Severin: Difference between revisions
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'''3D Structure of Severin''' <br /> | '''3D Structure of Severin''' <br /> | ||
The image at the top is a human Severin | The image at the top is a human Severin ([[3fg6]]) | ||
== Actin Binding Protein == | == Actin Binding Protein == | ||
Revision as of 11:45, 22 July 2010
3D Structure of Severin
The image at the top is a human Severin (3fg6)
Actin Binding Protein
Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from Gelsolin (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is a octamer (each monomer is colored in different colors) of the Severin with calcium ions (colored lime).
3D Structures of Severin
3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR
