MHC 3D structures

3D structures of MHC

Updated on 25-June-2023 {{#tree:id=OrganizedByTopic|openlevels=0|

• MHC I

• MHC I binary complex

• • 1hla, 2hla, 3hla, 6tdr, 6tds - hMHC I + -2-microglobulin – human
    
  • 1zs8 - mMHC I + -2-microglobulin – mouse
    
  • 6mp0, 6mp1 - mMHC I + peptide
    
  • 3p73, 3p77 - cMHC I + -2-microglobulin – chicken
    

• Human MHC I ternary complex

• • 3kpn, 3kpo – hMHC I B + -2-microglobulin + peptide
    
  • 1a1m, 1a1n, 1a1o, 1a9b, 1a9e, 1b0g, 1e27, 1e28, 1hhg, 1hhh, 1hhi, 1hhj, 1hhk, 1hsa, 1hsb, 1jf1, 1jge, 1jht, 1i4f, 1k5n, 1kpr, 1k5n, 1i1y, 1i1f, 1i7r, 1i7t, 1i7u, 1mhe, 1n2r, 1ogt, 1q94, 1qew, 1qqd, 1qvo, 1s7q, 1s8d, 1s9w, 1s9x, 1s9y, 1t1w, 1t1x, 1t1y, 1t1z, 1t20, 1t21, 1t22, 1tmc, 1tvb, 1tvh, 1uxs, 1uxw, 1w0v, 1w0w, 1xh3, 1xr8, 1xr9, 1ydp, 1zhk, 1zhl, 1zsd, 2a83, 2axf, 2axg, 2bck, 2bsr, 2bss, 2bst, 2bvo, 2bvp, 2bvq, 2c7u, 2cik, 2clr, 2d31, 2fyy, 2fz3, 2git, 2gt9, 2gtw, 2gtz, 2guo, 2h6p, 2hjk, 2hjl, 2hn7, 2nw3, 2rfx, 2v2w, 2v2x, 2vab, 2x4n, 2x4o, 2x4p, 2x4q, 2x4r, 2x4s, 2x4t, 2x4u, 2x70, 2xpg, 3am8, 3bev, 3b3i, 3b6s, 3bgm, 3bh8, 3bh9, 3bhb, 3bo8, 3bp4, 3bp7, 3bvn, 3bw9, 3bwa, 3bze, 3bzf, 3c9n, 3czf, 3d18, 3d25, 3dtx, 3dx6, 3dx8, 3dxa, 3fqn, 3fqr, 3fqt, 3fqu, 3fqw, 3fqx, 3giv,3h7b, 3hcv, 3hpj, 3kpl, 3kpm, 3kpn, 3kpo, 3kpp, 3kpq, 3kpr, 3kps, 3l3d, 3l3g, 3l3i, 3l3j, 3l3k, 3i6g, 3i6k, 3i6l, 3lka, 3lkn, 3lko, 3lkp, 3lkq, 3lkr, 3lks, 3ln4, 3ln5, 3lv3, 3mgo, 3mgt, 3mr9, 3mrb, 3mrc, 3mrd, 3v5h, 3v5k, 3vfr, 3vfs, 3vfv, 3vxn, 3vxo, 3wlb, 4jqx, 4k7f, 4l29, 4lnr, 4mj6, 4no5, 4nqx, 4prb, 4prd, 4pre, 4prn, 4qrq, 4qrs, 4qrt, 4u1i, 4wj5, 4wu5, 4wu7, 5c0d, 5c0f, 5c0j, 5d9s, 5eo0, 5eo1, 5eu4, 5hhn, 5ib3, 5meo, 5t6x, 5txs, 5v5l, 5vvp, 5vud, 5w67, 5wxc, 5wxd, 5xos, 6amt, 6at5, 6at9, 6bxp, 6bxq, 6d29, 6d2b, 6d2r, 6d2t, 6ei2, 6g3j, 6g3k, 6ggm, 6gh1, 6gh4, 6ghn, 6gl1, 6h6d, 6iex, 6j1v, 6j1w, 6joz, 6jp3, 6jtn, 6jto, 6jtp, 6l9n, 6mtl, 6nca, 6o4y, 6o4z, 6o51, 6o53, 6o9b, 6o9c, 6opd, 6p23, 6p27, 6p2c, 6p2f, 6p2s, 6pbh, 6ptb, 6pte, 6pyj, 6pyl, 6pyv, 6pyw, 6pz5, 6q3k, 6ss7, 6ss8, 6ss9, 6ssa, 6tdo, 6tdp, 6tdq, 6trn, 6uj8, 6ujo, 6ujq, 6uli, 6ulk, 6uzm, 6uzn, 6uzo, 6uzp, 6uzq, 6uzs, 6v2o, 6v2p, 6v2q, 6vb0, 6vb1, 6vb2, 6vb5, 6vb6, 6vb7, 6vb6, 6vb7, 6viu, 6vpz, 6vq2, 6vqd, 6vqe, 6vqy, 6vqz, 6vr1, 6vr5, 6xqa, 6y26, 6y27, 6y28, 6y29, 6y2a, 6y2b, 6z9v, 6z9w, 6z9x, 7alo, 7ciq, 7cir, 7cis, 7dyn, 7ejm, 7ji2, 7jyv, 7jyu, 7jyw, 7jyx, 7lgp, 7mj6, 7mj7, 7mj8, 7mj9, 7mja, 7nmd, 7nui, 7ow3, 7ow4, 7p49, 7p4b, 7q98, 7r7v, 7r7w, 7r7x, 7r7y, 7re8, 7rzd, 7rzj, 7s79, 7s7d, 7s7e, 7s7f, 7s8a, 7s8e, 7s8f, 7sif, 7sig, 7sih, 7t5m, 7tlt, 7u21, 7wj2, 7wj3, 7wt3, 7wt4 , 7wt5, 7wzz, 7x00, 7xf3, 7zuc- hMHC I + -2-microglobulin + peptide
    
  • 1cg9, 1kpr, 1ktl, 1m05, 1m6o, 2av1, 2av7, [[3ft2, 3ft3, 3ft4, 3gso, 3gsq, 3gsr, 3gsu, 3gsv, 3gsw, 3gsx, 3h9h, 3kww, 3kyo, 3ixa, 3vfm, 3vfo, 3x11, 3x12, 3x14, 6iwh, 7tuc, 8esh - hMHC I (mutant) + -2-microglobulin + peptide
    
  • 6mpp - hMHC I + -2-microglobulin + peptide – NMR
    
  • 7ejl, 7ejn, 7eu2, 7f4w, 7lfz, 7lg0, 7lg2, 7lg3, 7lgd, 7kgo, 7kgp, 7kgq, 7kgr, 7kgs, 7kgt, 7m8s, 7m8t, 7m8u, 7mkb, 7n1a, 7n1b, 7n6d, 7p3d, 7p3e, 7rtd, 7sa2, 7u1r, 7um2, 7ur1 - hMHC I + -2-microglobulin + SARS protein peptide
    
  • 7n19 - hMHC I +b + -2-microglobulin + peptide
    
  • 1n2r, 1syv - hMHC I + -2-microglobulin + hMHC II peptide
    
  • 4emz - hMHC I + NEF + peptide
    
  • 4nqe, 4pjc, 7lli - hMHC I + -2-microglobulin + TCR
    
  • 4pj9 - hMHC I (mutant) + -2-microglobulin + TCR
    
  • 8esb - hMHC I /-2-microglobulin/peptide – Cryo EM
    

• Non-human MHC I ternary complex

• • 4zus - hoMHC I + -2-microglobulin + peptide – horse
    
  • 3pwv - MHC I + -2-microglobulin + peptide – bovine
    
  • 3jts, 6hwj - rmMHC I + -2-microglobulin + peptide – Rhesus macaque
    
  • 6lah, 6lam, 6lb2, 6lt6 - rmMHC I (mutant) + -2-microglobulin + lysophospholipid
    
  • 3qq3, 3qq4, 5h94, 5nq1, 6a6h, 6kwk, 6kwl, 6kwo, 6lf8, 6lf9, 7em9, 7ema, 7emb, 7emc, 7emd, 8gqv, 8gqw - pMHC I + -2-microglobulin + peptide – pig
    
  • 6kwn - pMHC I (mutant) + -2-microglobulin + peptide
    
  • 1kjv, 1kjm, 1ed3 – MHC I + -2-microglobulin + peptide - rat
    
  • 2oi9 - mMHC I + T cell receptor + peptide
    

1bz9, 1ffn, 1ffo, 1ffp, 1fg2, 1g7p, 1g7q, 1hoc, 1juf, 1jpf, 1jpg, 1k8d, 1kbg, 1kpu, 1kpv, 1inq, 1ld9, 1lek, 1leg, 1lk2, 1n3n, 1n59, 1n5a, 1nan, 1qlf, 1rjy, 1rjz, 1rk0, 1rk1, 1s7q, 1s7r, 1s7s, 1s7t, 1s7u, 1s7v, 1s7w, 1s7x, 1t0m, 1t0n, 1vac, 1vad, 1vgk, 1wbx, 1wby, 1wbz, 1yn6, 1yn7, 1zhb, 1zt1, 1zt7, 2cii, 2e7l, 2f74, 2ffo, 2mha, 2ve6, 2zok, 2zol, 2zsv, 2zsw, 3buy, 3cc5, 3cch, 3ch1, 3cpl, 3e6f, 3ecb, 3ftg, 3fol, 3l3h, 3quk, 3qul, 3rol, 3roo, 3tbs, 3tbt, 3tbv, 3tbw, 3tid, 3tie, 3tby, 4nsk, 4pg9, 4pgd, 4pge, 5j6h, 5opi, 5ts1, 6g9r, 6gb5, 6gb6, 6gb7, 6jq2, 6jq3, 6npr, 6x00, 7lfi, 7n5q, 8d5j - mMHC I + -2-microglobulin + peptide

• • 2qri - mMHC I/-2-microglobulin/peptide
    
  • 2qrs, 2qrt - mMHC I (mutant)/-2-microglobulin/peptide
    
  • 1ddh, 1fzj, 1fzk, 1fzm, 1fzo, 1mhc, 2clv, 2clz, 7lfj - mMHC I (mutant) + -2-microglobulin + peptide
    
  • 6bga, 6wl2, 6wl3, 6wl4 - mMHC I + T cell receptor + peptide
    
  • 3e2h, [[3e3q - mMHC I (mutant) + T cell receptor + peptide
    
  • 1nez - mMHC I + -2-microglobulin + CD8 chain
    
  • 7dc6 – MHC I + -2-microglobulin + peptide – panda
    
  • 5f1n, 7cjq – MHC I + -2-microglobulin + peptide – dog
    
  • 6m24, 6m2j, 6m2k – MHC I + -2-microglobulin + peptide – rabbit
    
  • 7edo – MHC I + -2-microglobulin + peptide – possum
    
  • 6a2b – MHC I + -2-microglobulin + peptide – frog
    
  • 6j2d, 6j2e, 6j2g, 6j2h, 6j2i, 6j2j, 6k7t – MHC I + -2-microglobulin + peptide – bat
    
  • 7cpo – MHC I + -2-microglobulin + peptide – Anolis carolinensis
    
  • 6ilc, 6ile, 6ilf, 6ilg – MHC I + -2-microglobulin + peptide – flying fox
    
  • 2yez, 3bev, 3bew, 3rwc, 3rwd, 3rwe, 3rwf, 3rwg, 3rwh, 3rwi, 3rwj, 4cvx, 4cvz, 4d0b, 4d0c, 4d0d, 4cw1, 4zfz, 5ad0, 6iwg, 6irl, 6kx9, 6lhf, 6lhg, 6lhh, 7wbg, 7wbi – cMHC I + -2-microglobulin + peptide
    
