NK cell receptor

From Proteopedia

Function Natural killer (NK) cell receptors are located on the innate immune system NK cells. The receptors are differentiated into those activating effector function and those inhibiting it. The receptors induce apoptosis upon binding ligands which indicate infection[1]. NKG2D is expressed in NK cells, cytotoxic T cells and T cell subsets. NKP are CD122(+) NK cell precursors. 2B4 (CD244) are expressed on all NK cells, T cell subset, monocytes and basophils[2]. Ly49 are lectin-type receptors expressed in NK cells and T cell subsets[3]. KIR are immunoglobulin-type receptors[4]. Relevance NKG2D is associated with response to cellular distress and infection[5].

spinqualitylabelsall models Human NK cell receptor NKG2D (grey and green) complex with class I MHC-like ligand ULBP3 (pink) and glutathione (PDB entry 1kcg) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of NK cell receptor

Updated on 20-July-2023

Activating NK cell receptors

NKG2D

1mpu – hNKG2D extracellular domain – human

1hyr, 7fi5, 7fi6, 7fi7, 7fi8, 7fi9 – hNKG2D extracellular domain + class I MHC-like ligand MICA

1kcg – hNKG2D extracellular domain + class I MHC-like ligand ULBP3

4s0u – hNKG2D extracellular domain + retinoic acid early transcript 1L protein

4pp8 – mNKG2D extracellular domain + retinoic acid early-inducible protein 1β

4pdc – hNKG2D extracellular domain + cowpox virus protein

3bdw – hNKG2D extracellular domain + CD94

3bdw, 3cii – hNKG2D extracellular domain + CD94 + MHC class I antigen E + β-2-microglobulin + HLA G antigen

8ea5, 8ea6, 8ea7, 8ea8, 8ea9, 8eaa, 8eab – hNKG2D extracellular domain + inhibitor

1hq8 – mNKG2D extracellular domain – mouse

NKp

6yjp – hNKp30 IG domain 19-130 + hNKp30 ligand

1hkf – hNKp44 IG domain

1oll, 1p6f – hNKp46 extracellular domain 25-212

2B4

1z2k – h2B4 D1 domain - NMR

2ptu – m2B4 D1 domain

2ptt – h2B4 D1 domain + CD48 antigen

Ly49

3g8l, 3g8k – mLy49 C-type lectin-like domain

CD94 See CD94

Inhibitory NK cell receptors

KIR or killer cell immunoglobulin-like receptor

3wyr – hKIR2dl4 extracellular domain

3h8n – hKIR2ds4 extracellular domain

3wuw, 5t70, 5t6z, 5b39, 5b38, 3vh8, 6v3j, 7duu, 7k80 – hKIR3dl1 extracellular domain + MHC class I antigen B + β-2-microglobulin + IG κ chain C region

6pag – hKIR3dl3 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide

6pa1 – hKIR2dl2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide

4n8v – hKIR2ds2 extracellular domain + MHC class I antigen B + β-2-microglobulin + peptide

KLRG1

3fft – hKLRG1 + cadherin

References

1. ↑ Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359-93. PMID:9597134 doi:http://dx.doi.org/10.1146/annurev.immunol.16.1.359
2. ↑ Mathew SO, Rao KK, Kim JR, Bambard ND, Mathew PA. Functional role of human NK cell receptor 2B4 (CD244) isoforms. Eur J Immunol. 2009 Jun;39(6):1632-41. doi: 10.1002/eji.200838733. PMID:19499526 doi:http://dx.doi.org/10.1002/eji.200838733
3. ↑ Kane KP, Lavender KJ, Ma BJ. Ly-49 receptors and their functions. Crit Rev Immunol. 2004;24(5):321-48. PMID:15663362
4. ↑ Norman PJ, Carrington CV, Byng M, Maxwell LD, Curran MD, Stephens HA, Chandanayingyong D, Verity DH, Hameed K, Ramdath DD, Vaughan RW. Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations. Genes Immun. 2002 Apr;3(2):86-95. PMID:11960306 doi:http://dx.doi.org/10.1038/sj.gene.6363836
5. ↑ Raulet DH. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol. 2003 Oct;3(10):781-90. PMID:14523385 doi:http://dx.doi.org/10.1038/nri1199