14-3-3 protein 3D structures

3D structures of 14-3-3 protein

Updated on 17-September-2025 - For a general description of the protein see 14-3-3 protein

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• 14-3-3 protein σ
  • 1yz5, 6tlg – hPRS – human
    
• 14-3-3 protein σ complex with peptide
  • 1ywt, 3iqj, 3iqu, 3lw1, 3mhr, 3p1n, 4dat, 4dau, 4fl5, 4jc3, 4jdd, 4iea, 4qli, 4y5i, 4y32, 5hf3, 5btv, 5mhc, 5moc, 5mxo, 5my9, 5myc, 5n5r, 5n5t, 5n5w, 5n75, 5ok9, 5okf, 5om0, 5oma, 5xy9, 6fau, 6fav, 6faw, 6fbb, 6fcp, 6fbw, 6fby, 6fi4, 6fi5, 6g6x, 6g8i, 6g8j, 6g8k, 6g8l, 6g8p, 6g8q, 6hhp, 6hkb, 6hkf, 6hmt, 6hmu, 6hn2, 6nv2, 6qiu, 6qdr, 6qds, 6qdt, 6qhl, 6qhm, 6qzr, 6qzs, 6r5l, 6rhc, 6rjl, 6rjq, 6rjz, 6rk8, 6rki, 6rkk, 6rkm, 6rl3, 6rl4, 6rl6, 6rm5, 6rm7, 6rp6, 6rwh, 6rwi, 6rwu, 6rx2, 6s3c, 6s40, 6s9q, 6sin, 6sio, 6sip, 6siq, 6slv, 6slw, 6slx, 6t5f, 6t5h, 6t80, 6tch, 6tjm, 6tl3, 6twz, 6w0l, 6xwd, 6y1d, 6y1j, 6y3m, 6y3o, 6y3r, 6y3s, 6y3v, 6y40, 6y44, 6y58, 6y7t, 6y8a, 6y8b, 6y8d, 6y8e, 6yia, 6yib, 6yic, 6ylu, 6yow, 6yox, 6yoy, 6yp2, 6yp3, 6yp8, 6ypl, 6ypy, 6yq2, 6yr5, 6yr6, 6yr7, 6zbt, 6zcj, 6zvb, 6zvc, 6zvd, 6zve, 7aew, 7aog, 7b13, 7b15, 7bm9, 7nfw, 7nix, 7nma, 7nmw, 7nmx, 7nn2, 7nnd, 7nne, 7np2, 7npb, 7npg, 7o07, 7o6o, 7ob5, 7obc, 7obg, 7obk, 7obs, 7obx, 7qik, 7qip, 7zit, 7zmu, 7zmw, 8anb, 8bfc, 8bi7, 8bx0, 8bx3, 8bx4, 8by9, 8byf, 8c04, 8c0k, 8c28, 8c2d, 8c2e, 8c2y, 8c3z, 8c40, 8p0d – hPRS + peptide
    
