Talin

spinqualitylabelsall models Talin rod domain residues 1359-1659 (PDB code 2x0c) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Talin is involved in cell-cell contacts. It links integrins to actin. It contains a C-terminal rod domain with integrin binding sites (IBS) and actin binding sites (ABS) and N-terminal FERM domain with subdomains F1-F3. The F3 subdomain interacts with integrin. Talin contains 3 Vinculin binding sites VBS1-VBS3.

3D Structures of Talin

Updated on 19-November-2020

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• Talin mouse subdomains: F1 1-85; F2 86-202; F3 203-405; VBS1 482-655; R4 913-1044; B 1046-1207; C 1207-1357; R7-R8 1359-1659; rod 1359-2293; dimerization 2494-2541
  • Vinculin – hTal-1 – human – Cryo EM
    
  • 6u4k – hTal-2 F1-F3
    
  • 2kc1, 6ba6 - mTal F1 domain – mouse - NMR
    
  • 2kc2 - mTal F2 domain – NMR
    
  • 2kma – mTal F1F2 domain – NMR
    
  • 3ivf – mTal FERM domain F1F2F3
    
  • 4f7g - mTal F2F3 domain + rod segment domain residues 1654-1847
    
  • 2kgx – mTal F3 domain + rod fragment residues 1655-1822 – NMR
    
  • 1sj7, 1sj8 - mTal VBS1 domain
    
  • 5nl1 - mTal VBS1 domain + IPAA
    
  • 2lqg - mTal R4 helix domain – NMR
    
  • 2l7n – mTal B domain – NMR
    
  • 2l10 – mTal C domain – NMR
    
  • 2x0c – mTal rod residues 1359-1659
    
  • 5ic0, 2kbb – mTal triple domain residues 1357-1822
    
  • 5ic1 – mTal triple domain residues 1357-1822 (mutant)
    
  • 4w8p - mTal R7-8 + RIAM
    
  • 5fzt - mTal R7-8 + Rho GTPase activating protein 7 peptide
    
  • 3dyj - mTal rod residues 1974-2293
    
  • 2qdq – mTal dimerization domain
    
  • 2mwn – hTal1 residues 308-400 + RIAM – human - NMR
    
  • 2hrj - cTal F2 – chicken - NMR
    
  • 1mix – cTal F2F3 residues 196-400
    
• Talin integrin-binding sites
  • 2jsw, 2qdq – mTal IBS – NMR
    
  • 3g9w – mTal2 F2F3+integrin tail
    
  • 1miz, 1mk7, 1mk9 - cTal F2F3 residues 200-400 +integrin tail
    
  • 2h7d, 2h7e - cTal FERM F3+integrlin fragment – NMR
    
  • 3fyq – Tal rod IBS2 residues 1981-2168 – Drosophila melanogaster
• Talin vinculin-binding sites
  • 2kvp, 2b0h – mTal VBS3 residues 2300-2482 – NMR
    
  • 1xwj, 1zvz, 1zw2, 1zw3 - cTal VBS3+ vinculin head – chicken
    
  • 1u6h - cTal VBS2 residues 849-879 + vinculin head
    
  • 1t01 - meal VBS1 residues 605-628 + vinculin head
    
  • 1syq - hTal VBS1+ vinculin head
    
  • 1rkc - cTal VBS3+ vinculin head
    
  • 3s90 - mTal VBS3 residues 1512-1546 + vinculin head
    
  • 1u89, 2l7a - mTal VBS2 – NMR
    
  • 4dj9 – hTal VBS50 + vinculin head
• Talin phosphatidylinositol phosphate kinase binding sites
  • 1y19 - mTal F2F3+ PIP kinase C-terminal
    
  • 6mfs - mTal F2F3+ PIP
    
  • 2g35 - mTal F3+PIP kinase peptide – NMR
• Talin layilin-binding sites
  • 2k00 - cTal F3+layilin fragment – NMR

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Alexander Berchansky, Joel L. Sussman, Michal Harel