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| {{#tree:id=OrganizedByTopic|openlevels=0| | | {{#tree:id=OrganizedByTopic|openlevels=0| |
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| * Talin subdomains | | * Talin mouse subdomains: F0 1-85; F2 86-202; F3 203-405; VBS1 482-655; R4 913-1044; B 1046-1207; C 1207-1357; R7-R8 1359-1659; rod 1359-2293; dimerization 2494-2541 |
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| **[[2x0c]] – mTal rod residues 1359-1659 – mouse<br /> | | **[[2kc1]], [[6ba6]] - mTal F0 domain – mouse - NMR<br /> |
| **[[5ic0]], [[2kbb]] – mTal residues 1357-1822<br /> | | **[[2kc2]] - mTal F2 domain – NMR<br /> |
| **[[5ic1]] – mTal residues 1357-1822 (mutant)<br /> | | **[[2kma]] – mTal F1F2 domain – NMR<br /> |
| **[[3dyj]] - mTal residues 1974-2293<br /> | | **[[3ivf]] – mTal FERM domain F1F2F3 <br /> |
| **[[1sj7]], [[1sj8]] - mTal residues 482-655<br /> | | **[[4f7g]] - mTal F2F3 domain + rod segment domain residues 1654-1847<br /> |
| **[[2kma]] – mTal F1F2 residues 1-202 – NMR<br /> | | **[[2kgx]] – mTal F3 domain + rod fragment residues 1655-1822 – NMR<br /> |
| **[[2kc1]] - mTal F1 residues 1-85 – NMR<br /> | | **[[1sj7]], [[1sj8]] - mTal VBS1 domain<br /> |
| **[[2kc2]] - mTal F2 residues 86-202 – NMR<br /> | | **[[5nl1]] - mTal VBS1 domain + IPAA<br /> |
| **[[3ivf]] – mTal FERM domain F1F2F3 residues 1-400<br /> | | **[[2lqg]] - mTal R4 helix domain – NMR<br /> |
| **[[2qdq]] – mTal dimerization domain residues 2494-2541<br /> | | **[[2l7n]] – mTal B domain – NMR<br /> |
| | **[[2l10]] – mTal C domain – NMR<br /> |
| | **[[2x0c]] – mTal rod residues 1359-1659 <br /> |
| | **[[5ic0]], [[2kbb]] – mTal triple domain residues 1357-1822<br /> |
| | **[[5ic1]] – mTal triple domain residues 1357-1822 (mutant)<br /> |
| | **[[4w8p]] - mTal R7-8 + RIAM <br /> |
| | **[[5fzt]] - mTal R7-8 + Rho GTPase activating protein 7 peptide <br /> |
| | **[[3dyj]] - mTal rod residues 1974-2293<br /> |
| | **[[2qdq]] – mTal dimerization domain<br /> |
| | **[[2mwn]] – hTal1 residues 308-400 + RIAM – human - NMR<br /> |
| **[[2hrj]] - cTal F2 – chicken - NMR <br /> | | **[[2hrj]] - cTal F2 – chicken - NMR <br /> |
| **[[1mix]] – cTal F2F3 residues 196-400<br /> | | **[[1mix]] – cTal F2F3 residues 196-400<br /> |
| **[[4f7g]] - mTal F2F3 residues 206-405 + rod segment domain residues 1654-1847<br />
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| **[[2kgx]]– mTal F3 residues 334-402 +mTal fragment residues 1655-1822– NMR<br />
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| **[[2l10]] – mTal residues 1206-1357 – NMR<br />
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| **[[2l7n]] – mTal residues 1046-1207 – NMR<br />
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| **[[2lqg]] - mTal R4 helix residues 913-1044 – NMR<br />
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| **[[4w8p]] - mTal R7-8 residues 1359-1659 + RIAM <br />
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| **[[5fzt]] - mTal R7-8 residues 1359-1659 + Rho GTPase activating protein 7 peptide <br />
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| **[[2mwn]] – hTal1 residues 308-400 + RIAM – human - NMR<br />
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| * Talin integrin-binding sites | | * Talin integrin-binding sites |
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Talin is involved in cell-cell contacts. It links integrins to actin[1]. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.
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3D Structures of Talin
Updated on 24-September-2018
{"openlevels":0}
- Talin mouse subdomains: F0 1-85; F2 86-202; F3 203-405; VBS1 482-655; R4 913-1044; B 1046-1207; C 1207-1357; R7-R8 1359-1659; rod 1359-2293; dimerization 2494-2541
- Vinculin, 6ba6 - mTal F0 domain – mouse - NMR
- 2kc2 - mTal F2 domain – NMR
- 2kma – mTal F1F2 domain – NMR
- 3ivf – mTal FERM domain F1F2F3
- 4f7g - mTal F2F3 domain + rod segment domain residues 1654-1847
- 2kgx – mTal F3 domain + rod fragment residues 1655-1822 – NMR
- 1sj7, 1sj8 - mTal VBS1 domain
- 5nl1 - mTal VBS1 domain + IPAA
- 2lqg - mTal R4 helix domain – NMR
- 2l7n – mTal B domain – NMR
- 2l10 – mTal C domain – NMR
- 2x0c – mTal rod residues 1359-1659
- 5ic0, 2kbb – mTal triple domain residues 1357-1822
- 5ic1 – mTal triple domain residues 1357-1822 (mutant)
- 4w8p - mTal R7-8 + RIAM
- 5fzt - mTal R7-8 + Rho GTPase activating protein 7 peptide
- 3dyj - mTal rod residues 1974-2293
- 2qdq – mTal dimerization domain
- 2mwn – hTal1 residues 308-400 + RIAM – human - NMR
- 2hrj - cTal F2 – chicken - NMR
- 1mix – cTal F2F3 residues 196-400
- Talin integrin-binding sites
- 2jsw, 2qdq – mTal IBS – NMR
- 3g9w – mTal2 F2F3+integrin tail
- 1miz, 1mk7, 1mk9 - cTal F2F3 residues 200-400 +integrin tail
- 2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
- 3fyq – Tal rod IBS2 residues 1981-2168 – Drosophila melanogaster
- Talin vinculin-binding sites
- 2kvp, 2b0h – mTal VBS3 residues 2300-2482 – NMR
- 1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
- 1u6h - cTal VBS2 residues 849-879 + vinculin head
- 1t01 - meal VBS1 residues 605-628 + vinculin head
- 1syq - hTal VBS1+ vinculin head
- 1rkc - cTal VBS3+ vinculin head
- 3s90 - mTal VBS3 residues 1512-1546 + vinculin head
- 1u89, 2l7a - mTal VBS2 – NMR
- 4dj9 – hTal VBS50 + vinculin head
- Talin phosphatidylinositol phosphate kinase binding sites
- 1y19 - mTal F2F3+ PIP kinase C-terminal
- 2g35 - mTal F3+PIP kinase peptide – NMR
- Talin layilin-binding sites
- 2k00 - cTal F3+layilin fragment – NMR
References