Nucleoporin

Function

Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD)^[1].

• NUP1P is a yeast nucleoprotein required for nuclear protein import, mRNA export and maintenance of nuclear architecture^[2].
  
• NUP2P is a yeast nucleoprotein required for bidirectional transport of importin α^[3].
  
• NUP Gle1 is a yeast and human nucleoprotein required mRNA export.
  

Disease

NUP98 and NUP214 gene translocation is associated with myeloid and lymphoid malignancies. NUP88 is over expressed in ovarian tumors. NUP214 is the functional receptor of adenovirus 2 nucleocapsids^[4].

3D Structures of Nucleoporin

Nucleoporin 3D structures