Interleukin 3D structures

3D structures of interleukin

Updated on 05-October-2025

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• IL-1 α
  • 2ila - hIL-1 α - human
    
  • 2kki - hIL-1 α residues 121-271
    
  • 2l5x – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR
    
• Mature IL-1 β (residues 117-269)
  • 1i1b, 1iob, 2i1b, 2nvh, 3ltq, 4ilb, 5i1b, 8rys, 9i1b - hIL-1 β
  • 3ltq, 8rys - hIL-1 β
    
  • 6i1b, 7i1b - hIL-1 β - NMR
    
  • 1hib, 1l2h, 1s0l, 1t4q, 1tp0, 1too, 1twe, 1twm, 21bi, 31bi, 3pok, 41bi - hIL-1 β (mutant)
    
  • 6y8i, 6y8m, 8c3u, 8rzb - hIL-1 β + pyridine derivative
    
  • 8ryk - hIL-1 β + peptide
    
  • 1itb - hIL-1 β + IL-1 receptor 1 extracellular domain
    
  • 3o4o - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein
    
  • 4dep - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein
    
  • 4g6j, 4g6m, 5bvp, 7chy, 7chz, 7z4t - hIL-1 β + antibody
    
  • 2kh2 - hIL-1 β + scFv - NMR
    
  • 2mib, 8i1b - mIL-1 β - mouse
  • 2wry - cIL-1 β – chicken
    
  • 3nj5, 4x37, 4x38, 4x39, 4x3a – cIL-1 β (mutant)
    
• IL-2 (T-cell growth factor)
  • 1m47, 1m4c, 3ink – hIL-2
    
  • 3qb1, 7m2g, 7ra9, 7raa - hIL-2 (mutant)
    
  • 1irl – hIL-2 (mutant) - NMR
    
  • 5m5e - hIL-2 + IL-2 receptor β + cytokine receptor common γ
    
  • 2erj, 2b5i - hIL-2 + IL-2 receptor α and β + cytokine receptor common γ
    
  • 1z92 - hIL-2 + IL-2 receptor α
    
  • 3qaz - hIL-2 + IL-2 receptor β and γ
    
  • 1qvn, 1nbp, 1m4a, 1m4b – hIL-2 (mutant) + inhibitor
    
  • 1pw6, 1py2, 1m48, 1m49 – hIL-2 + inhibitor
    
  • 4nej, 4nem – hIL-2 + methylfuran carboxylate derivative
    
  • 5lqb, 6ye3, 7dr4 - hIL-2 + antibody
    
  • 8sow, 8soz - hIL-2 + scFv
    
  • 7zmz - hIL-2 + CD25
    
  • 4yue - mIL-2 + antibody
    
  • 4yqx - IL-2 + antibody - rat
    
  • 4zf7 – hIL-2 - ferret
    
  • 7cjn, 7d9m – IL-2 – grass carp
    
• IL-3
  • 1jli – hIL-3 (mutant) – NMR
    
  • 6nmy – hIL-3 + IL-3 receptor α + cytokine receptor common subunit β
    
  • 5uv8, 5uwc – hIL-3 (mutant) + IL-3 receptor α
    
  • 2l3o – mIL-3 residues 33-156 (mutant) - NMR
• IL-4
  • 1hik, 1rcb, 2b8u, 2int – hIL-4
    
  • 1bbn, 1bcn, 1cyl, 1iti, 1itl, 1itm, 2cyk, 8cgf, 8ch7 – hIL-4 - NMR
    
  • 1hij, 1hzi, 2b8x, 2b8y, 2b8z, 2b90, 2b91, 2d48, 8a4f - hIL-4 (mutant)
    
  • 5fhx - hIL-4 + antibody
    
  • 1iar - hIL-4 + IL-4 receptor α (mutant)
    
