Hydroxysteroid dehydrogenase 3D structures: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
Michal Harel (talk | contribs)
32,831 edits
No edit summary
Fix TreeAndMenu broken list structure
Line 3: Line 3:
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
*3-α HSD or AKR1C2
*3-α HSD or AKR1C2


'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
**[[1ral]] – rHSD – rat<BR />
**[[1ral]] – rHSD – rat<BR />
**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />
**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />
Line 13: Line 11:
**[[7p36]], [[8kc6]] - LkHSD – ''Lactobacillus kefiri''<br />
**[[7p36]], [[8kc6]] - LkHSD – ''Lactobacillus kefiri''<br />
**[[8kcn]] - LkHSD (mutant)<br />
**[[8kcn]] - LkHSD (mutant)<br />
*''3-α HSD binary complex''
*''3-α HSD binary complex''
**[[2fvl]], [[2hdj]] - hHSD + NADP - human<BR />
**[[2fvl]], [[2hdj]] - hHSD + NADP - human<BR />
**[[1lwi]] – rHSD + NADP<BR />
**[[1lwi]] – rHSD + NADP<BR />
Line 22: Line 18:
**[[4is3]] - CsHSD + NAD<br />
**[[4is3]] - CsHSD + NAD<br />
**[[7ejh]], [[7eji]], [[7ejj]], [[7vdo]], [[7vet]] - LkHSD (mutant`) + NADP <br />
**[[7ejh]], [[7eji]], [[7ejj]], [[7vdo]], [[7vet]] - LkHSD (mutant`) + NADP <br />
*''3-α HSD ternary complex''
*''3-α HSD ternary complex''
**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP <br />
**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP <br />
**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
*3-α HSD type 3
*3-α HSD type 3
**[[2hdj]] - hHSD + NADP<br />
**[[2hdj]] - hHSD + NADP<br />
**[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP <br />
**[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP <br />
Line 36: Line 28:
**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />
**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />
**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br />
**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br />
*7-α HSD  
*7-α HSD  
**[[3gaf]] - BmHSD – ''Brucella melitensis''<BR />
**[[3gaf]] - BmHSD – ''Brucella melitensis''<BR />
**[[8hax]], [[8hde]], [[8hdi]], [[8hdn]], [[8hs6]], [[8hs9]] - BmHSD (mutant)<BR />
**[[8hax]], [[8hde]], [[8hdi]], [[8hdn]], [[8hs6]], [[8hs9]] - BmHSD (mutant)<BR />
Line 46: Line 36:
**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD<br />
**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD<br />
**[[5epo]] – HSD + NADP – ''Clostridium sardiniese''<br />
**[[5epo]] – HSD + NADP – ''Clostridium sardiniese''<br />
*7-beta HSD   
*7-beta HSD   
**[[5fyd]] – CaHSD – ''Collinsella aerofaciens<''br />
**[[5fyd]] – CaHSD – ''Collinsella aerofaciens<''br />
**[[5gt9]] – CaHSD + NADP<br />
**[[5gt9]] – CaHSD + NADP<br />
*20-α HSD or AKR1C1  
*20-α HSD or AKR1C1  
**[[6a7a]], [[8jp2]] – hHSD + NADP + inhibitor<br />
**[[6a7a]], [[8jp2]] – hHSD + NADP + inhibitor<br />
**[[1q5m]] - raHSD + NADP – rabbit
**[[1q5m]] - raHSD + NADP – rabbit
*''20-α HSD  ternary complex''
*''20-α HSD  ternary complex''
**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br />
**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br />
Line 65: Line 49:
**[[6ijx]] – hHSD + NADP + meclofenamic acid<br />
**[[6ijx]] – hHSD + NADP + meclofenamic acid<br />
**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />
**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />
*20-beta HSD   
*20-beta HSD   
**[[6m9u]] – BaHSD – ''Bifidobacterium adolescentis''<br />
**[[6m9u]] – BaHSD – ''Bifidobacterium adolescentis''<br />
**[[6ow4]] – BaHSD + NADP <br />
**[[6ow4]] – BaHSD + NADP <br />
*11-β HSD or corticosteroid  11-β-dehydrogenase 1
*11-β HSD or corticosteroid  11-β-dehydrogenase 1
**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
**[[2pd6]] - hHSD + NAD<BR />
**[[2pd6]] - hHSD + NAD<BR />
Line 80: Line 60:
**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />
**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />
*''11-β HSD  ternary complex''
*''11-β HSD  ternary complex''
**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]], [[4yyz]]  - hHSD 1 + inhibitor + NADP<BR />
**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]], [[4yyz]]  - hHSD 1 + inhibitor + NADP<BR />
Line 91: Line 69:
**[[4k26]], [[5qij]] - mHSD 1 + inhibitor + NADP<br />
**[[4k26]], [[5qij]] - mHSD 1 + inhibitor + NADP<br />
**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />
**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />
*17-α HSD or AKR1C21
*17-α HSD or AKR1C21
**[[2he8]] – mHSD - mouse <br />
**[[2he8]] – mHSD - mouse <br />
**[[3fjn]] - mHSD (mutant) <br />
**[[3fjn]] - mHSD (mutant) <br />
Line 100: Line 76:
**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />
**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />
**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />
**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />
*17-β HSD or estradiol 11-β-dehydrogenase 1
*17-β HSD or estradiol 11-β-dehydrogenase 1


