GTP-binding protein: Difference between revisions

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__TOC__
__TOC__
== Function ==
== Function ==
'''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell.  They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: '''heterotrimeric G proteins'''<ref>PMID:14762218</ref> and '''small GTPases'''<ref>PMID:11152757</ref>.  The structure of small GTPase is homologous to that of the α subunit of heterotrimeric G protein.  See details on GTP-binding protein LepA in [[LepA]].
'''GTP-binding proteins''' or '''G proteins''' are transmitting signals outside the cell which cause changes within the cell.  They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: '''heterotrimeric G proteins'''<ref>PMID:14762218</ref> and '''small GTPases'''<ref>PMID:11152757</ref>.  The structure of small GTPase is homologous to that of the α subunit of heterotrimeric G protein.  See details on small GTP-binding protein LepA in [[LepA]].


<scene name='Template:GPCR3sn6/3sn6memrane/15'>An activated G protein-coupled receptor</scene> (human β-2 adrenergic receptor in blue ) in a complex with a heterotrimeric G protein (3 subunits:reddish to orange-brown) and hormone (gold) ([[3sn6]]), resolution 3.2&Aring;. The boundaries of the membrane in which the GPCR sits are represented in light green.
'''Heterotrimeric G protein or guanine nucleotide-binding protein or G protein''' (GNBP) are heterodimeric membrane proteins composed of α, β and γ subunits.  GNBP is involved in mammalian cellular signaling pathways.  GNBP α subunit binds GDP or GTP.  When bound to GTP it dissociates from the β and γ subunits, binds to adenylate cyclase which converts ATP to cAMP.  See also<br />
[[G protein-coupled receptor]]<br />
[[Beta2 adrenergic receptor-Gs protein complex]].


== Disease ==
== Disease ==
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See [[GTPase HRas]]
See [[GTPase HRas]]
*'''Heterotrimeric G protein'''
*GNBP α subunit
**[[1gia]], [[1gil]] – rGNBP + GSP – rat <br />
**[[1gfi]], [[1gdd]], [[1bof]] – rGNBP + GDP  <br />
**[[1cip]], [[1svs]] – rGNBP + GNP  <br />
**[[1git]], [[1as3]], [[1svk]], [[3d7m]], [[2zjy]], [[2zjz]], [[3ffb]], [[4n0e]] – rGNBP (mutant) + GDP  <br />
**[[1bh2]], [[3ffa]] – rGNBP (mutant) + GSP  <br />
**[[3ums]], [[3umr]] – hGNBP (mutant) + GDP - human <br />
**[[1as0]], [[4n0d]] – rGNBP (mutant) + GTPγS  <br />
**[[1as2]] – rGNBP (mutant) + GDP + Pi<br />
**[[3v00]] – rGNBP/bGNBP (mutant) + GDP  <br />
**[[2xtz]] - GNBP + GDP derivative – ''Arabidopsis thaliana'' <br />
*GNBP α subunit complex with protein
**[[1agr]] – rGNBP + GDP  + regulator of G protein signalling<br />
**[[1kjy]], [[2gtp]], [[2ik8]], [[2om2]], [[4g5q]], [[2ihb]], [[2ode]], [[2v4z]], [[3onw]] – hGNBP + GDP  + regulator of G protein signaling <br />
**[[2om2]] – hGNBP (mutant) + GDP  + regulator of G protein signaling <br />
**[[2xns]] – hGNBP + GDP  + regulator of G protein signaling peptide<br />
**[[3qi2]] – hGNBP (mutant) + GDP  + regulator of G protein signaling peptide<br />
**[[4g5o]], [[4g5r]], [[4g5s]] – hGNBP (mutant) + GDP  + G protein signaling modulator<br />
**[[1shz]] – rGNBP/mGNBP + GDP  + ρ guanine nucleotide exchange factor<br />
**[[1y3a]] – rGNBP + GDP  + Kb752 peptide<br />
**[[3qe0]] – hGNBP (mutant) + GDP  + Kb752 peptide<br />
**[[2g83]] – hGNBP + GDP  + Kb1753 peptide<br />
**[[4g5o]], [[4g5r]], [[4g5s]] – hGNBP (mutant) + GDP  + G protein signaling modulator<br />
**[[1cjk]], [[1cjt]], [[1cju]], [[1cjv]], [[1cs4]], [[1cul]] – hGNBP (mutant) + GTP derivative + adenylate cyclase<br />
**[[1u0h]] – hGNBP + GTP derivative + adenylate cyclase<br />
**[[2gvd]], [[2gvz]], [[3maa]] – bGNBP + ATP derivative + adenylate cyclase<br />
**[[3g82]] – bGNBP + ITP derivative + adenylate cyclase<br />
**[[3c14]], [[3c15]], [[3c16]] – bGNBP + PPi + adenylate cyclase<br />
**[[1tl7]] – bGNBP (mutant) + GTP derivative + adenylate cyclase<br />
**[[2rgn]] – mGNBP + RHOA exchange factor + transforming protein RHOA – mouse<br />
**[[3cx8]] – mGNBP + GTP + RHOA exchange factor <br />
**[[3c7k]] – mGNBP + GDP + regulator of G protein signaling <br />
**[[4ekc]], [[4ekd]] – mGNBP (mutant) + GDP + regulator of G protein signaling <br />
**[[3ohm]], [[4gnk]] – mGNBP + GDP + phospholipase C <br />
*GNBP β subunit
**[[2pbi]] – mGNBP + regulator of G protein signaling <br />
*GNBP β+γ subunits
**[[1omw]] – bGNBP + G protein coupled receptor kinase <br />
**[[3v5w]] – bGNBP (mutant) + G protein coupled receptor kinase <br />
**[[1xhm]] – bGNBP + peptide<br />
**[[3krw]], [[3krx]] – bGNBP + balanol + β-adrenergic receptor kinase<br />
**[[3psc]], [[3pvu]], [[3pvw]], [[4mk0]] – bGNBP + β-adrenergic receptor kinase<br />
**[[3uzs]] – bGNBP + RNA + β-adrenergic receptor kinase<br />
**[[4kfm]] – hGNBP + inward rectifier K+ channel<br />
*GNBP α+β+γ subunits
**[[1gg2]], [[1gp2]] – rGNBP (mutant) + GDP  <br />
**[[1shz]] – rGNBP/mGNBP (mutant)+ GDP  + inhibitor<br />
**[[2bcj]] – bGNBP (mutant) + G protein coupled receptor kinase <br />
**[[3sn6]] – bGNBP (mutant) + lysozyme <br />


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Revision as of 11:19, 17 March 2016

E. coli small GTP-binding protein ERA complex with GDP, TRIS and sulfate (PDB code 3ieu)

Drag the structure with the mouse to rotate

3D Structures of GTP-binding protein

Updated on 17-March-2016

See GTPase HRas

  • Heterotrimeric G protein
  • GNBP α subunit
  • GNBP α subunit complex with protein
    • 1agr – rGNBP + GDP + regulator of G protein signalling
    • 1kjy, 2gtp, 2ik8, 2om2, 4g5q, 2ihb, 2ode, 2v4z, 3onw – hGNBP + GDP + regulator of G protein signaling
    • 2om2 – hGNBP (mutant) + GDP + regulator of G protein signaling
    • 2xns – hGNBP + GDP + regulator of G protein signaling peptide
    • 3qi2 – hGNBP (mutant) + GDP + regulator of G protein signaling peptide
    • 4g5o, 4g5r, 4g5s – hGNBP (mutant) + GDP + G protein signaling modulator
    • 1shz – rGNBP/mGNBP + GDP + ρ guanine nucleotide exchange factor
    • 1y3a – rGNBP + GDP + Kb752 peptide
    • 3qe0 – hGNBP (mutant) + GDP + Kb752 peptide
    • 2g83 – hGNBP + GDP + Kb1753 peptide
    • 4g5o, 4g5r, 4g5s – hGNBP (mutant) + GDP + G protein signaling modulator
    • 1cjk, 1cjt, 1cju, 1cjv, 1cs4, 1cul – hGNBP (mutant) + GTP derivative + adenylate cyclase
    • 1u0h – hGNBP + GTP derivative + adenylate cyclase
    • 2gvd, 2gvz, 3maa – bGNBP + ATP derivative + adenylate cyclase
    • 3g82 – bGNBP + ITP derivative + adenylate cyclase
    • 3c14, 3c15, 3c16 – bGNBP + PPi + adenylate cyclase
    • 1tl7 – bGNBP (mutant) + GTP derivative + adenylate cyclase
    • 2rgn – mGNBP + RHOA exchange factor + transforming protein RHOA – mouse
    • 3cx8 – mGNBP + GTP + RHOA exchange factor
    • 3c7k – mGNBP + GDP + regulator of G protein signaling
    • 4ekc, 4ekd – mGNBP (mutant) + GDP + regulator of G protein signaling
    • 3ohm, 4gnk – mGNBP + GDP + phospholipase C
  • GNBP β subunit
    • 2pbi – mGNBP + regulator of G protein signaling
  • GNBP β+γ subunits
    • 1omw – bGNBP + G protein coupled receptor kinase
    • 3v5w – bGNBP (mutant) + G protein coupled receptor kinase
    • 1xhm – bGNBP + peptide
    • 3krw, 3krx – bGNBP + balanol + β-adrenergic receptor kinase
    • 3psc, 3pvu, 3pvw, 4mk0 – bGNBP + β-adrenergic receptor kinase
    • 3uzs – bGNBP + RNA + β-adrenergic receptor kinase
    • 4kfm – hGNBP + inward rectifier K+ channel
  • GNBP α+β+γ subunits
    • 1gg2, 1gp2 – rGNBP (mutant) + GDP
    • 1shz – rGNBP/mGNBP (mutant)+ GDP + inhibitor
    • 2bcj – bGNBP (mutant) + G protein coupled receptor kinase
    • 3sn6 – bGNBP (mutant) + lysozyme

See Also

References

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