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| == Structural highlights == | | == Structural highlights == |
| <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. | | <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. |
| </StructureSection>
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| == 3D Structures of Vinculin == | | == 3D Structures of Vinculin == |
| | [[Vinculin 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Vinculin; Domains - head 140-327; tail 878-1066
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| **[[1tr2]], [[6fuy]] – hVCL - human<br />
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| **[[3h2u]] – hVCL head domain + raver1 RRM <br />
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| **[[2ibf]], [[2hsq]], [[2gww]] - hVCL head domain + SfVCL binding sites from ''Shigella flexneri''<br />
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| **[[1ydi]] - hVCL head domain +hActinin VBS<br />
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| **[[1syq]], [[1rkc]], [[1rke]] – hVCL head domain +hTalin VBS<br />
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| **[[1qkr]] – hVCL tail domain<br />
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| **[[3h2v]] - hVCL tail domain + raver1 RRM<br />
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| **[[4pr9]] - hVCL tail domain + lipid<br />
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| **[[3jbi]] - hVCL tail domain + actin – Cryo-EM<br />
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| **[[6nr7]] - cVCL – chicken<br />
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| **[[1t01]] - cVCL head domain +mTalin VBS<br />
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| **[[3zdl]] – cVCL head domain + amyloid β precursor protein N terminal<br />
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| *Metavinculin; Domains - head 1-256; tail 959-1134
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| **[[7ktt]], [[7ktu]], [[7ktv]], [[7ktw]] – hVCL – Cryo-EM<br />
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| **[[6upw]] – hVCL + actin + ADP – Cryo-EM<br />
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| **[[6fuy]] - hVCL <br />
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| **[[3rf3]] - hVCL head domain + invasin IPAA<br />
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| **[[3s90]] - hVCL head domain + mTalin-1 peptide<br />
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| **[[4dj9]] - hVCL head domain + hTalin-1 peptide <br />
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| **[[6fq4]] - hVCL head domain + TARP peptide <br />
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| **[[3tj5]] - hVCL head domain + Sca-family protein peptide<br />
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| **[[3tj6]] - hVCL head domain + protein Ps 120 peptide<br />
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| **[[4ehp]], [[5y04]] - hVCL head domain + catenin α-1 residues 277-382<br />
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| **[[3myi]] – hVCL tail domain <br />
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| **[[5l0f]], [[5l0i]], [[5l0j]] - hVCL tail domain (mutant)<br />
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| **[[5l0c]], [[5l0d]] - hVCL tail domain + lipid<br />
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| **[[5l0g]], [[5l0h]] - hVCL tail domain (mutant) + lipid<br />
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| **[[3jbk]] – hVCL tail domain + actin – Cryo-EM<br />
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| **[[6upw]] - mVCL head domain + catenin α-1<br />
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| **[[3vf0]] – hVCL tail domain + ribonucleoprotein PTB-binding<br />
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| **[[1st6]] – cVCL<br />
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| **[[2gdc]] – cVCL head domain +SfInvasin C-terminal <br />
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| **[[1xwj]] - cVCL head domain +cTalin VBS3<br />
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| **[[1zvz]], [[1zw2]], [[1zw3]], [[1u6h]] - cVCL head domain +cTalin rod<br />
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| **[[6fq4]] – cVCL head domain + TARP-VBS1<br />
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| **[[4e17]], [[4e18]] - cVCL head domain + catenin α-1 VCL-binding domain
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| }}
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| ==References== | | ==References== |
| <references /> | | <references /> |
| | </StructureSection> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
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| *Created with the participation of [[User:Susan Craig|Susan Craig]]. | | *Created with the participation of [[User:Susan Craig|Susan Craig]]. |
