[[Category: Lei | [[Category: Hilgenfeld R]] | ||
[[Category: Ponnusamy | [[Category: Lei J]] | ||
[[Category: Tan | [[Category: Ponnusamy R]] | ||
[[Category: Xiao | [[Category: Tan J]] | ||
[[Category: Xiao Y]] | |||
Latest revision as of 09:29, 30 October 2024
Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)
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