Elongation factor

spinqualitylabelsall models Structure of EF-Tu (cyan and magenta) with EF-Ts (green and yellow) (PDB entry 1efu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Elongation factors (EF) facilitate translational elongation during the formation of peptide bonds in the ribosome. EF-selB is selenocysteine-specific EF. See SelB EF-Tu or EF 1-α (elongation factor thermo unstable) is a prokaryotic EF. EF-Tu contributes to translational accuracy. It catalyzes the addition of aminoacyl tRNA. EF-Ts or EF 1-β (elongation factor thermo stable) catalyzes the release of GDP from EF-Tu. EF-G translocates the peptidyl tRNA from the A site to the P site while moving the mRNA through the ribosome. EF-SII helps RNA polymerase II to bypass blocks to elongation. EF-ELL2 enhances polyadenylation and exon skipping with the gene encoding the immunoglobulin heavy-chain complex. EF-GreA or GreB are cleavage factors allowing the resumption of elongation. EF-NusA recruits translesion DNA polymerases to gaps encountered during translation. EF-P alters the ribosome affinity to aminoacyl-tRNA. EF-1 γ acts during the delivery of aminoacyl tRNA to the ribosome. EF-2 promotes the translocation of the nascent protein chain from the A site to the P site on the ribosome. EF-3 is a unique EF in fungi hence it provides an anti-fungal drug target. See HEAT Repeat EF Spt4, Spt5, Spt6 are conserved among eukaryotes. They modulate the chromatin structure. EF-CA150 is believed to play a role in coupling transcription and splicing. Elongin B and C complex is involved in the proteasomal degredation of target proteins. Complex EF-Tu with EF-Ts is heterotetramer, or, more exactly heterodimer of homodimers (PDB entry 1efu).

3D structures of elongation factor

Updated on 28-December-2017

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• EF-Tu
  • SelB, HEAT Repeat, 1efu, 2fx3, 1etu – EcEF – Escherichia coli
    
  • 1qzd – EcEF – Cryo EM
    
  • 3u2q – EcEF + drug
    
  • 1mj1 – EcEF + Phe-tRNA + S12 + S13 + L11 – Cryo EM
    
  • 3ep2 - EcEF + tRNA + S12 + L11 + 16SRRNA + 23SRRNA – Cryo EM
    
  • 1ttt, 1ob5 – TaEF + Phe-tRNA + GDPNP - Thermus aquaticus
    
  • 1b23 - TaEF + Cys-tRNA
    
  • 1ls2 – yEF + Phe-tRNA – yeast – Cryo EM
    
  • 3wxm – ApEF + plethora protein – Aeropyrum pernix
    
  • 4h9g, 4lbv, 4lbw, 4lby, 4lbz, 4lc0 – TtEF – Thermus thermophilus
    
  • 4j0q – EF – Pseudomonas putida
    
• EF-Tu complex with antibiotics
  • 1ob2 - yEF + Phe-tRNA + antibiotic
    
  • 4v8q - TtEF + antibiotic in 30S ribosome
    
  • 1ha3 - TtEF + antibiotic + GDP
    
  • 2c77, 2c78 - TtEF + antibiotic + GTP analog
    
  • 4v68 – TtEF + antibiotic in 70S ribosome – Cryo EM
    
  • 2bvn - EcEF + GDP
    NP + antibiotic
    
  • 1d8t, 2hcj, 2hdn, 3u6b, 3u6k, 4g5g, 5jbq – EcEF + antibiotic
• EF-Tu complex with nucleotide
  • 1efu – EcEF + GDP
    
  • 1exm – TtEF + GTP analog
    
  • 1eft – TaEF + GNP – Thermus aquaticus
    
  • 1tui – TaEF + GDP
    
  • 1d2e – bEF + GDP – bovine
    
  • 1jny, 1skq – SsEF + GDP – Sulfolobus solfataricus
    
  • 3wya – PhEF + GDP - Pyrococcus horikoshii
    
• EF-Tu complex with protein
  • 3vmf – ApEF + translation termination factor
    
  • 3wy9 – PhEF + L12
    
  • 4p3y – EcEF + thiol:disulfide interchange protein
    
  • 4zv4 – PaEF + TSE6 - Pseudomonas aeruginosa
    
• EF-Tu with EF-Ts
  • 1efu, 3agp, 3agq, 4pc1 – EcEF + EcEF-Ts
    
  • 3avt, 3avu , 3avv, 3avw, 3avx, 3avy, 3vnu , 3vnv, 4fwt – EcEF + EcEF-Ts + RNA
    
  • 3mmp – EcEF + EcEF-Ts + RNA replicase beta chain
    
  • 4q7j – EcEF + EcEF-Ts + Q beta replicase + S1
    
  • 4r71 – EcEF + EcEF-Ts + RNA polymerase β chain + S1
    
  • 4pc7 – EcEF + EcEF-Ts + antibiotic + GNP
    
  • 4pc2, 4pc3, 4pc6 – EcEF + EcEF-Ts + GDP derivative
    
  • 1aip - TtEF + TtEF-Ts - Thermus thermophilus
    
  • 1xb2 – bEF + EF-Ts - bovine
    
  • 1f60 – yEF + EF-Ts C terminal
    
  • 1g7c - yEF + EF-Ts C terminal + GDPNP
    
  • 1ije, 1ijf - yEF + EF-Ts C terminal + GDP
    
  • 2b7b - yEF + EF-Ts C terminal (mutant) + GDP
    
  • 2b7c - yEF + EF-Ts C terminal (mutant)
• EF-Tu in the ribosome
  • 3eq3, 3eq4 – EcEF in 80S ribosome – Cryo EM
    
  • 4v6l, 4v6k, 4v69 - EcEF in 30S ribosome – Cryo EM
    
  • 1zc8, 3dwu – TtEF in 70S ribosome – Cryo EM
    
  • 4v5g, 4v5l, 4v5p, 4v5q, 4v5r, 4v5s - TtEF in 70S ribosome
• EF-SII
  • 1tfi – hEF – human – NMR
    
  • 3ndq - hEF domain II
    
  • 1enw – yEF domain II – NMR
    
  • 1eo0 - yEF domain I – NMR
    
  • 2xex – SaEF – Staphylococcus aureus
    
  • 1pqv, 1y1v – yEF + RNA polymerase II
    
  • 1y1y, 3gtm – yEF + RNA polymerase II + RNA
    
  • 1wjt – mEF N terminal – mouse – NMR
    
  • 2m1h – EF PWWP domain – Trypanosoma brucei – NMR
    
• EF-ELL2
  • 2e5n – hEF N2 domain - NMR
    
• EF-G
  • 1efg, 1elo, 1ktv, 1wdt, 2dy1 – TtEF
    
  • 4m1k, 4myt, 4myu – TtEF (mutant)
    
  • 1pn6, 3izp – TtEF – Cryo EM
    
  • 1fnm, 2bm0, 2bm1 – TtEF (mutant)
    
  • 2bcw – TtEF + L11 + L7/L12
    
  • 2xex – SaEF
    
  • 3zz0, 3zzt, 3zzu – SaEF (mutant)
    