  • 3bpl - hIL-4 + IL-4 receptor α + cytokine receptor common γ
    
  • 6oel - hIL-4 + IL-4 receptor α + cytokine receptor common γ + antibody
    
  • 3qb7 - hIL-4 + cytokine receptor common γ
    
  • 4ydy – hIL-4 + darpin
    
  • 3bpn - hIL-4 + IL-4 receptor α + IL-13 receptor α
• IL-5
  • 1hul – hIL-5
    
  • 3qt2 - hIL-5 + IL-5 receptor α (mutant)
    
  • 3va2 - hIL-5 + IL-5 receptor α
    
  • 8tld - hIL-5 + IL-5 receptor α + cytokine receptor subunit beta – Cryo EM
    
  • 3b5k – mIL-5
    
• IL-6
  • 1alu, 7nxz – hIL-6
    
  • 1il6, 2il6 – hIL-6 - NMR
    
  • 8qy6 – hIL-6 – Cryo EM
    
  • 1p9m - hIL-6 + IL-6 receptor α and β
    
  • 8d82, 8qy5 - hIL-6 + IL-6 receptor α and β – Cryo EM
    
  • 5fuc - hIL-6 + IL-6 receptor α + VHH6
    
  • 4j4l – hIL-6 + internalin B
    
  • 4ni7, 4ni9 – hIL-6 + nucleotide aptamer
    
  • 4cni, 4o9h, 4zs7, 8ywq – hIL-6 + antibody
    
  • 8ywr – hIL-6 42-212 + antibody
    
  • 2l3y - mIL-6 residues 27-211 - NMR
    
  • 1i16 – IL-6 + IL-6 receptor β - Herpesvirus 8
  • 8upa – sIL-6 1-56 + hIL-6 receptor β – synthetic
    
• IL-7
  • 3di2, 3di3 - hIL-7 residues 26-177 + IL-7 receptor α ectodomain
• IL-8
  • 6n2u – hIL-8
    
  • 1il8, 2il8, 5wdz – hIL-8 - NMR
    
  • 1qe6, 1icw – hIL-8 (mutant)
    
  • 1ikl, 1ikm - hIL-8 (mutant) - NMR
    
  • 3il8, 5d14, 4xdx – hIL-8 residues 28-99
    
  • 6xmn – hIL-8 residues 28-93 + CXCR1 N-terminal - NMR
    
  • 1rod - hIL-8/melanoma growth stimulating protein – NMR
    
  • 1ilp, 1ilq - hIL-8 + IL-8 receptor peptide
    
  • 6wzm – hIL-8 + antibody
    
  • 6lfm, 6lfo– hIL-8 in G-protein coupled receptor – Cryo EM
    
• IL-9
  • 7ox6 – hIL-9 - NMR
    
  • 7ox5 - hIL-9 + IL—9 receptor a
    
  • 7ox1, 7ox2, 7ox3 - hIL-9 + antibody
    
  • 7xcb – mIL-9
    
  • 7ox4 – mIL-9 + antibody
    
• IL-10
  • 2h24, 1inr, 2ilk, 1ilk – hIL-10
    
  • 1j7v – hIL-10 + IL-10 receptor α (mutant)
    
  • 1y6k - hIL-10 residues 19-178 + IL-10 receptor α
    
  • 8sve – hIL-10 + antibody
    
  • 4x51 – mIL-10
    
• IL-10 viral
  • 1vlk - hvIL-10 residues 26-170 - human herpesvirus 4
    
  • 1y6m - hvIL-10 residues 26-170 + IL-10 receptor α
    
  • 1y6n - hvIL-10 residues 26-170 (mutant) + IL-10 receptor α
    
  • 1lqs - hvIL-10 residues 20-176 + IL-10 receptor α - human herpesvirus 5
    
  • 1lk3 - hvIL-10 residues 26-175 + antibody
• IL-11
  • 4mhl - hIL-11
    
  • 8dpv, 8dpw - hIL-11 (mutant)
    
