6h8t

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Crystal structure of Papain modify by achiral Ru(II)complex

Structural highlights

6h8t is a 2 chain structure with sequence from Carpa. This structure supersedes the now removed PDB entry 4kp9. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:ACT, CL, NA, SO4, YXX, YXZ
NonStd Res:OMX, TXY
Activity:Papain, with EC number 3.4.22.2
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

The X-ray structure of an aerated achiral Ru-papain conjugate has revealed the hydroxylation of two tyrosine residues found near the ruthenium ion. The most likely mechanism involves a ruthenium-bound superoxide as the reactive species responsible for the first hydroxylation and the resulting high valent Ru(iv)[double bond, length as m-dash]O species for the second one.

Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate.,Cherrier MV, Amara P, Talbi B, Salmain M, Fontecilla-Camps JC Metallomics. 2018 Sep 3. doi: 10.1039/c8mt00160j. PMID:30175357[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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See Also

References

  1. ↑ Cherrier MV, Amara P, Talbi B, Salmain M, Fontecilla-Camps JC. Crystallographic evidence for unexpected selective tyrosine hydroxylations in an aerated achiral Ru-papain conjugate. Metallomics. 2018 Sep 3. doi: 10.1039/c8mt00160j. PMID:30175357 doi:http://dx.doi.org/10.1039/c8mt00160j

Contents


6h8t, resolution 2.10Å

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