Transducin 3D structures

3D structures of transducin

Updated on 15-May-2022 - For a general description of the protein see Transducin

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• Transducin-α
  • 7bph – hTDN + GN13 + GPPNP - human
    
  • 1tnd – bTDN + GTPγS - bovine
    
  • 1tag – bTDN + GDP
    
  • 3v00 – b/ratTDN + GDP
    
  • 1tad – bTDN + GDP + AlF4
    
  • 1fqk – bTDN + RGS9 + GDP + AlF4
    
  • 1fqj – bTDN + RGS9 + GMP-PDE γ + GDP + AlF4
    
  • 7jsn – bTDN (mutant) + phosphodiesterase + GTP + Levitra – Cryo EM
    
• Transducin-b
  • 7ewp, 7ewr – hTDN + RGS7 + GPR158
    
  • 6n9g – mTDN + RGS7 - mouse
    
  • 7shf – mTDN + RGS7 – Cryo EM
    
• Transducin-βγ
  • 5he0, 5he1, 5he2, 5he3, 7k7z, 7k7l, 7pwd – hTDN + β-adrenergic receptor kinase 1 + inhibitor
    
  • 4kfm – hTDN + G-protein activated inward rectifier K+ channel
    
  • 6m8s – hTDN + KCTD12
    
  • 7sf7, 7fs8 – hTDN + adhesion GPC receptor + G protein subunit 13 – Cryo EM
    
  • 6nbi, 6nbh, 6nbf – hTDN + PTH/PTHRP + long-acting parathyroid hormone + GS protein a subunit + nanobody – Cryo EM
    
  • 1tbg – bTDN
    
  • 2trc, 1a0r, 1b9x, 1b9y – bTDN + phosducin
    
  • 1omw, 3cik – bTDN + G-protein coupled receptor kinase 2
    
  • 3v5w – bTDN (mutant) + G-protein coupled receptor kinase 2
    
  • 3psc, 3pvu, 3pvw, 4mk0 – bTDN + β-adrenergic receptor kinase 1
    
  • 6u7c, 6c2y, 5ukk, 5ukl, 5ukm – bTDN + β-adrenergic receptor kinase 1 + inhibitor
    
  • 4pnk – TDN hb + bc (mutant)+ β-adrenergic receptor kinase 1 + inhibitor
    
  • 2bcj – bTDN (mutant) + β-adrenergic receptor kinase 1
    
  • 3uzs – bTDN + β-adrenergic receptor kinase 1 + RNA
    
  • 3krw, 3krx, 5wg5, 5wg4, 5wg3 – bTDN + G-protein coupled receptor kinase 2 + inhibitor
    
  • 1xhm – bTDN + peptide
    
  • 6pcv – bTDN + RAC exchanger – Cryo EM
    
  • 6b20 – bTDN + nanobody
    
  • 6rmv – mTDN + channel peptide
    
• Transducin-α+βγ binary complex
  • 6eg8 – hTDN + GDP
    
  • 6d9h – hTDN + AChR/adenosine receptor – Cryo EM
    
  • 6g79, 7e2x, 7e32, 7e33 – hTDN + serotonin receptor – Cryo EM
    
  • 7d76, 7wu4, 7wu5 – hTDN + adhesion GPC receptor – Cryo EM
    
  • 7mts – hTDN + glutamate receptor – Cryo EM
    
  • 7vh0 – hTDN + melatonin receptor – Cryo EM
    
  • 7f1q, 7f1r, 7f1s – hTDN + chemokine receptor – Cryo EM
    
  • 7fig, 7fih, 7fii – bTDN + leutinizing hormone/choriogonadotropin receptor – Cryo EM
    
  • 1got – bTDN + GDP
    
• Transducin-α+βγ ternary complex
  • 6ddf, 6dde – hTDN + mu opioid receptor + DAMGO – Cryo EM
    
  • 6p9x – hTDN + CRFR-1 + corticliberin – Cryo EM
    
  • 6osa – hTDN + NTR1 + JMV449 – Cryo EM
    
  • 7e2z – hTDN + serotonin receptor + drug – Cryo EM
    
  • 7e2y – hTDN + serotonin receptor + serotonin – Cryo EM
    
  • 7l0p, 7l0q, 7l0r, 7l0s – hTDN + neurotensin receptor + neurotensin – Cryo EM
    
  • 7lci – hTDN + glucagon-like peptide receptor + inhibitor – Cryo EM
    
  • 7f1r, 7f1s – hTDN + chemokine receptor – Cryo EM
    
  • 7mby – hTDN + cholecystokinin receptor + cholecystokinin – Cryo EM
    
  • 7f6i – hTDN + bradykinin receptor + kallidin + cholesterol – Cryo EM
    
  • 7f6h – hTDN + bradykinin receptor + bradykinin + cholesterol – Cryo EM
    
  • 7eib – hTDN + bradykinin receptor + polypeptide – Cryo EM
    
  • 7f8w – hTDN + cholecystokinin receptor + gastrin – Cryo EM
    
  • 7t6u, 7t6v, 7t6t, 7wvv, 7wvw – hTDN + formyl peptide receptor + peptide agonist – Cryo EM
    
  • 7wvy – hTDN + formyl peptide receptor + amyloid-beta A4 – Cryo EM
    
  • 7wvx – hTDN + formyl peptide receptor + humanin – Cryo EM
    
  • 7ld4 – hTDN + adenosine A2A receptor + adenosine – Cryo EM
    
  • 7ld3 – hTDN + adenosine A2A receptor + adenosine + agonist – Cryo EM
    
  • 7td3 – hTDN + sphingosine receptor + sphingosine – Cryo EM
    
  • 7td4 – bTDN + sphingosine receptor + drug – Cryo EM
    
  • 6oy9 – bTDN + rhodopsin + retinal – Cryo EM
    
  • 7s0f, 7s0g – bTDN + adrenergic receptor + drug – Cryo EM
    
  • 7td0, 7td1, 7td2 – bTDN + lysophosphatidic receptor + lysophosphatidic acid – Cryo EM
    
  • 1gg2 – rTDN (mutant) + bbc + GDP - rat
    
  • 1gp2, 5kdo – rTDN + bbc + GDP
    
  • 3ah8 – rTDN + bb + bc (mutant) + GDP + inhibitor
    
  • 5tdh – h/rTDN (mutant) + rb + bc + GDP
    
• Transducin-α+βγ ternary complex with scFv
  • 6pt0, 6n4b, 6kpg, 6kpf – hTDN + cannaboid receptor + scFv – Cryo EM
    
  • 6oik, 6oij – hTDN + AChR + scFv – Cryo EM
    
  • 6crk – hTDN + scFv
    
  • 6vms, 7cmu, 7cmv – r/hTDN + dopamine receptor + scFv
    
  • 7d77, 7tuz – hTDN + adhesion GPC receptor + scFv – Cryo EM
    
  • 7ezh – hTDN + cholecystokinin receptor + scFv – Cryo EM
    
  • 7exd – hTDN + serotonin receptor + scFv – Cryo EM
    
  • 7evy, 7evz, 7ew0, 7ew1, 7ew2, 7ew3, 7ew4, 7ew7 – hTDN + S1P receptor + scFv – Cryo EM
    