  • 8qy4 - hIL-11 (mutant) – Cryo EM
    
  • 8dpu - hIL-11 + hILR-11 alpha+beta
    
  • 8dps - hIL-11 + hILR-11 alpha+beta – Cryo EM
    
  • 8dpt - hIL-11 + hILR-11 alpha (mutant) + hILR-6 – Cryo EM
    
• IL-12
  • 1f45 - hIL-12 α and β (mutant)
    
  • 1f42 - hIL-12 β P40 domain
    
  • 3hmx - hIL-12 α and β+ antibody
    
  • 8pb1, 8yi7 - hIL-12 α and β+ hILR-12 α and β – Cryo EM
    
  • 8oe0, 8xrp – hIL-12 α and β + hIL12R beta1 and beta2 – Cryo EM
    
  • 5mj3, 5mj4, 5njd - hIL-12 β + hIL-23 α + antibody
    
  • 5mzv - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody
    
  • 6wdq - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor
    
  • 8oe4 - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor – Cryo EM
    
  • 5mxa, 8cr8 - hIL-12 β + hIL- 23 α
    

3qwr - hIL-12 β + hIL- 23 α + adnectin

• • 6uib, 8uui - hIL-12 β + hIL- 23 α + peptide
    
  • 8cr6 - mIL-12 alpha + beta subunits
    
  • 6sff, 6smc, 6sp3, 7pur, 7r3n - mIL-12 β
    
  • 8cr5 - mIL-12 alpha+β + mILR-12 beta1+ beta2 – Cryo EM
    
  • 8odz - mIL-12 β + mILR-12 beta1
    
• IL-13
  • 1ijz, 1ik0 – hIL-13 – NMR
    
  • 1ga3 - hIL-13 residues 21-132 - NMR
    
  • 3l5w, 3l5x, 3g6d, 4i77, 4ps4 - hIL-13 residues 35-146 + antibody
    
  • 3lb6 - hIL-13 + IL-13 receptor α2
    
  • 3bpo, 5e4e - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α
    
  • 5l6y, 7rew - hIL-13 + antibody
    
  • 8blq - hIL-13 + antibody – Cryo EM
    
• IL-15
  • 2xqb – hIL-15 + antibody
    
  • 2psm, 2z3q, 2z3r - hIL-15 + IL-15 receptor α
    
  • 4gs7 - hIL-15 + IL-15 receptor α + IL-2 receptor β,γ
    
• IL-16
  • 1i16 – hIL-16 - NMR
    
  • 1x6d – hIL-16 PDZ domain – NMR
    
• IL-17
  • 4hr9 - hIL-17A (mutant)
    
  • 5n92 - hIL-17A + hIL-17F
    
  • 7uwm - hIL-17A + IL-17A receptor α – Cryo EM
    
  • 4hsa - hIL-17A (mutant) + IL-17A receptor α
    
  • 5nan - hIL-17A + hIL-17F + IL-17A receptor α
    
  • 7uwn - hIL-17A + IL-17A receptor α + IL-17A receptor gamma
    
  • 7zan - hIL-17A (mutant) + IL-17A receptor α + IL-17A receptor gamma
    
  • 2vxs, 4qhu, 6wio, 6wir, 7wkx, 7z2m - hIL-17A + antibody
    
  • 8b7w, 8dy1, 8dy5 - hIL-17A + scFv
    
  • 8dyf, 8dyg, 8dyh, 8dyi, 8usr, 8uss, 9fkx, 9fl3, 9h4d, 9h4o - hIL-17A + inhibitor
    
  • 5vb9 - hIL-17A + peptide inhibitor
    
  • 8cdg - hIL-17A + macrocycle inhibitor
    
  • 7ama, 7amg - hIL-17A + modulator
    
  • 5hi5, 5hi4, 5hi3, 5hhx, 5hhv - hIL-17A + peptide inhibitor + antibody
    

1jpy, 6hgo – hIL-17F

• • 6ppg, 8ruu – hIL-17F + antibody
    

3jvf, 6hg4, 6hg9 - hIL-17F + IL-17 receptor α

• IL-18 (Interferon-γ inducing factor)
  • 3wo2 – hIL-18
    
  • 4xfs, 4xft, 4xfu, 9od7, 9od9 - hIL-18 (mutant)
    