  • 3p1p, 3p1r, 5lu1, 5lu2 – hPRS (mutant) + peptide
    
  • 5ltw – hPRS (mutant) + HSPB6
    
  • 3iqv, 3o8i, 3p1o, 3ux0, 4fr3, 6ghp, 6rws, 6s39, 6y3w, 6xxc, 6xy5, 6y18, 6y3a, 7axn, 7ayf, 7az1, 7az2, 7b9m, 7b9r, 7b9t, 7ba3, 7ba5, 7ba6, 7ba7, 7ba8, 7ba9, 7baa, 7bab, 7bdp, 7bdt, 7bdy, 7bfw, 7bg3, 7bgq, 7bgr, 7bgv, 7bgw, 7bi3, 7biq, 7biw, 7biy, ]]7bjb]], 7bjf, 7bjl, 7bjw, 7bkh, 7bmc, 7nif, 7nig, 7niz, 7nj6, 7nj8, 7nj9, 7nja, 7njb, 7nk3, 7nk5, 7nle, 7nm3, 7nqp, 7nrk, 7nrl, 7nla, 7nm1, 7nm9, 7nmh, 7nr7, 7nsv, 7nv4, 7nvi, 7nws, 7nxs, 7nxt, 7nxw, 7nxy, 7ny4, 7nyf, 7nz6, 7nzg, 7nye, 7nyg, 7nzk, 7nzv, 7o34, 7o3a, 7o3f, 7o3p, 7o3q, 7o3r, 7o3s, 7o57, 7o59, 7o5a, 7o5c, 7o5d, 7o5f, 7o5g, 7o5o, 7o5p, 7o5s, 7o5u, 7o5x, 7o6f, 7o6g, 7o6i, 7o6j, 7o6k, 7o6m, 7ob8, 7obd, 7obh, 7obl, 7obt, 7oby, 7opw, 7oq7, 7oq8, 7oq9, 7oqa, 7oqg, 7oqj, 7oqs, 7oqu, 7oqw, 7or3, 7or5, 7or7, 7or8, 7org, 7orh, 7ors, 7ort, 7pwt, 7pwz, 8a62, 8a65, 8a68, 8a6f, 8a6h, 8adm, 8afn, 8ai0, 8alr, 8alt, 8alv, 8alw, [[[8am7|8am7]], [8anc]], 8anf, 8aoy, 8aps, 8ar4, 8ar5, 8arg, 8aro, 8arq, 8arr, 8arw, 8arx, 8ary, 8arz, 8aq1, 8aqc, 8aqe, 8aqz, 8as1, 8at9, 8atp, 8atr, 8ats, 8au2, 8aus, 8auy, 8av0, 8av3, 8av4, 8av7, 8av8, 8awg, 8axe, 8axu, 8aze, 8b2i, 8b2k, 8b39, 8b4q, 8b5p, 8bjg, 8bjn, 8bm5, 8btq, 8bwe, 8bwh, 8bwj, 8bwx, 8bwz, 8bxi, 8bxm, 8bxn, 8bxq, 8bxs, 8byb, 8byc, 8byd, 8bye, 8byg, 8byo, 8byy, 8byz, 8bz9, 8bz0, 8bza, 8bzb, 8bzc, 8bzd, 8bze, 8bzf, 8bzg, 8bzh, 8bzt, 8bzw, 8c0l, 8c1y, 8c2g, 8c30, 8c3c, 8c42, 8c43, 8c4f, 8c4g – hPRS + peptide + stabilizer
    
  • 3p1q, 3p1s, 3spr, 3smk, 3sml, 3smm, 3smn, 3smo, 3sp5 – hPRS (mutant) + peptide + stabilizer
    
• 14-3-3 protein σ binary complex with small molecule
  • 3u9x, 6tm7 – hPRS + pyridoxal phosphate
    
  • 3t0l, 3t0m, 4dhm, 4dhn, 4dho, 4dhp, 4dhq, 4dhr, 4dhs, 4dht, 4dhu, 6ye9 – hPRS + inhibitor
    
  • 5oeh, 5oeg – hPRS + molecular tweezers
    
  • 6tlf – hPRS + IMP
    
  • 6qdu – hPRS + phosphothreonine
    
• 14-3-3 protein σ binary complex with protein
  • 8q4l – hPRS + GBP1 – Cryo EM
    
• 14-3-3 protein ζ
  • 6uan – hPRS + Raf peptide – Cryo EM
    
  • 8chf, 8cpd – hPRS + CRaf – Cryo EM
    
  • 9axa – hPRS + CRaf + MEK + peptide – Cryo EM
    
  • 4wrq, 4zdr, 6f08, 6f09, 6ymo, 6yo8, 6yos, 7d8h, 8ah2 – hPRS + peptide
    
  • 6zfd – hPRS/protein E6
    
  • 6zfg – hPRS/protein E6 + stabilizer
    
  • 7q16 – hPRS/BAD peptide
    
  • 8a9g – hPRS + peptide + stabilizer
    
  • 1a4o – bPRS - bovine
    
  • 1a37, 1a38 – bPRS + peptide
    
  • 7exe – mPRS + ADAM22 peptide - mouse
    
  • 6nyb, 6q0j, 6q0t – baPRS + B-Raf + MKK1 – beet armyworm – Cryo EM
    
  • 8dgs, 8dgt – baPRS + B-Raf + MKK1 + Kras – Cryo EM
    
• 14-3-3 protein ζ/δ
  • 3rdh – hPRS
    
  • 3rdh – hPRS/LKB1
    
  • 1qja, 1qjb, 2c1j, 2c1n, 2o02, 2v7d, 2wh0, 3cu8, 3nkx, 4bg6, 4fj3, 4hkc, 4ihl, 4n7g, 4n7y, 4n84, 5d2d, 5ewz, 5exa, 5j31, 5jm4, 5m35, 5m36, 5m37, 5nas, 5ulo, 5wxn, 6f5, 6ejl, 6eww, 6f08, 6rlz, 7d8p, 7d9v, 7dh8 – hPRS + peptide
    