  • 7vkt – hTDN + leukotriene B4 receptor + scFv – Cryo EM
    
  • 7wvu – hTDN + formyl peptide receptor + scFv + formyl peptide – Cryo EM
    
  • 6omm, 7t6s – hTDN + formyl peptide receptor + scFv + agonist – Cryo EM
    
  • 6k41, 6k42 – hTDN + adrenergic receptor + scFv – Cryo EM
    
  • 6wwz, 7vl8 – hTDN + chemokine receptor + scFv – Cryo EM
    
  • 7eb2 – hTDN + GABA receptor + scFv – Cryo EM
    
  • 7db6 – hTDN + melatonin receptor + scFv – Cryo EM
    
  • 7jhj – hTDN + BILF1 + scFv – Cryo EM
    
  • 7l1u – hTDN + orexin receptor + scFv – Cryo EM
    
  • 7e9h – hTDN + glutamate receptor + scFv – Cryo EM
    
  • 7v68, 7v69 – hTDN + muscarinic acetylcholine receptor + scFv – Cryo EM
    
  • 6wha – hTDN + hydroxytryptamine receptor + scFv – Cryo EM
    
  • 6xbk, 6xbj, 6xbl, 6xbm – hTDN + smoothened homolog + scFv – Cryo EM
    
  • 3sn6 – TDN ba (mutant) + rb (mutant) + bc + endolysine + scFv
    
• Transducin-α+βγ ternary complex with nanobody
  • 7ept, 7wuq – hTDN + adhesion GPC receptor + nanobody – Cryo EM
    
  • 6ni3 – hTDN + endolysin/adrenergic receptor + nanobody – Cryo EM
    
  • 7f16 – hTDN + PTH2 receptor + nanobody – Cryo EM
    
  • 7c2e, 7duq, 7dur, 7e14, 7evm, 7s3i – hTDN + glucagon-like peptide receptor + nanobody – Cryo EM
    
  • 7evw – hTDN + frizzled-7 + minGas + nanobody – Cryo EM
    
  • 7dh5 – hTDN + adrenergic receptor + nanobody – Cryo EM
    
  • 7cx2, 7cx3, 7cx4 – hTDN + prostaglandin receptor + nanobody – Cryo EM
    
  • 7f4d, 7f4f, 7f4h, 7f4i, 7f58 – hTDN + melanocortin receptor + nanobody – Cryo EM
    
  • 7ljd – hTDN + dopamine receptor + nanobody – Cryo EM
    
  • 7v9l – hTDN + GHRH receptor + nanobody – Cryo EM
    
  • 6p9y, 6lpb, 6m1i – hTDN + PACAP + nanobody – Cryo EM
    
  • 6li3 – hTDN + GPR52 + nanobody – Cryo EM
    
  • 6gdg – hTDN + adenosine A2A receptor + nanobody – Cryo EM
    
  • 7bw0, 7cfm, 7cfn – hTDN + bile acid receptor + nanobody – Cryo EM
    
  • 5uz7 – hTDN + calcitonin receptor + nanobody – Cryo EM
    
  • 7c2e – hTDN + glucagon receptor + nanobody – Cryo EM
    
  • 7d7m – hTDN + prostaglandin receptor + nanobody – Cryo EM
    
  • 7bz2 – h/bTDN + adrenergic receptor + nanobody – Cryo EM
    
  • 7jjo – bTDN + adrenergic receptor + nanobody – Cryo EM
    
• Transducin-α+βγ ternary complex with antibody
  • 7o7f – hTDN + chemokine receptor + antibody – Cryo EM
    
  • 6ot0 – hTDN + antibody + smoothened homolog – Cryo EM
    
  • 6cmo – hTDN + antibody + rhodopsin/cytochrome b562 – Cryo EM
    
• Transducin-α+βγ quaternary complex with scFv
  • 6os9 – hTDN + NTR1 + JMV449 + scFv – Cryo EM
    
