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Line 1: <StructureSection load='3mrb' size='350' side='right' scene='' caption='Human β-2 microglobulin (green) complex with MHC I (grey) and HCMV PP65 nonapeptide (cyan), [[3mrb]]'>
<StructureSection load='3mrb' size='350' side='right' scene='' caption='Human β-2 microglobulin (green) complex with MHC I (grey) and HCMV PP65 nonapeptide (cyan), [[3mrb]]'>
[[Image:MHC Class 1.png|thumb|200px|right|Diagram of MHC I Complex]]
[[Beta-2 microglobulin]] ('''B2M''') is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess. For more details, see: [[Human beta two microglobulin]].
[[Beta-2 microglobulin]] ('''B2M''') is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess. For more details, see: [[Human beta two microglobulin]].
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[[Image:MHC Class 1.png|thumb|200px|right|Diagram of MHC I Complex]]
== Disease ==
== Disease ==
Revision as of 08:41, 1 December 2015
Beta-2 microglobulin (B2M ) is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess. For more details, see: Human beta two microglobulin .
Diagram of MHC I Complex Disease Elevated B2M levels are found in patients of live cirhossis.
Relevance B2M is used as a marker for certain types of blood cell cancer. It can indicate the spread and severity of myeloma.
3D Structures of β-2 microglobulin Updated on 01-December-2015
{"openlevels":0}
B2M
Human beta two microglobulin , 3myz , 3ib4 , 3ekc , 3dhj , 3dhm , 3ciq , 2z9t , 2d4d , 2f8o , 1py4 , **3ov6 , 3tlr , 3tm6 , 4fxl - hβ-2-microglobulin (mutant) – human3qda - hβ-2-microglobulin residues 21-119 (mutant) 2xks , 2xku , 1jnj - hβ-2-microglobulin – NMR2vb5 - hβ-2-microglobulin (mutant) – NMR2e8d - hβ-2-microglobulin residues 40-61 - NMR3low , 2yxf , 2d4f , 1lds - hβ-2-microglobulin3gbl - β-2-microglobulin residues 1-97 - grass carp1bmg - bβ-2-microglobulin - bovine3loz - β-2-microglobulin – synthetic3o81 - cβ-2-microglobulin - chicken1cd1 - mβ-2-microglobulin - mouse4m9o - β-2-microglobulin – zebra fishB2M in binary complex with MHC
1zs8 , 1u58 - mβ-2-microglobulin + mMHC I – mouse1r3h - mβ-2-microglobulin + mMHC II extracellular domain2hla , 3hla , 1hla - hβ-2-microglobulin + hMHC I4gup - hβ-2-microglobulin + hMHC I (mutant)3p73 , 3p77 - cβ-2-microglobulin + cMHC I 1pdq - mβ-2-microglobulin + MCMV M1441z5l , 3au1 - mβ-2-microglobulin + CD1D4f7c , 4f7e - bβ-2-microglobulin + CD1DB2M in binary complex with CD1
3s6c - hβ-2-microglobulin/hCD1E4x6e - hβ-2-microglobulin + CD1A3t8x - hβ-2-microglobulin + hCD1B3u0p - hβ-2-microglobulin + hCD1D (mutant)3ma7 , 3ilp , 3ilq , 3g08 , 3gml , 3gmm , 3gmn , 3gmo , 3gmp , 3gmq , 3gmr , 1zhn , 3t1f , 4mq7 , 4mx7 - mβ-2-microglobulin + CD1D12gaz , 2fik - mβ-2-microglobulin + CD1D1 extracellular domain2akr - mβ-2-microglobulin residues 21-119+ CD1D1 extracellular domain2h26 - hβ-2-microglobulin + CD1B extracellular domain3l9r - bβ-2-microglobulin + CD1B33jvg - cβ-2-microglobulin + CD1A1 ectodomainB2M in binary complex with other molecules
1exu - hβ-2-microglobulin + Fc receptor3fru - rβ-2-microglobulin + Fc receptor - rat1c16 - mβ-2-microglobulin + protein T221a6z - hβ-2-microglobulin + hemochromatosis protein2x89 - hβ-2-microglobulin + antibody4kdt - hβ-2-microglobulin + nanobody3mzt - hβ-2-microglobulin + thioflavin1pqz - mβ-2-microglobulin + MCMV M1444iiq , 4l8s , 4l9l , 4lcc , 4lcw - bβ-2-microglobulin + Tc receptorB2M in ternary complex with MHC
2yf6 , 3bew , 4e0r , 4g42 , 4g43 – cβ-2-microglobulin + cMHC I α + peptide2xfx - bβ-2-microglobulin + MHC I α + peptide3jts , 3jtt , 1zvs , 3rwc , 3rwd , 3rwe , 3rwf , 3rwg , 3rwh , 3rwi , 3rwj - β-2-microglobulin + MHC I α + peptide – Macaca mulatta3kpn , 3kpo – hβ-2-microglobulin + hMHC I B + peptide3bev , 1kpr , 1k5n , 3nfn , 3mr9 , 3mrb , 3mrc , 3mrd , 3mre , 3mrf , 3mrg , 3mrh , 3mri , 3mrj , 3mrk , 3mrl , 3mrm , 3mrn , 3mro , 3mrp , 3mrq , 3mrr , 3ox8 , 3oxr , 3oxs , 2xpg , 3pwj , 3pwl , 3pwn , 3pwp , 2x70 , 3o3a , 3o3b , 3o3d , 3o3e , 3lv3 , 3ln4 , 3ln5 , 3myj , 3i6l , 3lkn , 3lko , 3lkp , 3lkq , 3lkr , 3lks , 3hpj , 3i6g , 3i6k , 3mgo , 3mgt , 3l3d , 3l3g , 3l3h , 3l3i , 3l3j , 3l3k , 2x4n , 2x4o , 2x4p , 2x4q , 2x4r , 2x4s , 2x4t , 2x4u , 3lka , 3h7b , 3kpl , 3kpm , 3kpn , 3kpo , 3kpp , 3kpq , 3kpr , 3kps , 3giv , 3hcv , 3d18 , 3dtx , 3czf , 3fqn , 3fqr , 3fqt , 3fqu , 3fqw , 3fqx , 3d25 , 3bvn , 3dx6 , 3dx7 , 3dx8 , 3dxa , 3bo8 , 3bp4 , 3bp7 , 3bgm , 3bh8 , 3bh9 , 3bhb , 3b3i , 3b6s , 2rfx , 3bze , 3bzf , 3bw9 , 3bwa , 3c9n , 2v2w , 2v2x , 2gt9 , 2gtw , 2gtz , 2guo , 2nw3 , 2fyy , 2fz3 , 2hn7 , 2cik , 2git , 2hjk , 2hjl , 2h6p , 2d31 , 2c7u , 2bck , 2a83 , 2axf , 2axg , 2bvo , 2bvp , 2bvq , 1s8d , 1t1w , 1t1x , 1t1y , 1t1z , 1t20 , 1t21 , 1t22 , 1s7q , 1zsd , 2bsr , 2bss , 2bst , 1zhk , 1zhl , 1tvb , 1tvh , 1xr8 , 1xr9 , 1w0v , 1w0w , 1xh3 , 1uxs , 1uxw , 1s9w , 1s9x , 1s9y , 1q94 , 1qvo , 1n2r , 1ogt , 1qew , 1jge , 1k5n , 1i7r , 1i7t , 1i7u , 1jf1 , 1jht , 1i4f , 1e27 , 1e28 , 1i1y , 1i1f , 1qqd , 1mhe , 1b0g , 1a9b , 1a9e , 1a1m , 1a1n , 1a1o , 1tmc , 2clr , 1hhg , 1hhh , 1hhi , 1hhj , 1hhk , 1hsb , 1hsa , 3kla , 3giv , 3d18 , 3bxn , 1x7q , 1ydp , 1sys , 1of2 , 1jgd , 1eey , 1eez , 1duy , 1duz , 1agb , 1agc , 1agd , 1age , 1agf , 3am8 , 3qfd , 3rew , 3rl1 , 3rl2 , 3skm , 3sko , 3utq , 3uts , 3utt , 3vfm , 3vfn , 3vfo , 3vfp , 3vfr , 3vfs , 3vft , 3vfu , 3vfv , 3vfw , 3vh8 , 2ypk , 3spv , 3tid , 3tie , 3to2 , 3upr , 3v5d , 3v5h , 3v5k , 3vcl , 3vri , 3vrj , 4f7m , 4f7p , 4f7t , 4gks , 4i4w , 3w39 , 4g8i , 4g9d , 4jqv , 4jqx , 4k7f , 1b0r , 3vxm , 3vxn , 3vxo , 3vxp , 3vxr , 3vxs , 3vxu , 3w0w , 4hwz , 4hx1 , 4i48 , 4nqv , 4nqx , 3wl9 , 3wlb , 3ws3 , 3ws6 , 3x11 , 3x12 , 3x13 , 3x14 , 4hs3 , 4lcy , 4lnr , 4mj5 , 4mj6 , 4nnx , 4nny , 4no2 , 4no3 , 4no5 , 4nt6 , 4o2c , 4o2e , 4o2f , 4pr5 , 4pra , 4prb , 4prd , 4pre , 4prn , 4qrq , 4qrs , 4qrt , 4qru , 4u6x , 4u6y , 4uq2 , 4uq3 , 4wj5 - hβ-2-microglobulin + hMHC I α + peptide4l29 , 4l3c - hβ-2-microglobulin + hMHC I α + NY-ES011ktl , 3kww , 3h9h , 3ixa , 3gso , 3gsq , 3gsr , 3gsu , 3gsv , 3gsw , 3gsx , 3ft2 , 3ft3 , 3ft4 , 2av1 , 2av7 , 1cg9 , 1m05 , 1m6o , 1kpr , 1ktl , 3kyn , 3kyo , 1qr1 - β-2-microglobulin + hMHC I α (mutant) + peptide1syv , 1n2r - β-2-microglobulin + hMHC I + hMHC II peptide1kjv , 1kjm , 1ed3 – rβ-2-microglobulin + MHC I α + peptide3bev , 3bew , 2yf6 , 2yf1 , 2yez , 2yf5 - cβ-2-microglobulin + cMHC I α + peptide1kbg , 3l3h , 3ftg , 3e6f , 3ecb , 3ch1 , 3cch , 3cc5 , 3cpl , 2zsv , 2zsw , 2zok , 2zol , 3buy , 2ve6 , 2e7l , 2fo4 , 2cii , 2fwo , 2f74 , 1zt1 , 1zt7 , 1vgk , 1yn6 , 1yn7 , 1zhb , 1wbx , 1wby , 1wbz , 1rjy , 1rjz , 1rk0 , 1rk1 , 1t0m , 1t0n , 1s7q , 1s7r , 1s7s , 1s7t , 1s7u , 1s7v , 1s7w , 1s7x , 1lk2 , 1kpu , 1kpv , 1n3n , 1nan , 1n59 , 1n5a , 1ffn , 1ffo , 1ffp , 1g7p , 1g7q , 1lek , 1leg , 1inq , 1juf , 1k8d , 1jpf , 1jpg , 1fg2 , 1qlf , 1bz9 , 1kbg , 1hoc , 2mha , 1vad , 1vac , 3fol , 3fom , 3fon , 1ce6 , 1osz , 1bii , 1ld9 , 2vaa , 2vab , 3p4m , 3p4n , 3p4o , 3p9l , 3p9m , 3pab , 3pwu , 3pwv , 3quk , 3qul , 3rol , 3roo , 3vj6 , 1ldp , 3tbs , 3tbt , 3tbv , 3tbw , 3tbx , 3tby , 4huu , 4huv , 4huw , 4hux , 4hv8 , 4nsk , 4pg2 , 4pg9 , 4pgb , 4pgc , 4pgd , 4pge , 4pv8 , 4pv9 - mβ-2-microglobulin + mMHC I + peptide2qri , 3nwm - mβ-2-microglobulin/mMHC I/peptide2qrs , 2qrt - mβ-2-microglobulin/mMHC I (mutant )/peptide1mhc , 2clv , 2clz , 1fzj , 1fzk , 1fzm , 1fzo , 1ddh , 4iho , 4l8b , 4l8c , 4l8d – mβ-2-microglobulin + mMHC I (mutant) + peptide1ypz - mβ-2-microglobulin + mMHC II + T cell receptorbr />4l4t , 4l4v , 4nqc , 4nqd , 4nqe , 5pj5 , 4pj7 , 5pj8 , 4pj9 , 5pja , 4pjb , 5pjc , 4pjd , 5pje , 4pjf , 5pjg , 4pjh , 5pji , 4pjx , 4prh , 4pri , 4wo4 - hβ-2-microglobulin + hMHC I + T cell receptor3qq3 , 3qq4 - β-2-microglobulin + MHC I + peptide - pig4gkn - β-2-microglobulin + MHC I + peptide – gorilla1nez - mβ-2-microglobulin + mMHC I + CD8 α chainB2M in ternary complex with CD1
3qux , 3quy , 3quz , 3o8x , 3o9w , 4mng , 3qi9 , 3scm , 3sda , 3sdc , 3ta3 , 3tn0 , 3to4 , 3tvm , 3sdd , 4elm , 3rtq , 3rzc , 4ei5 , 4apq - mβ-2-microglobulin + T cell receptor + CD1D12po6 , 3vwj , 3vwk , 4en3 , 3sdx , 3tzv , 4lhu - hβ-2-microglobulin + T cell receptor + CD1D14x6c , 4x6d - hβ-2-microglobulin + T cell receptor + CD1A3dbx - cβ-2-microglobulin + CD1-2 + fatty acid1zhn - mβ-2-microglobulin + CD1D1 + phosphatidylcholine1zt4 - mβ-2-microglobulin + CD1D1 + ceramide derivative3ubx , 4irj , 4irs - mβ-2-microglobulin + FAB + CD1D11xz0 - hβ-2-microglobulin + CD1A + lipopeptide1onq - hβ-2-microglobulin + CD1A + sulfatide4x6f - hβ-2-microglobulin + CD1A + sphingomyelin1uqs - hβ-2-microglobulin + CD1B + glycolipid1gzp , 1gzq - hβ-2-microglobulin + CD1B + ceramide derivative4ei5 - mβ-2-microglobulin + CD1D1 + T cell receptorB2M in ternary complex with other molecules
