Function
Phosphoglucose isomerase (PGI) or glucose-6-phosphate isomerase catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate[1]. The encoded protein is also referred to as autocrine motility factor (AMF) based on an additional function as a tumor-secreted cytokine and angiogenic factor (see Growth factors). PGI is part of the glycolysis cycle. For more details see Phosphoglucoisomerase.
Disease
Increased expression of PGI enhances colorectal cancer metastasis[2].
Structural highlights
Rabbit [3]. Water molecules are shown as red spheres.
3D Structures of phosphoglucose isomerase
Phosphoglucose isomerase 3D structures