  • 4e0r, 4g42 – cMHC I (mutant) + -2-microglobulin + peptide
    
  • 7zqj, 7zqi – MHC I + -2-microglobulin + peptide – warbler
    
  • 6kyu – MHC I + -2-microglobulin + peptide – duck
    
  • 5h5z, 6lbe – MHC I + -2-microglobulin + peptide – bony fish
    
  • 6lup – MHC I + -2-microglobulin + peptide – shark
    

• MHC I quaternary complex

• • 1lp9, 1ml5, 1oga, 1qrn, 2bnq, 2bnr, 2esv, 2f53, 2f54, 2gj6, 2j8u, 2p5e, 2p5w, 2pye, 2vlj, 2vlk, 2vll, 2vlr, 3d39, 3d3v, 3ffc, 3gsn, 3h9s, 3mv7, 3mv9, 3o4l, 3qdg, 3qdj, 3qdm, 3qeq, 3vxm, 3vxs, 4eup, 4ftv, 4jfd, 4jry, 4mji, 4pri, 4qrp, 5brz, 5c08, 5e9d, 5nmf, 5wkh, 6amu, 6avf, 6avg, 6bj2, 6bj3, 6bj8, 6d78, 6dkp, 6eqa, 6eqb, 6g9q,6mt3, 6mt4, 6mt5, 6mt6, 6mtm, 6pue, 6puf, 6pug, 6pui, 6puj, 6puk, 6pul, 6pum, 6pvc, 6pvd, 6px6, 6q3s, 6r2l, 6rsy, 6tmo, 6tro, 6uk2, 6uk4, 6uln, 6ulr, 6uon, 6uz1, 6vm7, 6vm8, 6vm9, 6vqo, 6vma, 6vmc, 6vmx, 6vrm, 6vrn, 6zky, 7dzm, 7dzn, 7lfk, 7lfl, 7lfm, 7n1e, 7n1f, 7n6e, 7nme, 7nmf, 7nmg, 7ow5, 7ow6, 7pb2, 7q99, 7q9a, 7qpj, 7r80, 7rk7, 7rtr, 7su9, 8cx4, 8gvb, 8gvg, 8gvi - hMHC I + T cell receptor + -2-microglobulin + peptide
    
  • 2jcc, 2uwe, 3kxf, [[3mv8 - hMHC I (mutant) + T cell receptor + -2-microglobulin + peptide
    
  • 7pbe, 8gom, 8gon - hMHC I + T cell receptor + -2-microglobulin + SARS peptide
    
  • 7phr, 8es8, 8es9 - hMHC I + T cell receptor + -2-microglobulin + peptide + CD3 – Cryo EM
    
  • 1im9, 1p7q, 6ewc - hMHC I + leukocyte
    immunoglobulin-like receptor + -2-microglobulin + peptide
    
  • 5t6z, 6v3j, 7k80, 7k81 - hMHC I + KIR3DL1 + -2-microglobulin + peptide
    
  • 6pa1 - hMHC I + KIR2DL2 + -2-microglobulin + peptide
    
  • 6pag - hMHC I + KIR2DL3 + -2-microglobulin + peptide
    
  • 6aee, 6k60 - hMHC I + LIR-1 + -2-microglobulin + peptide
    
  • 6ewo - hMHC I + LIR-1 + synemin + -2-microglobulin + peptide
    
  • 6ewa - hMHC I + LIR-1 + polyprotein + -2-microglobulin
    
  • 7qng - hMHC I + protein disulfide isomerase + tapasin + -2-microglobulin
    
  • 6eny, 7qpd - hMHC I + calreticulin + protein disulfide isomerase + tapasin + -2-microglobulin – Cryo EM
    
  • 2dyp - hMHC I (mutant) + leukocyte immunoglobulin-like receptor + -2-microglobulin + peptide
    
  • 1akj, 1bqh, 3dmm, [[3qzw - hMHC I + -2-microglobulin + CD8 + peptide
    
  • 1im3 - hMHC I + -2-microglobulin + cytomegalovirus protein US2 + peptide
    
  • 3cdg, 3cii - hMHC I + -2-microglobulin + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide
    
  • 1w72, 3cvh, 3gjf, 3hae, 5d2n, 6id4, 6uj9, 6w51, 7bbg, 7bh8, 7re7, 8eb2 - hMHC I + -2-microglobulin + antibody + peptide
    
  • 7t0l - hMHC I (mutant) + -2-microglobulin + antibody + peptide
    
  • 7sr3, 7sr5, 7srk - hMHC I /-2-microglobulin/peptide + Vhh
    
  • 7duu - hMHC I + -2-microglobulin + KIR receptor + peptide
    
  • 4e5x - hMHC I + -2-microglobulin + E3-19K + peptide
    
  • 7byd - rmMHC I + -2-microglobulin + TCR + peptide
    
  • 1fo0, 1g6r, 1mwa, 1nam, 2ckb, 2z31, 3pqy, 7jwi - mMHC I + T cell receptor + -2-microglobulin + peptide
    
