4xuu: Difference between revisions
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==The hSac2 domain from human phosphoinositide phosphatase Sac2== | ==The hSac2 domain from human phosphoinositide phosphatase Sac2== | ||
<StructureSection load='4xuu' size='340' side='right' caption='[[4xuu]], [[Resolution|resolution]] 2.62Å' scene=''> | <StructureSection load='4xuu' size='340' side='right'caption='[[4xuu]], [[Resolution|resolution]] 2.62Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUU FirstGlance]. <br> | <table><tr><td colspan='2'>[[4xuu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUU FirstGlance]. <br> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/SAC2_HUMAN SAC2_HUMAN]] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.<ref>PMID:11274189</ref> <ref>PMID:17322895</ref> | [[http://www.uniprot.org/uniprot/SAC2_HUMAN SAC2_HUMAN]] Inositol 5-phosphatase which acts on phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Hydrolyzes phosphatidylinositol 4,5-bisphosphate most effectively. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation.<ref>PMID:11274189</ref> <ref>PMID:17322895</ref> | ||
==See Also== | |||
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | |||
*[[Phosphoinositide phosphatase|Phosphoinositide phosphatase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Hsu, F]] | [[Category: Hsu, F]] | ||
[[Category: Mao, Y]] | [[Category: Mao, Y]] | ||
Revision as of 10:40, 25 December 2019
The hSac2 domain from human phosphoinositide phosphatase Sac2
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