Aminotransferase 3D structures

3D structures of aminotransferase

Updated on 14-March-2019

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• Histidinol-phosphate aminotransferase
  • 1gew, 1iji – EcHPA + PLP – Escherichia coli
    
  • 1gey, 1fg7 – EcHPA + PLP derivative
    
  • 1gex, 1fg3 – EcHPA + PLP + histidinol-phosphate
    
  • 1uu0 – TmHPA + phosphate – Thermotoga maritima
    
  • 1uu1 – TmHPA + PLP derivative + histidinol-phosphate
    
  • 1h1c – TmHPA + PLP
    
  • 1uu2, 2f8j – TmHPA + PLP derivative
    
  • 3cq4 – CgHPA – Corynebacterium glutamicum
    
  • 3cq5, 3cq6 – CgHPA + PLP derivative
    
  • 3ffh – HPA – Listeria innocua
    
  • 3ftb – HPA + phosphate – Clostridium acetobutylicum
    
  • 3hdo – HPA – Geobacter metallireducens
    
  • 4rae – MtHPA – Mycobacterium tuberculosis
    
  • 4r8d, 5c6u, 5yhv – MtHPA + PLP
    
• Ornithine aminotransferase
  • 1oat – hOA + PLP – human
    
  • 1gbn, 2can – hOA + PLP + inhibitor
    
  • 2oat – hOA + PLP derivative
    
  • 2byj, 2byl – hOA (mutant) + PLP
    
  • 5eav – TgOA – Toxoplasma gondii
    
  • 5eqc, 4zwm – TgOA + PLP
    
  • 5e5i – TgOA + inactivator
    
  • 5e3k – TgOA + pentanoic acid derivative
    
  • 5dj9 – TgOA + gabaculine
    
• Acetylornithine aminotransferase
  • 2ord, 2e54 – TmACOAT + PLP
    
  • 2eh6 – ACOAT + PLP – Aquifex aeolicus
    
  • 3nx3 – CjACOAT – Campylobacter jejuni
    
  • 5viu – ACOAT – Elizabethkingia anophelis
    
  • 4jev – StACOAT + PLP derivative – Salmonella typhimurium
    
  • 4jey – StACOAT (mutant) + PLP
    
  • 4jf0, 4f01 – StACOAT (mutant) + PLP derivative
    
  • 4jew, 4jex, 4jez – StACOAT (mutant) + canaline
    
• Succinylornithine aminotransferase
  • 4ade – EcSOAT
    
  • 4adb, 4adc – EcSOAT + PLP
    
  • 4add – EcSOAT + PLP + succinylornithine
    
• Aspartate Aminotransferase
• Phosphoserine aminotransferase
• Alanine glyoxylate aminotransferase
  • 1h0c, 2yob, 5f9s, 5og0 – hAGA + PLP
    
  • 4cbr, 4cbs, 5ofy, 5luc – hAGA (mutant) + PLP
    
  • 1j04, 5hhy – hAGA + PLP derivative
    
  • 4i8a – hAGA (mutant) + PLP derivative
    
  • 3r9a – hAGA + PLP derivative + peroxisomal targeting signal receptor
    
  • 4kxk, 4kyo – hAGA (mutant) + peroxisomal targeting signal receptor
    
  • 1vjo – AGA + PLP - Nostoc
    
  • 2huf – AaAGA + PLP derivative – Aedes aegypti
    
  • 2hui – AaAGA + PLP derivative + glyoxylate
    
  • 2huu – AaAGA + PLP derivative + alanine
    
• D-amino acid aminotransferase
  • 1a0g - BaAAT + PLP derivative – Bacillus
    
  • 1daa, 4daa - BaAAT + PLP
    
  • 2dab, 1g2w - BaAAT (mutant) + PLP
    
  • 2daa, 3daa - BaAAT + PLP derivative
    
  • 5daa - BaAAT (mutant) + PLP derivative
    
  • 3lqs - BaAAT + thiophenecarboxylic acid
    
  • 4m0j - BtAAT – Burkholderia thailandensis
    
  • 4tm5 - BtAAT + PLP
    
• Branched chain amino acid aminotransferase
  • 1ekf, 1ekp, 1ekv – hBCAT + PLP
    
  • 2hdk, 2hgw, 2hgx, 2hhf, 5mpr – hBCAT (mutant) + PLP
    
  • 1kt8, 1kta – hBCAT + PLP derivative
    
  • 2alh, 5bwr, 5bwt, 5bwu, 5bwv, 5bwx, 5bww, 5cr5 – hBCAT + PLP + inhibitor
    
  • 5i60, 5i5y, 5i5x, 5i5w, 5i5v, 5i5u, 5i5t, 5i5s, 5hne – hBCAT + PLP + biaryl amide
    
