Negative elongation factor: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='6gml' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Negative elongation factor''' (NELF) induces RNA polymerase II pro... |
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<StructureSection load='5l3x' size='340' side='right' caption='Human NELF A (grey) complex with NELF C/D (green) and Cl- ion (green) (PDB code [[5l3x]])' scene=''> | |||
<StructureSection load=' | |||
== Function == | == Function == | ||
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NELF has been implicated in various diseases ranging from neurological disorders to cancer<ref>PMID:19245807</ref>. | NELF has been implicated in various diseases ranging from neurological disorders to cancer<ref>PMID:19245807</ref>. | ||
</StructureSection> | </StructureSection> | ||
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[[5l3x]] - hNELF A + NELF C/D - human<br /> | [[5l3x]] - hNELF A + NELF C/D - human<br /> | ||
[[2bz2]], [[1x5p]], [[2jx2]] - hNELF E RNA recognition motif - NMR<br /> | [[2bz2]], [[1x5p]], [[2jx2]] - hNELF E RNA recognition motif - NMR<br /> | ||
[[6gml]] - | [[8jj6]] - hNELF B + NELF C/D <br /> | ||
[[6gml]], [[8uha]], [[8uhd]], [[8uhg]], [[8ui0]], [[8uis]], [[8w8e]] - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA - Cryo EM<br /> | |||
[[7ycx]] - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + RPB12 + DNA + RNA - Cryo EM<br /> | |||
[[9j0n]], [[9j0p]], [[9j0o]] - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + nucleosome + DNA + RNA - Cryo EM<br /> | |||
[[9vd9]] - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + DNA + RNA - Cryo EM<br /> | |||
[[7pks]] - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + serine/threonine-protein phosphatase + DNA + RNA - Cryo EM<br /> | |||
[[8rbx]] - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + nucleosome + serine/threonine-protein phosphatase + DNA + RNA - Cryo EM | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 09:02, 24 March 2026
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3D structures of negative elongation factor
Updated on 24-March-2026
5l3x - hNELF A + NELF C/D - human
2bz2, 1x5p, 2jx2 - hNELF E RNA recognition motif - NMR
8jj6 - hNELF B + NELF C/D
6gml, 8uha, 8uhd, 8uhg, 8ui0, 8uis, 8w8e - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + DNA + RNA - Cryo EM
7ycx - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + RPB12 + DNA + RNA - Cryo EM
9j0n, 9j0p, 9j0o - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + nucleosome + DNA + RNA - Cryo EM
9vd9 - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + DNA + RNA - Cryo EM
7pks - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + serine/threonine-protein phosphatase + DNA + RNA - Cryo EM
8rbx - hNELF A + hNELF B + hNELF C/D + hNELF E + DNA-directed RNA polymerase II + transcription elongation factors SPT4-SPT5 + integrator complex + nucleosome + serine/threonine-protein phosphatase + DNA + RNA - Cryo EM