  • 1j0s, 8urv – hIL-18 - NMR
    
  • 4hjj - hIL-18 + antibody
    
  • 2vxt - hIL-18 (mutant) + antibody
    
  • 3f62 - hIL-18 residues 37-193 (mutant) + IL-18 binding protein
    
  • 4eee, 4ekx - hIL-18 (mutant) + 14L protein
    
  • 3wo3, 4r6u - hIL-18 + IL-18 receptor
    
  • 3wo4 - hIL-18 + IL-18 receptor + IL-18 receptor accessory protein
    
  • 8j6k, 8spb, 8sv1 - hIL-18 + caspase P10, P20 subunits
    
• IL-19
  • 1n1f – hIL-19
• IL-20
  • 4doh - hIL-20 + IL-20 receptor α,β
    
• IL-21
  • 2oqp– hIL-21 – NMR
    
  • 3tgx - hIL-21 + IL-21 receptor α (mutant)
    
  • 9e2t - hIL-21 (mutant) + ILR-21 + ILR-2 gamma
    
  • 8ent - hIL-21 (mutant) + ILR-21 (mutant) + ILR-2 gamma (mutant)
    
• IL-22
  • 1ykb, 1m4r – hIL-22
    
  • 3g9v - hIL-22 residues 29-179 + IL-22 receptor α2
    
  • 3dlq, 3dgc - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1
    
  • 3q1s - hIL-22 residues 29-179 (mutant) + antibody
    
  • 6weo - hIL-22 + IL-22 receptor + IL-10 receptor
    
  • 4o6k – IL-22 – zebra fish
    
• IL-23
  • 3d87 - hIL-23 α
    
  • 3d85 - hIL-23 α + antibody
    
  • 4grw - hIL-23 α + + hIL-12 β + nanobody
    
  • 3duh - hIL-23 α + hIL-12 β
• IL-24
  • 6gg1 - hIL-24
    
  • 6df3 - hIL-24 + IL—22 receptor α1 + IL-20 receptor β
    
• IL-25
  • 7uwj, 7uwk - hIL-25 + IL—17 receptor b – Cryo EM
    
  • 7uwl - hIL-25 + IL—17 receptor a + IL—17 receptor b – Cryo EM
    
• IL-27
  • 8xwy - hIL-27 α and β
    
  • 7u7n, 8d85 - hIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM
    
  • 7zxk - hIL-27 + antibody
    
  • 7zg0 - mIL-27 + IL—27 receptor a
    
  • 7z0l - mIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM
    
• IL-28
  • 3hhc – hIL-28B
    
  • 5t5w - hIL-28B + IL—10 receptor β + IL-28 receptor α
    
• IL-29
  • 3og4, 3og6 – hIL-29 + IL-28 receptor α
• IL-33
  • 2kll - hIL-33 residues 110-270 - NMR
    
  • 4kc3 - hIL-33 + IL—1 receptor-like 1
    
  • 5iv4 - mIL-33 + IL—1 receptor-like 1 + IL-1 receptor accessory protein
    
  • 8q5r - mIL-33 + alarmin release inhibitor
    
• IL-34
  • 4dkc - hIL-34
    
  • 4dkd - hIL-34 active core + macrophage colony-stimulating factor 1 receptor
    
  • 4dke, 4dkf - hIL-34 active core + antibody
    
  • 4exn - mIL-34
    
  • 4exp - mIL-34 active core + macrophage colony-stimulating factor 1 receptor
    
• IL-36
  • 6hpi - hIL-36 α - NMR
    
  • 4ize - hIL-36 γ
    
  • 6p9e - hIL-36 γ + antagonist
    
• IL-37
  • 6ncu, 5hn1 - hIL-37
    
• IL-38
  • 8q3j - mIL-38 + antibody
    

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Michal Harel, Joel L. Sussman