  • 5d3f – hPRS + CFTR peptide + stabilizer
    
  • 6u2h, 6xag – hPRS + B-Raf
    
  • 6q0k, 7mfe – hPRS + B-Raf – Cryo EM
    
  • 7mff – hPRS + B-Raf + inhibitor – Cryo EM
    
  • 7mfd – hPRS + B-Raf + MEK – Cryo EM
    
  • 1ib1 – hPRS + serotonin N-acetyltransferase
    
  • 6fn9, 6fna, 6fnb, 6fnc – hPRS + inhibitor
    
• 14-3-3 protein β
  • 8eq8 – hPRS
    
  • 7qi1 – hPRS + CFTR peptide + stabilizer
    
• 14-3-3 protein β/α
  • 2bq0, 4dnk, 8eqh – hPRS
    
  • 2c23, 5n10, 6a5q, 6byk, 6gn0, 6gn8, 6gnj, 6gnk, 6gnn, 6hep – hPRS + peptide
    
  • 6ygj – hPRS + ChREBP peptide + stabilizer
    
  • 4gnt – mPRS + ChREBP peptide
    
  • 5f74 – mPRS + ChREBP + AMP
    
  • 5wfu, 5wfx – mPRS + malate
    
• 14-3-3 protein β/α + 14-3-3 protein epsilon
  • 8dp5 – hPRS + PEAK3 + peptide – Cryo EM
    
• 14-3-3 protein γ
  • 4e2e – hPRS
    
  • 2b05, 3uzd, 4j6s, 4o46, 5d3e, 6a5q, 6a5s, 6byj, 6byl, 6fel, 6gkf, 6gkg, 6s9k, 6sad, 6zc9, 7a6r, 7a6y – hPRS + peptide
    
  • 6bzd – hPRS (mutant) + O-GlcNAc peptide
    
  • 6y4k, 6y6b – hPRS + CaMKK 2 peptide + stabilizer
    
• 14-3-3 protein delta
  • 8c2f – hPRS + peptide
    
• 14-3-3 protein ε
  • 2br9, 6eih, 8dgm, 8dgn, 8dgp, 8q1s – hPRS + phosphopeptide
    
  • 3ual, 3ubw – hPRS + myeloid leukemia factor 1 peptide
    
  • 7c8e – hPRS + 9J10 peptide
    
• 14-3-3 protein θ
  • 5iqp – hPRS
    
  • 2btp, 6kzg, 6kzh – hPRS + phosphopeptide
    
  • 6bcr, 6bcy, 6bd1, 6bd2, 6bqt – hPRS + IRSp53 peptide
    
• 14-3-3 protein η
  • 2c63, 2c74 – hPRS + phosphopeptide
    
  • 5yqg – hPRS + NUMB peptide
    
  • 7nmz – hPRS + E3 ubiquitin-protein ligase NEDD4-like
    
• 14-3-3 protein
  • 2npm, 3efz – PRS + phosphoserine – Cryptosporidium parvum
    
  • 4f7r, 5by9 – GiPRS – Giardia intestinalis
    
  • 4zq0 – GiPRS + phosphoserine
    
  • 8hew – PRS + peptide – potato
    
  • 6qk8 – PRS + peptide – yeast
    
• 14-3-3-like protein C
  • 1o9c, 1o9e – tPRS - tobacco
    
  • 1o9d, 1o9f, 2o98, 3e6y – tPRS + H+ ATPase peptide
    
  • 5nwi, 5nwj, 5nwk – tPRS + potassium channel peptide
    
  • 3m50, 3m51 – tPRS + PMA2 peptide + stabilizer
    
• 14-3-3-like protein GF14-C
  • 3axy – PRS + HD3A + OSFD1 - rice
    
• 14-3-3-like protein E
  • 4dx0 – tPRS + PMA2 peptide + stabilizer
    

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