  • 2oi9 - mMHC I (mutant) + T cell receptor + -2-microglobulin + peptide
    
  • 1p1z, 1p4l, 1qo3, 5j6g - mMHC I + -2-microglobulin + natural killer cell receptor LY49C + peptide
    
  • 3c8k - mMHC I (mutant) + -2-microglobulin + natural killer cell receptor LY49C + peptide
    

• MHC II

• • 1hdm, 2bc4, 3lqz, 4p4r - hMHC II +
    
  • 1a6a, 3pdo, 3pgc, 3pgd, 5ksu - hMHC II ++
    
  • 1fng, 1lnu, 3cup, 2p24 - mMHC II +
    
  • 1fne - mMHC II + (mutant)
    
  • 3lqz - hMHC II + DP2
    
  • 6t3y, 7apz - cMHC II +
    

• MHC II binary complex

• • 1h15 - hMHC II + + DNA polymerase peptide
    
  • 1fv1 - hMHC II + + myelin basic protein
    
  • 2wbj, 3o6f, 4grl, 6mnn, 6mno - hMHC II + + T cell receptor
    
  • 1fv1, 1h15, 1s9v, 1t5w]], 1uvq, 2fse, 2q6w, 3l6f, 3c5j, 4h25, 4md0, 4md5, 5nig, 6atf, 6atz, 6bij, 6bil, 6bin, 6biv, 6bix, 6biy, 6blq, 6dig, 6hby, 6nix, 6qzc, 6qzd, 6u3m, 6zwa, 7kei, 7t2a, 7t6i, 7yx9, 7yxb, 7zak, 7zfr – hMHC II + + peptide
    
  • 1dlh - hMHC II + + enterotoxin
    
  • 8euq - hMHC II + + antibody
    
  • 3c5z, 3c60, 3c6l, 3rdt, 6dfs, 6dfw, 6mkd, 6mkr, 6py2 - mMHC II + + T cell receptor
    
  • 1r5v, 1k2d, 1muj, 1kt2, 1ktd, 1f3j, 1es0, 1iak, 1iea, 1ieb, 1f3j, 7qhp - mMHC II + + peptide
    
  • 1aqd - mMHC II + + MHC I peptide
    
  • 1l3r, 1r5w - mMHC II + (mutant) + peptide
    
  • 6kvm, 7pdy – cMHC II + + peptide
    

• MHC II ternary complex

• • 1zgl, 1j8h, 1fyt, 1ymm, 2iam, 2ain, 4z7u, 6cql, 6cqn, 6dfx, 6mng, 6mnm, 6r0e, 6u3n, 6u3o, 6v15, 6xc9, 6xco, 7sg0, 7sg1, 7sg2, 7t2b, 7t2c, 7t2d - hMHC II + + T cell receptor + peptide
    
  • 6xp6 - hMHC II + + antibody+ peptide
    
  • 1d5m, 1d5x, 1d5z, 1d6e, 1hxy, 1jwm, 1jws, 1jwu, 1klg, 1klu, 1pyw, 1seb, 2seb, 2g9h, 2ipk - hMHC II + + enterotoxin + peptide
    
  • 1sje, 1sjh, 1t5x, 1lo5 - hMHC II + + enterotoxin (mutant) + peptide
    
  • 1r5i - hMHC II + + mycoplasma arthritidis mitogen+ peptide
    
  • 2oje - mMHC II + + mycoplasma arthritidis mitogen+ peptide
    
  • 1zgl, 2xn9, 3mbe, 3qib, 3qiu, 3qiw, 7rdv - mMHC I + T cell receptor + peptide
    
  • 1u3h, 2pxy - mMHC II + + T cell receptor (mutant) + peptide
    
  • 1jl4 - mMHC II + + CD4 + peptide
    

• MHC II quaternary complex

• • 4c56 - hMHC II + + T cell receptor + enterotoxin + hemagglutinin peptide
    
  • 3pl6, 5nme, 6rp9, 6rpa, 6rpb - hMHC II + T cell receptor + -2-microglobulin + peptide
    
  • 3s4s - hMHC II + + CD4 + hemagglutinin peptide
    
  • 2icw - mMHC II + + T cell receptor + mycoplasma arthritidis mitogen+ hemagglutinin peptide
    

}}

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky