1uk1: Difference between revisions

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{{Seed}}
[[Image:1uk1.png|left|200px]]
[[Image:1uk1.png|left|200px]]


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{{STRUCTURE_1uk1|  PDB=1uk1  |  SCENE=  }}  
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===Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor===
===Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor===


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{{ABSTRACT_PUBMED_15293985}}
{{ABSTRACT_PUBMED_15293985}}


==About this Structure==
==About this Structure==
1UK1 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UK1 OCA].  
[[1uk1]] is a 2 chain structure of [[Poly (ADP-ribose) polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UK1 OCA].  
 
==See Also==
*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]


==Reference==
==Reference==
<ref group="xtra">PMID:15293985</ref><references group="xtra"/>
<ref group="xtra">PMID:015293985</ref><ref group="xtra">PMID:015690493</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kinoshita, T.]]
[[Category: Kinoshita, T.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
 
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 16:10:20 2009''

Revision as of 22:26, 26 July 2012

File:1uk1.png

Template:STRUCTURE 1uk1

Crystal structure of human poly(ADP-ribose) polymerase complexed with a potent inhibitor

Template:ABSTRACT PUBMED 15293985

About this Structure

1uk1 is a 2 chain structure of Poly (ADP-ribose) polymerase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Hattori K, Kido Y, Yamamoto H, Ishida J, Kamijo K, Murano K, Ohkubo M, Kinoshita T, Iwashita A, Mihara K, Yamazaki S, Matsuoka N, Teramura Y, Miyake H. Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase. J Med Chem. 2004 Aug 12;47(17):4151-4. PMID:15293985 doi:10.1021/jm0499256
  2. Pang YP. Three-dimensional model of a substrate-bound SARS chymotrypsin-like cysteine proteinase predicted by multiple molecular dynamics simulations: catalytic efficiency regulated by substrate binding. Proteins. 2004 Dec 1;57(4):747-57. PMID:15690493 doi:10.1002/prot.20249

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