4ejx | pdb_00004ejx

Structure of ceruloplasmin-myeloperoxidase complex

spinqualitylabelsall models 4ejx, resolution 4.69Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ejx is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 4.69Å Ligands: BMA, CU, HEM, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease CERU_HUMAN Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances. Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2. Function CERU_HUMAN Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity). See Also Ceruloplasmin Myeloperoxidase Sandbox WWC11

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