  • 2hg8 – hBCAT (mutant) + PLP + methylleucine
    
  • 4chi – AfBCAT + PLP – Aspergillus fumigatus
    
  • 4uug – AfBCAT + inhibitor
    
  • 4cmd – NhBCAT + PLP – Nectria haematococca
    
  • 4cmf – NhBCAT + inhibitor
    
  • 5cm0 – GaBCAT + PLP – Geoglobus acetivorans
    
  • 5e25 – GaBCAT + PLP + ketoglutarate
    
  • 5ce8 – BCAT + PLP – Thermoproteus uzoniensis
    
  • 5u3f – MtBCAT + cycloserine
    
  • 6nst - BCAT – Pseudomonas aeruginosa
    
  • 6gkr – TteBCAT + PLP – Thermobaculum terrenum
    
  • 6q8e – TteBCAT + PLP derivative
    
  • 6h65 – TteBCAT + PLP – Haliangium ochraceum
    
  • 4whx – BCAT + PLP – Burkholderia pseudomallei
    
• Aromatic amino acid aminotransferase
  • 1ay4 – PdAROAT + PLP – Paracoccus dentrificans
    
  • 1ay5 – PdAROAT + PLP + maleic acid
    
  • 1ay8, 1ay1 – PdAROAT + PLP + cinnamic acid derivative
    
  • 2ay2, 2ay3, 2ay4, 2ay5 – PdAROAT + PLP + propionic acid derivative
    
  • 2ay6, 2ay7, 2ay8 – PdAROAT + PLP + butyric acid derivative
    
  • 2ay9 – PdAROAT + PLP + valeric acid derivative
    
  • 4eff – BpAROAT – Burkholderia pseudomallei
    
  • 4f4e – BpAROAT + PLP derivative
    
  • 4rkc – PsAROAT + PLP derivative - Psychrobacter
    
  • 4rkd – PsAROAT + PLP derivative + PLP
    
  • 6hnb – CaAROAT – Candida albicans
    
  • 6hnu – CaAROAT + PLP + Phe
    
• Tyrosine aminotransferase
  • 3dyd – hTYRAT + PLP
    
  • 3pdx – mTYRAT + PLP derivative – mouse
    
  • 3tat – EcTYRAT + PLP
    
  • 3fsl – EcTYRAT (mutant) + PLP derivative
    
  • 1bw0 – TYRAT + PLP derivative – Trypanosoma cruzi
    
  • 4ix8 – TYRAT + PLP derivative – Leishmania infantum
    
• Tryptophan aminotransferase
  • 3bwn, 3bwo – TRYAT + PLP derivative – Arabidopsis thaliana
    
• Beta-phenylalanine aminotransferase
  • 4ao9 – VpPHEAT + PLP – Variovorax paradoxus
    
  • 4aoa – VpPHEAT + PLP derivative
    
• Alanine aminotransferase
  • 3ihj – hALAAT 2 + PLP
    
  • 3tcm – ALAAT 2 (mutant) + PLP derivative - barley
    
• Cysteine aminotransferase
  • 4w91 – CYSAT + PLP – Brucella suis
    
• Glutamine aminotransferase
  • 1v2d – TtGLNAT + PLP – Thermus thermophilus
    
  • 1v2e – TtGLNAT + PLP + keto-methylthiobutyrate
    
  • 1v2f – TtGLNAT + PLP + phenylpropionate
    
• Lysine aminotransferase
  • 2cin – MtLYSAT + PLP
    
  • 2jje – MtLYSAT (mutant) + PLP
    
  • 2jjf – MtLYSAT (mutant)
    
