Pre-mRNA splicing factors 3D structures

3D Structures of pre-mRNA splicing factors

Updated on 31-January-2022

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• Pre-mRNA-splicing factor 2
  • 3beg – hPrp P33 subunit + Ser/Thr-protein kinase – human
    
  • 2o3d – hPrp P33 subunit
    
  • 7dcq – yPrp – yeast – Cryo EM
    
  • 7dcr – yPrp + Prp spp2 – Cryo EM
    
  • 7dd3 – yPrp + Prp spp2 + RNA – Cryo EM
    
  • 7dcp – yPrp + Prp spp2 + ADP – Cryo EM
    
• Pre-mRNA-splicing factor 3
  • 1x4q – hPrp PWI domain - NMR
    
  • 4yhu, 4yhv – yPrp C-terminal
    
  • 4yhw – yPrp C-terminal + snRNA
    
• Pre-mRNA-splicing factor 3B
  • 3lqv, 2f9d, 2f9j – hPrp residues 377-415 + pre-mRNA branch site protein 14
    
  • 2fho - hPrp residues 379-424 + spliceosomal protein P14 - NMR
    
  • 2do5 – hPrp subunit 2 – NMR
    
  • 1x5t - hPrp subunit 4 – NMR
    
  • 5gvq - hPrp subunit 4 RNA-binding domain – NMR
    
  • 6en4 - hPrp subunits 1,3,5 + SF3B14B
    
  • 5ife - hPrp subunits 1,3,5 + PHD finger-like protein 5A
    
  • 5zya - hPrp subunits 1,3,5 + PHD finger-like protein 5A + splicing modulator
    
• Pre-mRNA-splicing factor 8
  • 3e9l, 3enb, 3lru – hPrp endonuclease domain 1769-1990
    
  • 6s8q, 6s9i – hPrp residues 2064-2320 + U5 small nuclear ribonudleoprotein
    
  • 2p8r – CePrp C terminal (mutant) – Caenorhabditis elegans
    
  • 2p87 – CePrp C terminal
    
  • 6nqi – Prp RH domain – red alga
    
  • 6teo – yPrp residues 315-555 + yPro SNU114
    
  • 3sbt, 4ilh – yPrp RNAse H like domain 1835-2096 + A1 cistron-splicing factor AAR2
    
  • 4jk7, 4jk9, 3e9o, 3e9p, 3e66 - yPrp RNAse H like domain
    
  • 4ilj, 4jk8, 4jka, 4jkb, 4jkc, 4jkd, 4jke, 4jkf, 4jkg, 4jkh - yPrp RNAse H like domain (mutant)
    
  • 3zef, 4i43 – yPrp + A1 cistron-splicing factor AAR2
    
  • 2og4, 3sbg - yPrp Jab1/MPN domain
    
  • 4bgd, 5dca, 5m52, 5m5p – yPrp Jab1/MPN domain + pre-mRNA-splicing helicase BRR2
    
  • 4kit – yPrp Jab1/MPN domain + U5 small nuclear ribonucleoprotein helicase
    
  • 4ilg – yPrp Jab1/MPN+RNA-binding domains + A1 cistron-splicing factor AAR2
    
  • 6mwy, 6myl – Prp – Cryptococcus gattii
    
  • 6mx6 – Prp – Cryptococcus neoformans
    
• Pre-mRNA-splicing factor 9
  • 4dgw – yPrp + Prp 21 + Prp 11
• Pre-mRNA-splicing factor 11
  • 4dgw – yPrp + Prp 21 + Prp 9
• Pre-mRNA-splicing factor 18
  • 2dk4 – hPrp splicing factor motif domain - NMR
    
  • 1dvk – yPrp functional domain
    
• Pre-mRNA-splicing factor 19
  • 3lrv – yPrp WD40 domain
    
  • 2bay – yPrp U-box
    
  • 1n87 - yPrp U-box - NMR
    
• Pre-mRNA-splicing factor 20
  • 2i38 - hPrp RNA-binding domain (mutant) – NMR
    
  • 2i2y – Prp RNA-binding domain + RNA – Streptococcus – NMR
    
• Pre-mRNA-splicing factor 21
  • 4dgw – yPrp + Prp 9 + Prp 11
• snRNA-associated-splicing factor 24
  • 2l9w – yPrp C terminal – NMR
    
  • 2kh9 – yPrp residues 115-197 + RNA – NMR
    
  • 2go9 – yPrp RNA-binding domains – NMR
    
  • 2ghp - yPrp RNA-binding domains
• Pre-mRNA-splicing factor 31
  • 2ozb – hPrp + RNA + tri-snRNP
    
  • 3siu, 3siv – hPrp + NHP2-like protein + snRNP
    
• Pre-mRNA-splicing factor 38A
  • 4rz9, 4rza – hPrp
    
  • 5f5s – hPrp + microfibrillar-associated protein 1
    
• Pre-mRNA-splicing factor 40
  • 1o6w – yPrp WW domain - NMR
    
  • 2b7e – yPrp FF1 domain - NMR
    
  • 2kfd – yPrp FF4 domain - NMR
    
• Pre-mRNA-splicing factor 43P
  • 2xau, 3kx2 – yPrp + ADP
• Pre-mRNA-splicing factors in spliceosome
  • 3jcr, 5o9z, 6id1, 6id0, 6icz, 6ff7, 6ff4, 6ah0, 5z58, 6qdv, 6qw6, 6qx9, 6y50, 6y53, 6y5q, 6zym, 7a5p, 7aav, 7abf, 7abg, 7abh, 7abi, 7dvq, 7onb – hPrp - CryoEM
    
  • 3jb9 – yPrp
    
  • 3jcm, 5gam, 5gan, 5gao, 5gap, 5gmk, 5lj3, 5lj5, 5lqw, 5mps, 5mq0, 5mqf, 5wsg, 6g90, 6exn, 6bk8, 5ylz, 5y88, 6j6q, 6j6n, 6j6h, 6j6g, 5zwo, 7b9v, 7dco, 7oqb, 7oqe – yPrp - CryoEM
    
• Pre-mRNA-splicing factor cwc2
  • 3tp2, 3u1l, 3u1m – yPrp
    
• Pre-mRNA-splicing factor cwc26
  • 2mkc – yPrp + U2 SNRNP component IST3 + Pre-mRNA leakage protein
    
  • 4uqt – yPrp + U2 SNRNP component IST3
    
• Pre-mRNA-splicing factor bud31
  • 2my1 – yPrp - NMR
    
• Pre-mRNA-splicing factor cef1
  • 6jui – Prp – rice fungus
    
• Pre-mRNA-splicing factor sad1
  • 4msx – yPrp
    
• Pre-mRNA-splicing factor RBM22
  • 2ytc – yPrp RNA-binding domain - NMR
    
• Pre-mRNA-splicing factor RDS3
  • 2k0a – yPrp - NMR
    
• Pre-mRNA-splicing factor URN1
  • 2juc – yPrp FF domain - NMR
    

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Michal Harel