  • 2bv3 - TtEF (mutant) + GTP analog
    
  • 2j7k - TtEF (mutant) + GDP analog
    
  • 1dar, 2efg – TtEF + GDP
    
  • 1jqm, 1jqs – EcEF + L11 – Cryo EM
    
  • 4fn5 – PaEF
    
  • 5tv2 – EF – Vibrio vulnificus
    
  • 5ty0 – EF N terminal – Legionella pneumophila
    
  • 5vh6 – EF N terminal – Bacillus subtilis
    
• EF-G in the ribosome
  • 4v8u, 4v5m, 4v5n – TtEF in 70S ribosome
    
  • 4v9h, 4v9j, 4v9k, 4v9l, 4v9m, 4v90 – TtEF in 30S ribosome
    
  • 4v9o, 4v9p – EcEF in 30S ribosome
    
  • 4v9d – EcEF in 30S ribosome + antibiotics – Cryo-EM
    
  • 2om7, 4v5f – TtEF in 70S ribosome – Cryo EM
    
  • 1zn0, 2rdo, 3j0e, 4v6t, 4v9b – EcEF in 30S ribosome – Cryo-EM
    
• EF-GreA/GreB
  • 2pn0 – EF – Nitrosomonas europaea
    
  • 2p4v – EcEF-GreB
    
  • 1grj – EcEF-GreA
    
• EF-NusA
  • 1wcl, 1wcn – EcEF C terminal – NMR
    
  • 2kwp - EcEF N terminal – NMR
    
  • 2jzb – EcEF + RNA polymerase subunit α - NMR
    
• EF-P
  • 1ueb – TtEF
    
  • 4v6a – TtEF in 70S ribosome
    
  • 3oyy – PaEF
    
  • 3tre – EF – Coxiella burnetii
    
  • 3a5z – EcEF + lysyl-tRNA synthetase
    
  • 1yby – EF – Clostridium thermocellum
    
  • 5j3b – EF – Acinetobacter baumannii
    
• EF-Ts
  • 1tfe – TtEF
    
  • 1b64 – hEF guanine exchange factor domain – NMR
    
  • 2cp9 – UBA domain – NMR
    
  • 1gh8 – EF – Methanobacterium thermoautotrophicum – NMR
    
  • 2yy3 – PhEF
    
  • 2uz8 – hEF (mutant)
• EF-1
  • 4c0s – rEF α-2 – rabbit
    
  • 5dqs – hEF β+γ
    
  • 1nhy – yEF γ N terminal
  • 1pbu – hEF γ C terminal (mutant) - NMR
    
  • 2mvm, 2mvn – hEF δ-1 CAR domain – NMR
    
• EF-2
  • 1n0v – yEF
    
  • 1u2r – yEF + GDP
    
  • 1n0u, 2e1r, 2npf – yEF + antifungal drug
    
  • 1zm2, 1zm3, 1zm4, 1zm9, 3b78, 3b82, 3b8h, 2zit – yEF + exotoxin
    
  • 4v4b - hEF in 40S ribosome – Cryo EM
    
  • 4cxg, 4cxh - rEF in 40S ribosome – Cryo EM
    
  • 2p8w, 2p8x, 3dny - yEF in 80S ribosome – Cryo EM
    
  • 2p8y, 2p8z - yEF+ antifungal drug in 80S ribosome – Cryo EM
    
• EF-3
  • 2ix3 – yEF
    
  • 2iwh – yEF + ADPNP
    
  • 2iw3 – yEF + ADP
    
  • 2ix8 – yEF in 80S ribosome – Cryo EM
    
• EF-4 (lepA)
  • 2ywh, 2ywe, 2ywf, 2ywg - AalepA + nucleotide - Aquifex aeolicus
    
  • 3cb4 - EclepA
    
  • 3deg - EclepA in 70S ribosome + GMPPNP – Cryo EM
    
• EF-SelB
  • 1lva – MtEF C terminal – Moorella thermoacetica
    
  • 2v9v – MtEF winged helix domain
    
  • 1wsu, 2uwm – MtEF + RNA
    
  • 2ply – MtEF (mutant) + RNA
    
  • 4zu9 - AaEF
    
  • 4aca – MmEF – Methanococcus maripaludis
    
  • 4acb – MmEF + GTP analog
    
  • 4ac9 – MmEF + GDP
    
  • 2pjp – EcEF + RNA
    
  • 5izk, 5izl, 5izm – hEF + GDP derivative
    
• EF-Spt5
  • 2do3, 2e6z, 2e70 – hEF KOW motif – NMR
    
  • 2exu – yEF
    
  • 3h7h – hEF + hEF-Spt4
• EF-Spt6
  • 3gxw, 3gxx, 3pjp – EF SH2 domain – Candida glabrata
    
  • 3psf, 3psi – yEF core domain
    
  • 3psj, 3psk – yEF SH2 domain
    
  • 2l3t - yEF SH2 domain]] - NMR
    
  • 3oak – yEF + transcription factor IWS1
• EF-CA150
  • 2dod, 2doe, 2dof, 2e71, 2kiq, 2kis – hEF FF domain – NMR
    
  • 3hfh – hEF FF domain
    
  • 2ysi– mEF WW domain - NMR
    
• Elongin BC complex
  • 1lqb, 1lm8 – hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor 1 α
    
  • 3zrc, 3ztc, 3ztd, 3zun - hEloBC + von-Hippel Lindau disease tumor suppressor + inhibitor
    
  • 3zrf - hEloBC + von-Hippel Lindau disease tumor suppressor
    
  • 2c9w, 2izv, 2jz3 – hEloBC + suppressor of cytokine signaling
    
  • 3dcg – hEloBC + virion infectivity factor
    
  • 3zkj - hEloBC + ankyrin rep
    
  • 1vcb – hEloBC + VHL
    
  • 2fnj - mEloBC + GUSTAVUS

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