3ubx: Difference between revisions
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{{STRUCTURE_3ubx| PDB=3ubx | SCENE= }} | {{STRUCTURE_3ubx| PDB=3ubx | SCENE= }} | ||
===Crystal structure of the mouse CD1d-C20:2-aGalCer-L363 mAb Fab complex=== | ===Crystal structure of the mouse CD1d-C20:2-aGalCer-L363 mAb Fab complex=== | ||
{{ABSTRACT_PUBMED_22110136}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref> [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | |||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Beta-2 microglobulin|Beta-2 microglobulin]] | *[[Beta-2 microglobulin|Beta-2 microglobulin]] | ||
*[[CD1|CD1]] | |||
==Reference== | |||
<ref group="xtra">PMID:022110136</ref><references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Yu, E D.]] | [[Category: Yu, E D.]] | ||
Revision as of 05:44, 28 August 2013
Crystal structure of the mouse CD1d-C20:2-aGalCer-L363 mAb Fab complex
Template:ABSTRACT PUBMED 22110136
Function
[CD1D1_MOUSE] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.[1] [2] [3] [B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
About this Structure
3ubx is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
See Also
Reference
- Yu ED, Girardi E, Wang J, Mac TT, Yu KO, Van Calenbergh S, Porcelli SA, Zajonc DM. Structural basis for the recognition of C20:2-alphaGalCer by the invariant natural killer T cell receptor-like antibody L363. J Biol Chem. 2012 Jan 6;287(2):1269-78. Epub 2011 Nov 22. PMID:22110136 doi:10.1074/jbc.M111.308783
- ↑ Jayawardena-Wolf J, Benlagha K, Chiu YH, Mehr R, Bendelac A. CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity. 2001 Dec;15(6):897-908. PMID:11754812
- ↑ Zajonc DM, Maricic I, Wu D, Halder R, Roy K, Wong CH, Kumar V, Wilson IA. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. J Exp Med. 2005 Dec 5;202(11):1517-26. Epub 2005 Nov 28. PMID:16314439 doi:10.1084/jem.20051625
- ↑ Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nat Immunol. 2005 Aug;6(8):810-8. Epub 2005 Jul 10. PMID:16007091 doi:10.1038/ni1224