  • 6lfm, 6lfo – hTDN + chemokine receptor + IL8 + scFv – Cryo EM
    
  • 7l1v – hTDN + orexin receptor + scFv + nanobody – Cryo EM
    
  • 7sbf, 7scg, 7u2l – hTDN + mu opioid receptor + scFv + ligand – Cryo EM
    
  • 7dfl – hTDN + histamin receptor + scFv + histamin – Cryo EM
    
  • 7ryc – hTDN + oxytocin receptor + scFv + oxytocin – Cryo EM
    
  • 7vl9, 7vla – hTDN + chemokine receptor + scFv + CCL15 – Cryo EM
    
  • 7t6b, 7wf7 – hTDN + sphingosine receptor + scFv + sphingosine – Cryo EM
    
  • 7eo2, 7eo4 – hTDN + sphingosine receptor + scFv + agonist – Cryo EM
    
  • 7f2o – hTDN + bradykinin receptor + scFv + polypeptide – Cryo EM
    
  • 7aue – hTDN + melatonin receptor + scFv + aminoserine – Cryo EM
    
  • 7vgy, 7vgz – hTDN + melatonin receptor + scFv + cholesterol + drug – Cryo EM
    
  • 7w53, 7w55, 7w56, 7w57 – hTDN + neuromedin receptor + scFv + neuromedin – Cryo EM
    
  • 6xox, 7rg9 – hTDN + glucagon-like peptide receptor + scFv + nanobody – Cryo EM
    
  • 7rgp – hTDN + glucagon-like peptide receptor + scFv + nanobody + polypeptide – Cryo EM
    
  • 7dw9 – hTDN + vasopressin receptor + scFv + nanobody + polypeptide – Cryo EM
    
  • 7ezk, 7ezm – hTDN + cholecystokinin receptor + cholecystokinin + scFv – Cryo EM
    
  • 7f8w – hTDN + cholecystokinin receptor + gastrin + scFv – Cryo EM
    
  • 7ej0, 7ej8, 7eja, 7ejk – hTDN + adrenergic receptor + scFv + drug – Cryo EM
    
  • 7rkx, 7rky – hTDN + GPC receptor + scFv + GDP – Cryo EM
    
  • 7rkf, 7rkm, 7rkn – hTDN + GPC receptor + scFv + fractalkine – Cryo EM
    
  • 7ejx, 7vug – hTDN + GPC receptor + scFv + ligand – Cryo EM
    
  • 7na7, 7w2z – hTDN + ghrelin receptor + scFv + gherlin – Cryo EM
    
  • 7e9g – hTDN + glutamate receptor + scFv + DN13 – Cryo EM
    
  • 7p00, 7p02 – hTDN + substance P receptor + scFv + substance P – Cryo EM
    
  • 7t11 – hTDN + somatostatin receptor + scFv + octreotide – Cryo EM
    
  • 7t10 – hTDN + somatostatin receptor + scFv + somatostatin – Cryo EM
    
  • 7s8o – hTDN + MAS-related receptor + scFv + ligand – Cryo EM
    
  • 7vdh, 7vdl, 7vdm, 7vuy, 7vuz, 7vv3, 7vv5 – hTDN + MAS-related receptor + scFv + cholesterol + ligand – Cryo EM
    
  • 7s8m – hTDN + MAS-related receptor + scFv + cortistatin – Cryo EM
    
  • 7v6a – hTDN + muscarinic acetylcholine receptor + scFv + piperidine derivative – Cryo EM
    
  • 7jvr – hTDN + dopamine receptor + ligand + scFv – Cryo EM
    
• Transducin-α+βγ quaternary complex with nanobody
  • 6pb1, 6pb0 – hTDN + CRFR-2 + urocortin + nanobody – Cryo EM
    
  • 6niy, 6e3y, 7tyi, 7tyn, 7tyo – hTDN + calcitonin receptor + calcitonin + nanobody – Cryo EM
    
  • 7tyw – hTDN + calcitonin receptor + calcitonin + receptor activity-modifying protein + nanobody – Cryo EM
    
  • 6vn7 – hTDN + VIP-1 receptor + PACAP + nanobody – Cryo EM
    
  • 6m1h – hTDN + PAC1 receptor + maxadilan + nanobody – Cryo EM
    
  • 7d3s, 6wi9, 6wzg – hTDN + secretin receptor + secretin + nanobody – Cryo EM
    
  • 6whc – hTDN + glucagon receptor + dual-agonist peptide + nanobody – Cryo EM
    
  • 6lmk, 6lml, 6x1a, 6x19, 6x18, 6wpw, 5vai, 6vcb – hTDN + glucagon receptor + glucagon + nanobody – Cryo EM
    
  • 7cz5 – hTDN + growth hormone-releasing hormone receptor + somatoliberin + nanobody – Cryo EM
    
  • 6uva, 6uun, 6uus – hTDN + receptor activity-modifying protein + ADM2 + CGRP receptor + nanobody – Cryo EM
    
  • 6b3j – hTDN + GLP-1R + exendin-p5 + nanobody – Cryo EM
    
  • 7wq3, 7wq4 – hTDN + galanin receptor + nanobody + galanin – Cryo EM
    
  • 7f53, 7f54, 7f55, 7piu, 7piv – hTDN + melanocortin receptor + nanobody + peptide agonist – Cryo EM
    
  • 7vgx – hTDN + neuropeptide receptor + nanobody + neuropeptide agonist – Cryo EM
    
  • 7dty – hTDN + insulinotropic receptor + gastric inhibitory polypeptide + nanobody – Cryo EM
    
  • 7bb6, 7bb7 – hTDN + vasopressin receptor + vasopressin + nanobody – Cryo EM
    
  • 7ki0, 7ki1, 7d68, 7rtb, 7s1m – hTDN + glucagon-like peptide receptor + nanobody + glucagon derivative – Cryo EM
    
  • 7lll – hTDN + glucagon-like peptide receptor + nanobody + exendin – Cryo EM
    
  • 7fim, 7lly, 7v35, 7vbh, 7vbi – hTDN + glucagon-like peptide receptor + nanobody + polypeptide – Cryo EM
    
  • 7mbx – hTDN + cholecystokinin receptor + cholecystokinin + nanobody – Cryo EM
    
  • 7bz2, 7dhi, 7dhr – hTDN + adrenergic receptor + nanobody + agonist – Cryo EM
    
  • 7xjh, 7xji – hTDN + adrenergic receptor + nanobody + drug – Cryo EM
    
  • 7vuh, 7vui, 7vuj – hTDN + GPC receptor + nanobody + ligand – Cryo EM
    
  • 7f9y, 7f9z, 7na8 – hTDN + ghrelin receptor + nanobody + pyrazole derivative – Cryo EM
    

P receptor + scFv + substance P – Cryo EM

• • 7rmg, 7rmh, 7rmi – hTDN + substance P receptor + nanobody + substance P – Cryo EM
    
  • 7v9m – hTDN + GHRH receptor + nanobody + somatoliberin – Cryo EM
    
  • 7tyl – hTDN + calcitonin receptor + nanobody + amylin peptide – Cryo EM
    
  • 7tyf, 7tyh, 7tyx, 7tyy, 7tzf – hTDN + calcitonin receptor + nanobody + amylin peptide + receptor activity-modifying protein - Cryo EM
    
  • 7fin, 7fiy, 7ra3, 7vab – hTDN + GIP receptor + nanobody + polypeptide – Cryo EM
    
  • 7cky, 7crh, 7jv5, 7jvp, 7jvq – hTDN + dopamine receptor + ligand + nanobody – Cryo EM
    
• Transducin-α+βγ quaternary complex with scFv and nanobody
  • 7rbt – hTDN + GIP receptor + nanobody + scFv + polypeptide – Cryo EM
    
  • 7joz – hTDN + dopamine receptor + scFv + nanobody
    
  • 7wu2, 7wu3, 7wui, 7wuj – hTDN + adhesion GPC receptor + scFv + nanobody – Cryo EM
    
  • 7ckw, 7ckx, 7ckz, 7ljc – hTDN + dopamine receptor + scFv + nanobody – Cryo EM
    
  • 7kh0 – hTDN + vasopressin receptor + vasopressin + scFv + nanobody – Cryo EM
    
• Transducin-α+βγ quaternary complex with antibody
  • 6qno – h/bTDN + antibody + rhodopsin + retinal – Cryo EM
    
  • 6oya – bTDN + antibody + rhodopsin + retinal – Cryo EM
    

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Michal Harel, Jaime Prilusky