3a7e | pdb_00003a7e

Crystal structure of human COMT complexed with SAM and 3,5-dinitrocatechol

spinqualitylabelsall models 3a7e, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3a7e is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.8Å Ligands: DNC, MG, SAM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function COMT_HUMAN Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Catechol O-methyltransferase Catechol O-methyltransferase 3D structures

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