'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]
'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]
**[[1bhs]] – hHSD 1 <BR />
**[[1bhs]] – hHSD 1 <BR />
**[[1s9c]] - hHSD 4 (mutant) <BR />
**[[1s9c]] - hHSD 4 (mutant) <BR />
Line 111: Line 85:
**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
**[[3itd]] - ClHSD (mutant)
**[[3itd]] - ClHSD (mutant)
*''17-β HSD binary complex''
*''17-β HSD binary complex''
**[[1fds]], [[1iol]], [[1jtv]], [[1yb1]], [[3dhe]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br />
**[[1fds]], [[1iol]], [[1jtv]], [[1yb1]], [[3dhe]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br />
**[[1dht]], [[1fdw]] - hHSD (mutant) + hydroxysteroid<BR />
**[[1dht]], [[1fdw]] - hHSD (mutant) + hydroxysteroid<BR />
Line 127: Line 99:
**[[3qwf]] - ClHSD + NADP<BR />
**[[3qwf]] - ClHSD + NADP<BR />
**[[4fiz]], [[4fj0]], [[4fj1]], [[4fj2]] – ClHSD + dehydroxy flavonoid inhibitor<br />
**[[4fiz]], [[4fj0]], [[4fj1]], [[4fj2]] – ClHSD + dehydroxy flavonoid inhibitor<br />
*''17-β HSD ternary complex''
*''17-β HSD ternary complex''
**[[1fdt]], [[1qyw]], [[1qyx]] - hHSD 1 + hydroxysteroid + NADP<BR />
**[[1fdt]], [[1qyw]], [[1qyx]] - hHSD 1 + hydroxysteroid + NADP<BR />
**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />
**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />
Line 144: Line 114:
**[[5hs6]] - hHSD 14 + NAD + estrone<br />
**[[5hs6]] - hHSD 14 + NAD + estrone<br />
**[[3qwh]], [[3qwi]] - ClHSD + hydroxysteroid + NADP<BR />
**[[3qwh]], [[3qwi]] - ClHSD + hydroxysteroid + NADP<BR />
*3-α 20-β HSD
*3-α 20-β HSD
**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />
**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />
**[[1hdc]] – SeHSD + inhibitor
**[[1hdc]] – SeHSD + inhibitor
*Carbonyl reductase/20-β HSD
*Carbonyl reductase/20-β HSD
**[[1n5d]]  - HSD + NADP – pig<br />
**[[1n5d]]  - HSD + NADP – pig<br />
*3-β/17-β HSD
*3-β/17-β HSD
**[[1hxh ]] - CtHSD
**[[1hxh ]] - CtHSD
}}
}}


[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:42, 29 March 2026

3D structures of hydroxysteroid dehydrogenase

Updated on 29-March-2026

For 3-α HSD type 2 see Prostaglandin F synthase

    • 1ral – rHSD – rat
    • 1fjh - CtHSD – Comamonas testosterone
    • 4is2 – CsHSD – Clostridium scindens
    • 7p36, 8kc6 - LkHSD – Lactobacillus kefiri
    • 8kcn - LkHSD (mutant)
  • 3-α HSD binary complex
  • 3-α HSD ternary complex
  • 3-α HSD type 3
    • 2hdj - hHSD + NADP
    • 1ihi, 1j96 - hHSD + hydroxysteroid + NADP
    • 1xjb - hHSD + citrate+ acetate + NADP
    • 4l1w - hHSD + progesterone + NADP
    • 4l1x - hHSD (mutant) + progesterone + NADP
    • 4xo6, 4xo7 – hHSD + NADP + epiandrosterone derivative
  • 7-α HSD
  • 7-beta HSD
    • 5fyd – CaHSD – Collinsella aerofaciens<br />
    • 5gt9 – CaHSD + NADP
  • 20-α HSD or AKR1C1
    • 6a7a, 8jp2 – hHSD + NADP + inhibitor
    • 1q5m - raHSD + NADP – rabbit
  • 20-α HSD ternary complex
    • 1mrq – hHSD + hydroxysteroid + NADP
    • 4yvp – hHSD + NADP + sulfonylurea derivative
    • 3c3u, 3nty - hHSD + inhibitor + NADP
    • 3gug - hHSD (mutant) + inhibitor + NADP
    • 6ijx – hHSD + NADP + meclofenamic acid
    • 1q13 - raHSD + hydroxysteroid + NADP
  • 20-beta HSD
    • 6m9u – BaHSD – Bifidobacterium adolescentis
    • 6ow4 – BaHSD + NADP
  • 11-β HSD or corticosteroid 11-β-dehydrogenase 1
    • 1xu7, 1xu9 - hHSD (mutant) + NADP
    • 2pd6 - hHSD + NAD
    • 3hb4 - hHSD + inhibitor
    • 3dey - hHSD + hydroxysteroid
    • 1y5m - mHSD + NADP - mouse
    • 1xse - gpHSD catalytic domain + NADP – guinea pig
    • 3dwf, 3lz6 - gpHSD catalytic domain (mutant) + NADP
  • 11-β HSD ternary complex
  • 17-α HSD or AKR1C21
    • 2he8 – mHSD - mouse
    • 3fjn - mHSD (mutant)
    • 2he5, 2hej, 2p5n - mHSD + NADP
    • 2ipf - mHSD + hydroxysteroid + NADP
    • 2ipg, 2ipj - mHSD (mutant) + hydroxysteroid + NADP
    • 3cv6 - mHSD (mutant) + inhibitor + NADP
  • 17-β HSD or estradiol 11-β-dehydrogenase 1

For 17-β HSD type 5 or AKR1C3 see Prostaglandin F synthase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Openfox

Retrieved from "https://proteopedia.org/index.php?title=Hydroxysteroid_dehydrogenase_3D_structures&oldid=4433665"