Hydroxylases 3D structures: Difference between revisions

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**[[2v27]], [[2v28]] – PAH – ''Colwellia psychrerythraea''<br />
**[[2v27]], [[2v28]] – PAH – ''Colwellia psychrerythraea''<br />
**[[1ltu]], [[1ltv]] – CvPAH – ''Chromobacterium violaceum''<br />
**[[1ltu]], [[1ltv]] – CvPAH – ''Chromobacterium violaceum''<br />
**[[4bpt]] – PAH –'' Legionella pneumophila''<br />
**[[4bpt]] – PAH – ''Legionella pneumophila''<br />
**[[1ltz]] - CvPAH + cofactor<br />
**[[1ltz]] - CvPAH + cofactor<br />
**[[3tcy]], [[3tk2]] – CvPAH + phenylalanine<br />
**[[3tcy]], [[3tk2]] – CvPAH + phenylalanine<br />
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**[[4jpx]] - CvPAH (mutant) + Co + phenylalanine<br />
**[[4jpx]] - CvPAH (mutant) + Co + phenylalanine<br />
**[[4jpy]] - CvPAH + Fe + phenylalanine<br />
**[[4jpy]] - CvPAH + Fe + phenylalanine<br />
**[[7vgm]] - PAH + Fe – Bacillus cereus<br />
**[[7vgm]] - PAH + Fe – ''Bacillus cereus''<br />


*Tyrosine hydroxylase (cofactor tetrahydrobiopterin)
*Tyrosine hydroxylase (cofactor tetrahydrobiopterin)
Line 42: Line 42:
**[2toh]], [[1toh]] – rTH catalytic and tetramerization domains 160-498 – rat
**[2toh]], [[1toh]] – rTH catalytic and tetramerization domains 160-498 – rat
**[[2mda]] – rTH regulatory domain 65-159 – NMR<br />
**[[2mda]] – rTH regulatory domain 65-159 – NMR<br />
**[[7kqr]], [[7kqs]], [[7kqt]], [[7kqu]] – TH + heme + Tyr derivative – Streptomyces sclerotialus <br />
**[[8r2s]] – SsTH (mutant) + heme – ''Streptomyces sclerotialus'' <br />
**[[7kqr]], [[7kqs]], [[7kqt]], [[7kqu]], [[8vmk]] – SsTH + heme + Tyr derivative <br />


*Tryptophan hydroxylase
*Tryptophan hydroxylase


**[[7wiy]] – hTPH 2 + Fe – Cryo EM<br />
**[[7wiy]] – hTPH 2 + Fe – Cryo EM<br />
**[[3hf8]], [[3hfb]], [[3hf6]], [[5tpg]], [[5l01]], [[5j6d]], [[7zig]], [[7zih]], [[7zif]], [[7zii]], [[7zij]], [[7zik]] – hTPH 1 catalytic domain 105-401 + inhibitor + Fe <br />
**[[3hf8]], [[3hfb]], [[3hf6]], [[5tpg]], [[5l01]], [[5j6d]], [[7zig]], [[7zih]], [[7zif]], [[7zii]], [[7zij]], [[9he3]], [[8cji]], [[8cjj]], [[8cjk]], [[8cjl]], [[8cjm]], [[8cjn]], [[8cjo]] – hTPH 1 catalytic domain 105-401 + inhibitor + Fe <br />
**[[1mlw]] – hTPH catalytic domain+ biopterin + Fe<br />
**[[1mlw]] – hTPH catalytic domain+ biopterin + Fe<br />
**[[4v06]] - hTPH 2 catalytic domain + Fe<br />
**[[4v06]] - hTPH 2 catalytic domain + Fe<br />
**[[8hb7]], [[9hb8]] - hTPH 2 catalytic domain + Fe + inhibitor<br />
**[[7qri]] - hTPH 2 regulatory domain 48-145 + Phe - NMR<br />
**[[7qri]] - hTPH 2 regulatory domain 48-145 + Phe - NMR<br />
**[[3e2t]] – TPH 1 catalytic domain + Trp + Fe – chicken
**[[3e2t]] – TPH 1 catalytic domain + Trp + Fe – chicken
Line 67: Line 69:
**[[1dod]], [[1doe]], [[1iuv]], [[1iuw]], [[1iux]] – PaPHBH + FAD + DHB derivative<br />
**[[1dod]], [[1doe]], [[1iuv]], [[1iuw]], [[1iux]] – PaPHBH + FAD + DHB derivative<br />
**[[1ius]], [[1iut]], [[1iuu]] – PaPHBH + FAD + 4-aminobenzoate <br />
**[[1ius]], [[1iut]], [[1iuu]] – PaPHBH + FAD + 4-aminobenzoate <br />
**[[8y2s]] – PaPHBH + FAD + hydroxy-methylbenzoate <br />
**[[6ju1]] – PaPHBH (mutant) + FAD  + DHB derivative <br />
**[[6ju1]] – PaPHBH (mutant) + FAD  + DHB derivative <br />
**[[1d7l]] – PaPHBH + FAD derivative + PHB <br />
**[[1d7l]] – PaPHBH + FAD derivative + PHB <br />
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**[[1k0j]] – PaPHBH (mutant) + FAD + NADPH <br />
**[[1k0j]] – PaPHBH (mutant) + FAD + NADPH <br />
**[[1k0l]] – PaPHBH (mutant) + FAD  <br />
**[[1k0l]] – PaPHBH (mutant) + FAD  <br />
**[[5tti]], [[6dll]] – PfPHBH + FAD – ''Pseudomonas putida''<br />
**[[6dll]] – PfPHBH + FAD – ''Pseudomonas putida''<br />
**[[2dki]] – CtPHBH + FAD – Comamonas testosteroni<br />
**[[2dki]] – CtPHBH + FAD – ''Comamonas testosteroni''<br />
**[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br />
**[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br />
**[[8r2t]] – PHBH + FAD – ''Gelatoporia subvermipora''<br />


*Apartyl/asparaginyl  b-hydroxylase; Domain – oxygenase and TPR 301-758
*Apartyl/asparaginyl  b-hydroxylase; Domain – oxygenase and TPR 301-758
Line 83: Line 87:
**[[5jza]] – hAAH oxygenase and TPR domain + oxalylglycine + Mn <br />
**[[5jza]] – hAAH oxygenase and TPR domain + oxalylglycine + Mn <br />
**[[6yyu]], [[6yyv]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn <br />
**[[6yyu]], [[6yyv]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn <br />
**[[6yyw]], [[6yyx]], [[6yyy]], [[6z6q]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide<br />
**[[6yyw]], [[6yyx]], [[6yyy]], [[6z6q]], [[8re8]], [[8re9]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide<br />
**[[5jz8]], [[5jzu]], [[5jzz]], [[5jqy]], [[6rk9]], [[6z6r]] – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide<br />
**[[8re6]], [[8re7]] – hAAH oxygenase and TPR domain (mutant) + oxoglutarate + Mn + coagulation factor X peptide<br />
**[[5jqy]], [[5jz8]], [[5jzu]], [[6rk9]], [[6z6r]], [[8re5]] – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide<br />
**[[7e6j]] – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide<br />
**[[7e6j]] – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide<br />
**[[6q9f]], [[6q9i]] – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide<br />
**[[6q9f]], [[6q9i]] – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide<br />
Line 91: Line 96:
*Alpha-ketoglutarate-dependent L-arginine hydroxylase
*Alpha-ketoglutarate-dependent L-arginine hydroxylase


**[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – Streptomyces vinaceus<br />
**[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – ''Streptomyces vinaceus''<br />
**[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br />
**[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br />
**[[9eqf]] – AAH + arginine + succinate + Fe - synthetic<br />
**[[6y0n]] – SvAAH + arginine + AKG + Fe <br />
**[[6y0n]] – SvAAH + arginine + AKG + Fe <br />
**[[6db2]], [[6alr]] – SvAAH + homoarginine + succinate + V <br />
**[[6db2]], [[6alr]] – SvAAH + homoarginine + succinate + V <br />
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*PLP-dependent L-arginine hydroxylase
*PLP-dependent L-arginine hydroxylase


**[[6c9b]] – SwAAH + PLP – Streptomyces wadayamensis<br />
**[[6c9b]] – SwAAH + PLP – ''Streptomyces wadayamensis''<br />
**[[5dj1]] – SwAAH + PLP + Mg<br />
**[[5dj1]] – SwAAH + PLP + Mg<br />
**[[5dj3]] – SwAAH + PLP-arginine + Mg<br />
**[[5dj3]] – SwAAH + PLP-arginine + Mg<br />
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*Leucine hydroxylase
*Leucine hydroxylase


**[[5nch]] – StAAH – Streptomyces <br />
**[[5nch]] – StAAH – ''Streptomyces'' <br />
**[[5nci]] – StAAH + leucine derivative + oxoglutarate + Co <br />
**[[5nci]] – StAAH + leucine derivative + oxoglutarate + Co <br />
**[[5ncj]] – StAAH + leucine derivative + succinate + Mn <br />
**[[5ncj]] – StAAH + leucine derivative + succinate + Mn <br />
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*L-arginine b-hydroxylase or non-heme iron oxygenase
*L-arginine b-hydroxylase or non-heme iron oxygenase


**[[4m23]] – SlORFP – Streptomyces lavendulae<br />
**[[4m23]] – SlORFP – ''Streptomyces lavendulae''<br />
**[[4m2i]] – SlORFP + Fe <br />
**[[4m2i]] – SlORFP + Fe <br />
**[[4m25]] – SlORFP + Fe + ketoglutarate <br />
**[[4m25]] – SlORFP + Fe + ketoglutarate <br />
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**[[4m2f]] – SlORFP + Fe + canavanine<br />
**[[4m2f]] – SlORFP + Fe + canavanine<br />
**[[4m2g]], [[4m26]] – SlORFP + Fe + succinate + Arg derivative<br />
**[[4m2g]], [[4m26]] – SlORFP + Fe + succinate + Arg derivative<br />
**[[2wbo]] – SvVIOC + Fe + Arg – Streptomyces vinaceus<br />
**[[2wbo]] – SvVIOC + Fe + Arg – ''Streptomyces vinaceus''<br />
**[[2wbq]] – SvVIOC + Arg derivative<br />
**[[2wbq]] – SvVIOC + Arg derivative<br />
**[[2wbp]] – SvVIOC + Fe + succinate + Arg derivative<br />
**[[2wbp]] – SvVIOC + Fe + succinate + Arg derivative<br />
**[[6daw]] – NAPI + Fe + Arg – Streptomyces lusitanus<br />
**[[6daw]] – NAPI + Fe + Arg – ''Streptomyces lusitanus''<br />
 
*Prolyl  3-hydroxylase
 
**[[8k0e]] - hPH 1 + cartilage-associated protein – Cryo EM<br />
**[[8k0f]], [[8k0i]], [[8k0m]] - hPH 1 + cartilage-associated protein + PPIASE – Cryo EM<br />
**[[8k17]] - hPH 1 + cartilage-associated protein + PPIASE + peptide – Cryo EM<br />


*Prolyl  4-hydroxylase
*Prolyl  4-hydroxylase
Line 132: Line 144:
**[[6evl]] - hPH a2 subunit <br />
**[[6evl]] - hPH a2 subunit <br />
**[[6evm]], [[6evn]], [[6evo]], [[6evp]] - hPH a2 subunit + peptide<br />
**[[6evm]], [[6evn]], [[6evo]], [[6evp]] - hPH a2 subunit + peptide<br />
**[[3itq]], [[5hv0]] - BaPH – Bacillus anthracis <br />
**[[3itq]], [[5hv0]] - BaPH – ''Bacillus anthracis'' <br />
**[[5hv4]] - BaPH + ketoglutarate<br />
**[[5hv4]] - BaPH + ketoglutarate<br />
**[[5c5u]] - PcvPH + Mn – Paramecium chlorella virus <br />
**[[5c5u]] - PcvPH + Mn – Paramecium chlorella virus <br />
**[[5c5t]] - PcvPH + Mn + Zn <br />
**[[5c5t]] - PcvPH + Mn + Zn <br />
**[[4p7x]] - RlPH + Co + pipecolic acid – Rhizobium loti <br />
**[[4p7x]] - RlPH + Co + pipecolic acid – ''Rhizobium loti'' <br />
**[[4p7w]] - RlPH + Co + proline<br />
**[[4p7w]] - RlPH + Co + proline<br />
**[[6iuq]] - PH + Fe – Phytophthora capsici<br />
**[[6iuq]] - PH + Fe – ''Phytophthora capsici''<br />
**[[2v4a]], [[2jij]] - CrPH – Chlamydomonas reinhardtii <br />
**[[2v4a]], [[2jij]] - CrPH – ''Chlamydomonas reinhardtii'' <br />
**[[2jig]] - CrPH + Zn + pyridine derivative<br />
**[[2jig]] - CrPH + Zn + pyridine derivative<br />
**[[3gze]] - CrPH + Zn + peptide<br />
**[[3gze]] - CrPH + Zn + peptide<br />
Line 147: Line 159:
*Lysine  4-hydroxylase
*Lysine  4-hydroxylase


