4xuu: Difference between revisions
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New page: '''Unreleased structure''' The entry 4xuu is ON HOLD Authors: Hsu, F, Mao, Y Description: The hSac2 domain from human phosphoinositide phosphatase Sac2 [[Category: Unreleased Structure... |
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The | ==The hSac2 domain from human phosphoinositide phosphatase Sac2== | ||
<StructureSection load='4xuu' size='340' side='right'caption='[[4xuu]], [[Resolution|resolution]] 2.62Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XUU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.62Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuu OCA], [https://pdbe.org/4xuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xuu RCSB], [https://www.ebi.ac.uk/pdbsum/4xuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xuu ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SAC2_HUMAN SAC2_HUMAN] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.<ref>PMID:11274189</ref> <ref>PMID:17322895</ref> | |||
==See Also== | |||
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | |||
*[[Phosphoinositide phosphatase|Phosphoinositide phosphatase]] | |||
[[Category: | == References == | ||
[[Category: Hsu | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hsu F]] | |||
[[Category: Mao Y]] | |||
Latest revision as of 00:55, 28 December 2023
The hSac2 domain from human phosphoinositide phosphatase Sac2
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