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Zanamivir, better known as Relenza, (3b7e)

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Neuraminidase Inhibitor Pharmacokinetics
Parameter Zanamivir Oseltamivir
Tmax (hr) 1.25 1.5
Cmax (ng/ml) 31.6 57
Bioavailability (%) 2 75
Protein Binding (%) 10 42
T1/2 (hr) 3 3.2
AUC (ng/ml/hr) 185 204
Clearance (L/h) 54.1 18.8
Dosage (mg) 10 300
Metabolism None Hepatic

For References to Pharmacokinetic data, see: References


  1. Varghese JN, McKimm-Breschkin JL, Caldwell JB, Kortt AA, Colman PM. The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor. Proteins. 1992 Nov;14(3):327-32. PMID:1438172 doi:
  2. Xu X, Zhu X, Dwek RA, Stevens J, Wilson IA. Structural characterization of the 1918 influenza virus H1N1 neuraminidase. J Virol. 2008 Nov;82(21):10493-501. Epub 2008 Aug 20. PMID:18715929 doi:10.1128/JVI.00959-08

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