Caspase 3D structures

3D structures of caspase

Updated on 15-January-2025

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• CASP-1
  • 8wra – h-CASP - human
    
  • 3e4c – hpro-CASP (mutant)
    
  • 5fna – hCASP CARD domain – Cryo-EM
    
  • 1sc1, 1sc4 - hCASP (mutant)
    
  • 1sc3 - hCASP (mutant) + malonate
    
  • 6bz9 - hCASP + polypeptide inhibitor
    
  • 1ibc, 3d6f, 3d6h, 3d6m, 5mmv, 5mtk, 6f6r - hCASP (mutant) + polypeptide inhibitor
    
  • 1bmq, 2hbq, 3ns7 - hCASP + inhibitor
    
  • 1rwk, 1rwm, 1rwn, 1rwo, 1rwp, 1rwv, 1rww, 1rwx, 2fqq, 2h48, 2h4w, 2h4y, 2h51, 2h54, 2hbr, 2hby, 2hbz - hCASP (mutant) + inhibitor
    
  • 1ice – hCASP + tetrapeptide aldehyde
    
  • 6vie – hCASP + gasdermin
    
  • 6kn0 – hCASP (mutant) + gasdermin
    
  • 6pzp – hCASP + VX-765
    
  • 7keu – hCASP CARD domain 2-86 + ASC CARD domain – Cryo-EM
    
  • 8sv1 – hCASP subunits p10, p20 + interleukin-18 – Cryo-EM
    
  • 2nn3 – pro-SfCASP (mutant) – Spodoptera frugiperda
    
  • 1m72 – SfCASP + polypeptide inhibitor
    
• CASP-2
  • 2p2c – hCASP
    
  • 3r7s - hCASP subunits P12, P18
    
  • 1pyo, 3r5j, 3r6g, 3r6l, 3r7b, 3r7n, 3rjm - hCASP + polypeptide inhibitor
    
• CASP-3
  • 1qx3 - hCASP
    
  • 2xyg, 2xyh, 2xyp, 4jje – hCASP subunits P12, P17 + inhibitor
    
  • 2xzd, 2xzt, 2y0b - hCASP subunits P12, P17 + DARPIN-3.4
    
  • 1cp3, 1pau, 2cdr, 2cnk, 2cnl, 2cnn, 2cno, 2h65, 3edq, 3edr, 3gjq, 3gjr, 3gjs, 3gjt, 3pcx, 3pd0, 3pd1, 4pry – hCASP + polypeptide inhibitor
    
  • 4dcj, 4dco, 4dcp, 4eha, 4ehd, 4ehf, 4ehh, 4ehk, 4ehl, 4ehn, 4ps0, 4ps1, 6ckz, 6x8i, 7rn7, 7rn8, 7rn9, 7rna, 7rnb, 7rnc, 7rnd, 7rne, 7rnf, 7rng, 7seo, 7uso, 7usp, 7usq – hCASP subunits P12, P17 + polypeptide inhibitor
    
  • 2cjx, 2cjy, 2dko, 4qtx, 4qty, 4qu0, 4qu5, 4qu8, 4qu9, 4qua, 4qub 4qud, 4qud, 4que, 4qug, 4quh, 4qui, 4quj, 4qul, 5i9b, 5i9t, 5iab, 5iae, 5iag, 5iaj, 5iak, 5ian, 5iar, 5ias, 5ibc, 5ibp, 5ibr, 6bdv, 6bfj, 6bfk, 6bfl, 6bfo, 6bg0, 6bg1, 6bg4, 6bgk, 6bgq, 6bgr, 6bgs, 6bh9, 6bha - hCASP (mutant) + polypeptide inhibitor
    
  • 1gfw, 1nme, 1nmq, 1nms, 1re1, 1rhj, 1rhk, 1rhm, 1rhq, 1rhr, 1rhu, 3deh, 3dei, 3dej, 3dek, 3h0e, 3kjf – hCASP + inhibitor
    
  • 2c1e, 2c2k, 2c2m, 2c2o, 2c2z, 2h5i, 2h5j, 2j30, 2j31, 2j32, 2j33, 3itn, 4jr0 – hpro-CASP + polypeptide inhibitor
    
  • 4jqy, 4jqz - hpro-CASP (mutant)
    
  • 1i3o - hCASP (mutant) + XIAP-BIR2
    
  • 7wr6 - hCASP (mutant) + ADPR-glycohydrolase
    
  • 7xn4 - hCASP + CopC + calmodulin + nicotinamide – Cryo EM
    
  • 7xn5, 7xn6, 8e2j - hCASP + CopC + calmodulin + ADPR + nicotinamide – Cryo EM
    
  • 6wi4 – CASP + inhibitor – Porites asteroides
    
• CASP-4
  • 6nry – hCASP
    
  • 7wr0 – hCASP (mutant)
    
  • 6kmz – hCASP (mutant) + gasdermin
    
  • 7wr1 – hCASP + Ospc3 C-terminal
    
  • 7wr4, 7wr5 – hCASP (mutant) + calmodulin + Ospc3
    
  • 8j6k, 8spb – hCASP subunits p10, p20 + interleukin-18 – Cryo-EM
    
  • 6kmt, 6kmu, 6kn1 – mCASP (mutant) - mouse
    
  • 6kmv – mCASP (mutant) + gasdermin
    
• CASP-6
  • 2wdp, 3k7e, 3p45 – hCASP
    
  • 3nkf, 3nr2, 3s8e, 3v6l, 3v6m, 4iyr, 6deu, 6dev – hCASP (mutant)
    
