Colony-stimulating factor

spinqualitylabelsall models Glycosylated human macrophage colony-stimulating factor (green and yellow) complex with macrophage colony-stimulating factor 1 receptor (grey and pink) (PDB code 4wrl) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Colony-stimulating factors (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells. Four distinct CSFs were characterized. Granulocyte colony-stimulating factor (G-CSF) acts on proliferation, functional stimulation and differentiation of progenitors of neutrophils. Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes. Macrophage colony-stimulating factor (M-CSF) or lanimostin acts on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages. multi-colony-stimulating factor also known as interleukin 3. Relevance Depletion of CSFs have therapeutic benefit in many inflammatory and autoimmune conditions. G-CSF and GM-CSF are used to increase low white blood cell levels in cancer patients following chemotherapy and to release haematopoietic stem cells which replace bone marrow cells after anti-cancer treatments. G-CSF is a neurotrophic factor and thus a candidate for the treatment of neurodegenerative conditions. G-CSF and GN-CSF ar commercially available for clinical use.

3D structures of colony-stimulating factor

Updated on 14-November-2018

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• Macrophage colony stimulating factor
  • 2gmf, 3uf2 - hM-CSF - human
    
  • 5lxf - hM-CSF (mutant)
    
  • 4adq, 4adf - hM-CSF + BARF1
    
  • 3uez - hM-CSF (mutant) + BARF1
    
  • 4wrm, 4wrl - hG-CSF + CSF receptor
    
  • 3uf5 - mM-CSF - mouse
    
  • 3ejj - mM-CSF + CSF receptor
    
• Granulocyte-macrophage colony stimulating factor
  • 2gmf, 1csg - hGM-CSF
    
  • 5c7x, 5d70, 5d71, 5d72, 6bfq, 6bfs - hGM-CSF + antibody
    
  • 4rs1 - hGM-CSF + CSF receptor
    
  • 4nkq - hGM-CSF + CSF receptor + cytokine receptor
    
  • 5d22 - sGM-CSF - sheep
    
  • 5d28 - sGM-CSF + CSF inhibition factor
    
• Granulocyte colony stimulating factor
  • 1bgc - G-CSF - bovine
    
  • 1bgd, 1bge - G-CSF - dog
    
  • 1rhg - hG-CSF
    
  • 1gnc - hG-CSF - NMR
    
  • 5gw9 - hG-CSF (mutant)
    
  • 2d9q, 1pgr, 1cd9 - hG-CSF + CSF receptor
    
  • 1gcf, 1cto - mG-CSF C-terminal of LBD - NMR
    

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Michal Harel, Alexander Berchansky