Function
ATP-citrate synthase (ACS) or ATP citrate lyase or citryl-CoA synthetase is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.
See also Citrate Synthase
Citric acid cycle intermediates serve as substrates for biosynthetic processes
Reverse Krebs cycle.
Structural highlights
Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. of ATP-citrate synthase. Water molecules are shown as red spheres. , 3pff. [1]
3D Structures of ATP-citrate synthase
ATP-citrate synthase 3D structures