**[[6f9p]] – FlL4H + Fe – Flavobacterium <br />
**[[6f9p]] – FlL4H + Fe – ''Flavobacterium'' <br />
**[[6exf]] – FlL4H + Fe + lysine <br />
**[[6exf]] – FlL4H + Fe + lysine <br />
**[[6euo]] – FlL4H + Fe + succinate derivative<br />
**[[6euo]] – FlL4H + Fe + succinate derivative<br />
Line 155: Line 167:
*Lysine  3-hydroxylase
*Lysine  3-hydroxylase


**[[6f2e]] – CaL3H – Catenulispora acidiphila <br />
**[[6f2e]] – CaL3H – ''Catenulispora acidiphila'' <br />
**[[6f2b]] – CaL3H + Fe + oxoglutarate  <br />
**[[6f2b]] – CaL3H + Fe + oxoglutarate  <br />
**[[6f2a]] – CaL3H + Fe + lysine  <br />
**[[6f2a]] – CaL3H + Fe + lysine  <br />
Line 164: Line 176:
**[[6bz5]] - PpSH <br />
**[[6bz5]] - PpSH <br />
**[[5evy]] - PpSH + FAD + salicilate <br />
**[[5evy]] - PpSH + FAD + salicilate <br />
**[[7c8z]] - SH + Fe2S2 + Fe - Ralstonia <br />
**[[7c8z]] - SH + Fe2S2 + Fe - ''Ralstonia'' <br />


*Dopamine b-hydroxylase (cofactor ascorbic acid)
*Dopamine b-hydroxylase (cofactor ascorbic acid)
Line 172: Line 184:
*Ectoine hydroxylase
*Ectoine hydroxylase


**[[4mhr]] - SaEH – Sphingopyxis alaskensis <br />
**[[4mhr]] - SaEH – ''Sphingopyxis alaskensis'' <br />
**[[4mhu]] - SaEH + Fe  <br />
**[[4mhu]] - SaEH + Fe  <br />
**[[4q5o]] - SaEH + Fe + 5-hydroxyectoine <br />
**[[4q5o]] - SaEH + Fe + 5-hydroxyectoine <br />
**[[4nmi]] - VsEH – Virgibacillus salexigens<br />
**[[4nmi]] - VsEH – ''Virgibacillus salexigens''<br />
**[[3emr]] - VsEH + Fe  <br />
**[[3emr]] - VsEH + Fe  <br />


Line 182: Line 194:
**[[6ttm]], [[6ttn]] - dHH + Ni + oxalylglycine + hyoscyamine – datura<br />
**[[6ttm]], [[6ttn]] - dHH + Ni + oxalylglycine + hyoscyamine – datura<br />
**[[6tto]] - dHH + Ni + oxoglutaratee <br />
**[[6tto]] - dHH + Ni + oxoglutaratee <br />
**[[8cv8]], [[8cvb]] - dHH + Fe + oxoglutarate + hyoscyamine <br />
**[[8cve]], [[8cvg]] - dHH (mutant) + Fe + oxoglutarate + hyoscyamine <br />
**[[8cva]] - dHH + Fe + succinate + hyoscyamine <br />
**[[8cv9]], [[8cvc]] - dHH + V + succinate + hyoscyamine <br />
**[[8cvf]], [[8cvh]] - dHH (mutant) + V + succinate + hyoscyamine <br />
**[[8cvd]] - dHH + Fe + succinate + scopolamine <br />


*Cytochrome P450  hydroxylase See [[Cytochrome P450 hydroxylase]]
*Cytochrome P450  hydroxylase See [[Cytochrome P450 hydroxylase]]

Latest revision as of 08:10, 24 September 2025

3D structures of hydroxylases

Updated on 24-September-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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