Image:Dhfr.movie2.gif
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Dhfr.movie2.gif (246 × 246 pixel, file size: 904 KB, MIME type: image/gif)
Summary
This is an archived copy of Michael Sawaya's DHFR movie (supplementary material to doi/10.1021/bi962337c, links no longer work), uploaded with the author's permission. The animation loop counter was set to infinite using EZgif.com.
From the original description:
Six isomorphous crystal structures of E. coli DHFR were solved (column 2 of table below), each structure analogous to a complex in the kinetic pathway (column 3 of table below). The largest motions observed correspond to M20 loop movements and subdomain movements (columns 4 & 5). These structures are depicted in the movie above in frames 01, 24, 25, 44, 51 and 56. Other frames were generated using the template forcing algorithm of the program Discover, part of a collection of programs from MSI. For further details, see Sawaya, M. R. & Kraut, J. Loop and Domain Movements in the Mechanism of E. Coli Dihydrofolate Reductase: Crystallographic Evidence. Biochemistry 1997.
Movie Frame Crystal Structure Analogue Analogous to PDB ID M20 Loop Subdomain
01 E*NH E*NH 1rx1 closed open
24 E*FOL*N+ E*DHF*NH 1rx2 closed closed
25 E*MTX*NH E*DHF*NH 1rx3 closed closed*
44 E*ddTHF*ATP-ribose E*THF*N+ 1rx4 occluded open
51 E*ddTHF E*THF 1rx5 occluded closed
56 E*ddTHF*NH E*THF*NH 1rx6 occluded open
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| Date/Time | User | Dimensions | File size | Comment | |
|---|---|---|---|---|---|
| (current) | 21:03, 5 January 2022 | Karsten Theis (Talk | contribs) | 246×246 | 904 KB | |
| 19:06, 5 January 2022 | Karsten Theis (Talk | contribs) | 246×246 | 904 KB | This is an archived copy of Michael Sawaya's DHFR movie (supplementary material to doi/10.1021/bi962337c, links no longer work), uploaded with the author's permission. From the original description: Six isomorphous crystal structures of E. coli DHFR wer |
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