Albumin
ContentsFunctionAlbumin (Alb) is water-soluble protein. Serum albumin (SA) is the most abundant blood plasma protein. SA serves as carrier of fatty acids, bilirubin, ions and drugs. For details on human serum albumin see
Investigation on the Site-Selective Binding of Bovine Serum Albumin by Erlotinib Hydrochloride [1]The binding mode of erlotinib hydrochloride (ET), a targeted anticancer drug, to bovine serum albumin (BSA) was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (red for subdomain IA; orange, IB; cyan, IIA; yellow, IIB; green, IIIA; darkmagenta, IIIB). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the binding site was located in the hydrophobic pocket of site I (subdomain IIA). The docking modeling agreed with the results of the fluorescence and displacement experiments.
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3D Structures of albumin
Updated on 03-March-2019
- Human serum albumin
- 1e78, Molecular Playground/Human Serum Albumin, STRUCTURE 1BM0, Albumin (Hebrew), 3sqj, 4g03, 4g04, 4k2c - hSA – human
- Human serum albumin binary complex
- 2ydf – hSA + iophenoxic acid
- 2xvq, 2xvu, 2xw0, 2xw1 - hSA + dansyl derivative
- 3lu6, 3ju7, 3lu8, 2bx8, 2bxa, 2bxb, 2bxc, 2bxd, 2bxe, 2bxf, 2bxg, 2bxh, 2bxi, 2bxk, 2bxl, 2bxm, 2bxn,2bxo, 2bxp, 2bxq, 3lu7, 4l8u, 4l9k, 4l9q, 4la0, 4lb2, 4lb9, 5ifo, 5id9, 5id7, 5gix, 5giy – hSA + drug
- 4iw1, 4iw2 – hSA + monosaccharide
- 3jqz – hSA + lidocaine
- 3jry - hSA + sulfate
- 4emx – hSA + Cl
- 5ifj, 5ije, 5ij5, 5iix, 5iiu, 5iih – hSA + Zn
- 4s1y – hSA + cisplatin
- 1n5u - hSA + heme
- 3a73 - hSA + prostaglandin
- 2vuf, 2vue - hSA + bilirubin derivative
- 5ujb – hSA + MCL-1 inhibitor
- 5yoq – hSA + phenylbutyrate
- 1gni, 1gnj, 1e7h, 1e7e, 1e7f, 1e7i, 1bke, 1bj5, 3tdl, 4e99, 4bke, 6ezq - hSA + fatty acid
- 1hk1 - hSA + thiroxine
- 2hk2, 1hk3, 1hk2 - hSA (mutant) + thiroxine
- 1e7a, 1e7b - hSA + general anesthetic
- 1tf0 - hSA + peptostreptococcal albumin-binding protein GA module
- 2esg - hSA + immunoglobulin A1
- 1ysx - hSA + anti-apoptotic ligand – NMR
- 4hgk, 4hgm, 5fuo – hSA + shark antibody
- 5vnw – hSA + nanobody
- 2ydf – hSA + iophenoxic acid
- Human serum albumin ternary complex
- 2xsi, 2xvv, 2xvw – hSA + dansyl derivative + myristic acid
- 3cx9 - hSA + lysophospholipid + myristic acid
- 1e7g - hSA + fatty acid + myristic acid
- 1h9z, 1ha2 - hSA + warfarine + myristic acid
- 1e7c - hSA + general anesthetic + myristic acid
- 1hk4 - hSA + thiroxine + myristic acid
- 1hk5 - hSA (mutant) + thiroxine + myristic acid
- 1o9x - hSA + hemin + myristic acid
- 3uiv - hSA + amantadine + myristic acid
- 3b9l - hSA + AZT + myristic acid
- 2i2z - hSA + aspirin + myristic acid
- 2i30 - hSA + salicylic acid + myristic acid
- 4z69 – hSA + palmitate + diclofenac
- 5x52 – hSA + octanoate + acetyl methionine
- 3b9m - hSA + AZT + salicylic acid + myristic acid
- 2vdb - hSA + peptostreptococcal albumin-binding protein GA module + naproxen
- 4k71, 4n0f – hSA + Igg receptor + β-2-microglobulin
- 4n0u – hSA + Igg receptor + β-2-microglobulin + Ig γ-1 chain C
- 2xsi, 2xvv, 2xvw – hSA + dansyl derivative + myristic acid
- Other serum albumins
- 3v03, 4f5s - bSA – bovine
- 3v08, 4f5t, 4f5u, 5hoz – hoSA – horse
- 3v09, 4f5v – rSA – rabbit
- 4luf, 5orf – sSA – sheep
- 5ori, 5otb – gSA – goat
- 3vvj – SA – emu
- 5ghk – SA – dog
- 4j2v – hoSA + diiodosalicilate
- 4jk4 – bSA + diiodosalicilate
- 4luh – sSA + diiodosalicilate
- 5osw – gSA + diiodosalicilate
- 4or0 – bSA + drug
- 4ot2, 5dqf, 5dby, 4zbr, 4zbq, 5v0v, 6ci6 – hoSA + drug
- 4po0 – rSA + drug
- 3v03, 4f5s - bSA – bovine
- Albumin
References