  • 3od5, 3p4u, 3qnw, 3s70 – hCASP + polypeptide inhibitor
    
  • 4ejf – hCASP subunit P11 + P18 + polypeptide
    
  • 4fxo - hCASP subunit P11 + P18 + Zn
    
  • 4hva - hCASP subunit P11 + P18 + VEID inhibitor
    
  • 4n5d, 8eg5, 8eg6 - hCASP subunit P11 + P18 + inhibitor
    
  • 6ppm - hCASP subunit P11 + P18 + polypeptide inhibitor
    
  • 4n6g, 4n7j, 4n7m, 4nbk, 4nbl, 4nbn - hCASP subunit P11 + P18 (mutant) + inhibitor
    
• CASP-7
  • 3rk5, 4fdl - hCASP
    
  • 5k20 – hCASP large + small (mutant) subunits
    
  • 3ibf – hCASP large subunit
    
  • 3r5k, 4hq0 - hCASP (mutant)
    
  • 1gqf, 1k86 – hCASP catalytic domain
    
  • 1k88 – hpro-CASP (mutant)
    
  • 2ql5, 2ql7, 2ql9, 2qlb, 2qlf, 2qlj, 3edr, 3ibc - hCASP large subunit + polypeptide inhibitor
    
  • 1f1j, 4hqr - hCASP + polypeptide inhibitor
    
  • 6x8j, 6x8k, 6x8l - hCASP subunits p11, p20 + polypeptide inhibitor
    
  • 8dgz - hCASP + peptide + inhibitor
    
  • 7wzs – hCASP + calmodulin + CopC
    
  • 3h1p, 4jr1, 4jr2 - hCASP catalytic domain (mutant) + polypeptide inhibitor
    
  • 1shj, 1shl - hCASP catalytic domain (mutant) + inhibitor
    
  • 4fea, 5v6u, 5v6z, 8dj3 - hCASP catalytic domain + inhibitor
    
  • 1i51, 1kmc - hCASP (mutant) + XIAP-BIR2
    
  • 1i4o - hCASP P20 subunit + XIAP
    
  • 4jb8, 4lsz - hCASP large+small subunits + DARPIN
    
  • 4zvo, 4zvp, 4zvq, 4zvr, 4zvs, 4zvt, 4zvu, 5ic6, 5ic4, 6cl0, 6cl1, 6cl2 - hCASP large+small subunits + peptide inhibitor
    
• CASP-8
  • 5l08 – hCASP – Cryo-EM
    
  • 6xkj – hCASP CARD domain 451-537 – Cryo-EM
    
  • 4zbw, 7lvj, 7lvm - hCASP death effector domain
    
  • 5h31, 5h33 - hCASP death effector domain (mutant)
    
  • 6agw - hCASP pro domain 1-180
    
  • 3kjn, 3kjq – hCASP subunit P18 + inhibitor
    
  • 1f9e, 1qdu, 1qtn - hCASP subunit α,β + polypeptide inhibitor
    
  • 1qtn, 4jj7, 4jj8, 4prz - hCASP P18, P11 + polypeptide inhibitor
    
  • 3h11 - hCASP (mutant) + polypeptide inhibitor
    
  • 2y1l - hCASP subunits P18 P10
    
  • 6x8h - hCASP P18, P10 + polypeptide inhibitor
    
  • 8ym4, 8ym5, 8ym6, 8ynk, 8ynm, 8ynn - hCASP subunit P10 + apoptosis regulator – Cryo EM
    
  • 8ybx, 8yd7, 8yd8, 8yni - hCASP (mutant) + apoptosis regulator + FADD – Cryo EM
    
  • 6px9 - hpro-CASP catalytic domain 276-538 + inhibitor
    
  • 2k7z – hpro-CASP catalytic domain (mutant) – NMR
    
  • 1i4e, 2fun – CASP + P35 – Autographa californica
• CASP-9
  • 2ar9 – hCASP (mutant)
    
  • 1jxq - hCASP + polypeptide inhibitor
    
  • 3v3k – hCASP + effector protein
    
  • 5juy, 5wvc, 5wve – hCASP CARD domain + APAF-1
    
  • 1nw9 – hCASP catalytic domain + XIAP-BIR3
    
  • 3ygs, 4rhw – hpro-CASP + APAF-1 CARD
• CASP-11
  • 6ns7 – mCASP 60-243
    
  • 6kxg – mCASP CARD domain 1-463
    
• Drosophila melanogaster CASP
  • 2fp3 – DmCASP Dronc residues 136-450 – Drosophila melanogaster
    
  • 8ynl - DmCASP DronC residues 10-111 + Dark
    
  • 3sir - DmCASP drICE residues 78-332
    
  • 3sip – DmCASP drICE residues 78-230 + apoptosis inhibitor
    
• Metacaspase
  • 4af8, 4afp, 4afr, 4afv – MCASP (mutant) – Trypanosom brucei
    
  • 4f6o – yMCASP 1 – yeast
    
  • 4f6p – yMCASP 1 (mutant)
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel