Image:Positions of the mutations in PR variants used for structural studies.jpg

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Summary

Positions of the mutations in PR variants used for structural studies. (A) Each monomer of PR is used to depict the mutations in the PR_DRV1 and PR_DRV5 variants in red and blue, respectively. Mutated residues are represented with their Cα atoms (spheres) and their transparent solvent-accessible surfaces. Active-site aspartates are shown as sticks; darunavir bound to the active site is represented by sticks, and its solvent-accessible surface area is green. (B) Sequence alignment of PR_DRV1 and PR_DRV5 with the wild-type (WT) sequence. Primary mutations in residues interacting directly with darunavir are in boldface italics.

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