Mevalonate kinase

spinqualitylabelsall models Mevalonate kinase complex with mevalonate (PDB code 2hfu). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Mevalonate kinase (MK) is the first enzyme in the mevalonate pathway which synthesizes sterol isoprenoids like cholesterol and non-sterol isoprenoids like ubiquinone. MK catalyzes the conversion of mevalonate to 5-phosphomevalonate. Disease Mutations in MK resulting in MK deficiency cause hyperimmunoglobulinenemia D, a type of severe early-onset colitis, characterized by abdominal pain, diarrhea and vomiting. Structural highlights The 3D structure of MK complex with mevalonate shows the enzyme composed of 2 domains: The N-terminal and the C-terminal. The mevalonate binds in a deep cleft between the 2 domains forming H-bond interactions with Arg and Tyr residues and several hydrophobic interactions. 3D structures of mevalonate kinase 2r3v - hMK - human 2r42 - rMK + farnesyl thiopyrophosphate- rat 1kvk - rMK + ATP 4hac - MmMK - Methanosarcina mazei 6mde - MmMK + mevalonate 6mdf - MmMK + 5-phosphomevalonate 1kkh, 1vis - MK - Methancaldococcus jannaschii 2oi2 - MK + diphosphomevalonate - Streptococcus pneumaniae 2hfs - LmMK - Leishmania major 2hfu - LmMK + mevalonate 2x7i - LmMK - Staphylococcus aureus

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