1i1a , 1frt - rβ-2-microglobulin + Fc receptor + Fc fragment1de4 - hβ-2-microglobulin + hemochromatosis protein + transferring receptor3m17 , 3m1b - hβ-2-microglobulin + FcRn+ peptide4k71 , 4n0f , 4n0u - hβ-2-microglobulin + serum albumin + Igg receptor P51B2M in quaternary complex with MHC
3qdg , 3qdj , 3qdm , 3qeq , 3mv7 , 3mv8 , 3mv9 , 3h9s , 3gsn , 3d39 , 3d3v , 3ffc , 2vlj , 2vlk , 2vll , 2vlr , 2j8u , 2p5e , 2p5w , 2pye , 2gj6 , 2f54 , 2esv , 2bnq , 2bnr , 1lp9 , 1oga , 1mi5 , 1qrn , 2nx5 , 2ak4 , 1qse , 1qsf , 1bd2 , 1ao7 , 2ypl , 4g8g , 4g9f , 4jrx , 4jry - hβ-2-microglobulin + hMHC I α + T cell receptor + peptide3kxf , 3mv8 , 2jcc , 2uwe - hβ-2-microglobulin + hMHC I α (mutant) + T cell receptor + peptide3sjv - hβ-2-microglobulin + hMHC I α + T cell receptor + peptide2f53 - hβ-2-microglobulin (mutant) + hMHC I α + T cell receptor + peptide1p7q , 1im9 - hβ-2-microglobulin + hMHC I α + leukocyte immunoglobulin-like receptor + peptide2dyp - hβ-2-microglobulin + hMHC I α (mutant) + leukocyte immunoglobulin-like receptor + peptide3qzw , 3dmm , 1bqh , 1akj - hβ-2-microglobulin + hMHC I α + CD8 α + peptide1im3 - hβ-2-microglobulin + hMHC I α + cytomegalovirus protein US2 + peptide3cii , 3cdg - hβ-2-microglobulin + hMHC I α + CD94 ectodomain + NKG2A/NKG2B integral membrane protein + peptide3hae , 3gjf , 3cvh , 1w72 - hβ-2-microglobulin + hMHC I α + antibody + peptide1g6r , 2ckb , 3pqy , 2z31 , 1nam , 1mwa , 1g6r , 2ckb , 2ol3 , 1kj2 , 1kj3 , 1fo0 - mβ-2-microglobulin + mMHC I + T cell receptor + peptide2oi9 , 3rgv , 3c8k - mβ-2-microglobulin + mMHC I (mutant) + T cell receptor + peptide1p1z , 1p4l , 1qo3 , 1efx - mβ-2-microglobulin + mMHC I + T cell receptor + peptide3o4l - hβ-2-microglobulin +MHC I + BSLF2/BMLF1 + T cell receptor4mnq - hβ-2-microglobulin +MHC I + telomerse reverse transcriptase + T cell receptor4eup , 4euq , 4jfd , 4jfe , 4jff , 4jfo , 4jfp , 4jfq - hβ-2-microglobulin +MHC I + JKF6 + melanoma peptide4ftv - hβ-2-microglobulin +MHC I + A6 + protein TAX-1 peptide3hg1 - hβ-2-microglobulin +MHC I + cancer/MART-1+ T cell receptor4mji , 4prp , 4qok , 4qrp , 4qrr - hβ-2-microglobulin +MHC I + peptide+ T cell receptor3gjf - hβ-2-microglobulin + hMHC I + antibody + peptide3qfj - hβ-2-microglobulin + hMHC I + A6 + peptide4e5x - hβ-2-microglobulin + hMHC I + E3 glycoprotein + peptide4hkj - hβ-2-microglobulin + hMHC I + CPXV203 protein + peptide4m8v , 3wuw , 4n8v , 4no0 - hβ-2-microglobulin + hMHC I + killer cell Igg-like receptor + peptide4l3e - hβ-2-microglobulin +MHC I + DMF5 + peptideB2M in quaternary complex with CD1
2q7y - mβ-2-microglobulin + CD1D1 + ceramide derivative + fatty acid3arb , 3ard , 3are , 3arf , 3arg , 3he6 , 3he7 , 3huj - mβ-2-microglobulin + T cell receptor NKT + CD1D1 + ceramide derivative3rug - mβ-2-microglobulin + CD1D1 + VALPHA10-Vβ8B2M in quaternary complex with other molecules
3d2u - hβ-2-microglobulin + UL18 + leukocyte immunoglobulin-like receptor + peptideproteopedia link