  • 2cjd – MtLYSAT + PLP + lysine
    
  • 2jjg – MtLYSAT + PLP + inhibitor
    
  • 2cjg – MtLYSAT + PLP derivative
    
  • 2cjh – MtLYSAT + PLP + oxoglutarate
    
  • 2jjh – MtLYSAT (mutant) + PLP + oxoglutarate
    
• Gamma-aminobutyrate aminotransferase
  • 1sf2 – EcGABA + PLP
    
  • 1sff – EcGABA + PLP derivative
    
  • 1szk, 1szs, 1szu – EcGABA (mutant) + PLP derivative
    
  • 3r4t – GABA + PLP derivative – Mycobacterium marinum
    
  • 4ffc – GABA + PLP derivative – Mycobacterium abscessus
    
  • 4zsy, 4zsw, 4y0i, 4y0h, 4y0d, 6b6g – GABA + inactivator - pig
    
• ArnB aminotransferase
  • 1mdo - StArnB + PLP derivative
    
  • 1mdx – StArnB + PLP + oxoglutarate
    
  • 1mdz – StArnB + PLP + PLP derivative
    
• PseC aminotransferase
  • 2fni - HpPseC + PLP – Helicobacter pylori
    
  • 2fn6 - HpPseC + phosphate
    
  • 2fnu - HpPseC + PLP derivative + uridine derivative
    
  • 3hbm - CjPseC (mutant)
    
  • 3hbn - CjPseC (mutant) + UDP
    
• TlmJ aminotransferase
  • 5uid - TlmJ + PLP – Streptoalloteichus hindustanus
    
• WbpE aminotransferase
  • 3nu7, 3nu8, 3nub, 3nyu - PaWbpE + PLP derivative
    
  • 3nys - PaWbpE (mutant) + PLP
    
  • 3nyt - PaWbpE (mutant) + PLP derivative
    
• Alpha-aminoadipate aminotransferase
  • 2egy, 5eun - TtAADAT + PLP
    
  • 3cbf, 2zyj - TtAADAT + PLP derivative
    
  • 2zp7, 2z1y - TtAADAT + PLP + leucine
    
  • 4je5 - AADAT + PLP derivative + PLP - yeast
    
• Broad specificity aminotransferase
  • 4wb0 - BsAT – Leishmania mexicana
    
• Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
  • 4w1x, 4w1w, 4w1v, 4xjl, 4xjm, 4xjo, 4xjp, 4wya, 4wyc, 4wyd, 4wye, 4wyf, 4wyg, 4xew - MtDAPA + PLP + inhibitor
    
  • 4mqr, 4mqq, 4mqp - MtDAPA + inhibitor
    
  • 5uc7 - DAPA + PLP derivative – Citrobacter rodentium
    
  • 5te2 - MbDAPA + inhibitor – Mycobacterium bovis
    
  • 5kgs, 5kgt - MbDAPA + PLP + inhibitor
    
• Putrescine aminotransferase
  • 4uoy - EcPAT + PLP
    
  • 4uox - EcPAT + PLP + putrescine
    
• Omega amino acid-pyruvate aminotransferase
  • 4uho, 4uhn, 4uhm - PaOAAT + PLP
    
• C-6’ aminotransferase
  • 6cbo - MeAT – Micromonospora echinospora
    
  • 5z83 – MeAT + PLP
    
  • 5z8a – MeAT + PLP + JI-20A
    
  • 5z8k – MeAT + PLP + neomycin
    
• Kynurenine aminotransferase
  • 4wlh, 4wlj, 4wp0 – hKAT 1 + PLP derivative
    
  • 5efs, 6d0a – hKAT 2
    
  • 5tf5 – hKAT 2 + PLP derivative + inhibitor
    
  • 5vep, 5veq, 5ver – mKAT 3 + PLP derivative
    
  • 5veh – AaKAT + PLP derivative
    
• Diaminopelargonic acid aminotransferase
  • 6erk – DPAAT + PLP – Psychrobacter cryohalolentis
    
• D-phenylglycine aminotransferase
  • 6dvs – DPGAT – Pseudomonas stutzeri
    
• Aminotransferase class II
  • 5z0q – AT2 + PLP – Erwinia tasmaniensis
    
• Aminotransferase class III
  • 5ghg, 5ghf – AT3 + PLP derivative – Orchrobactrum anthropi
    
  • 5m46 – RfAT3 + PLP – Rhizobium freirei
    
  • 5m49 – RfAT3 + PLP + azepan derivative
    
  • 5m4b, 5m4d – RfAT3 (mutant) + azepan derivative
    
  • 5d95 – AT3 + PLP derivative – Sphaerobacter thermophilus
    
• Aminotransferase class IV
  • 4tvi – AT4 + PLP derivative – Brucella abortus
    

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Michal Harel, Joel L. Sussman