6c0w: Difference between revisions
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==Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing CENP-A== | |||
<SX load='6c0w' size='340' side='right' viewer='molstar' caption='[[6c0w]], [[Resolution|resolution]] 4.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6c0w]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._'clone_D_i2' Escherichia coli str. 'clone D i2'] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C0W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c0w OCA], [https://pdbe.org/6c0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c0w RCSB], [https://www.ebi.ac.uk/pdbsum/6c0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c0w ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> | |||
==See Also== | |||
*[[Centromere protein 3D structure|Centromere protein 3D structure]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: | [[Category: Escherichia coli str. 'clone D i2']] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Luger K]] | ||
[[Category: | [[Category: Morgan GP]] | ||
[[Category: Musacchio A]] | |||
[[Category: Pentakota S]] | |||
[[Category: Petrovic A]] | |||
[[Category: Vetter IR]] | |||
[[Category: Zhou K]] | |||
Latest revision as of 14:25, 13 March 2024
Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing CENP-A
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