Severin

File:3fg6.png

3D Structure of Severin
The image at the top is a human Severin (3fg6)

Actin Binding Protein

Severin is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins. Severin comprises 6 homologous domains (A1-A6), which share 60% identity with the 6 domains from Gelsolin (G1-G6). It is named Adseverin and Scinderin as well. The image at the right is an octamer (each monomer is colored in different color) of the Severin with calcium ions (colored lime).

3D Structures of Severin

3fg6 – Adseverin C-terminal – human
1svy – Severin domain 2 – Dictyostelium discoideum
1svq - Severin domain 2 - Dictyostelium discoideum, NMR

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel