Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1)

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Transient Receptor Potential Cation Channel Subfamily V Member 1 (TRPV1)

Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy (PDB code 3j5p)

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  1. Cao E, Liao M, Cheng Y, Julius D. TRPV1 structures in distinct conformations reveal activation mechanisms. Nature. 2013 Dec 5;504(7478):113-8. doi: 10.1038/nature12823. PMID:24305161 doi:
  2. UniProt Consortium European Bioinformatics Institute Protein Information Resource SIB SwissInstitute of Bioinformatics. (2021, February 10). Transient receptor Potential Cation CHANNEL SUBFAMILY V Member 1. Retrieved March 30, 2021, from
  3. Geppetti P, Trevisani M. Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br J Pharmacol. 2004 Apr;141(8):1313-20. doi: 10.1038/sj.bjp.0705768. Epub 2004, Mar 29. PMID:15051629 doi:
  4. Numazaki M, Tominaga T, Takeuchi K, Murayama N, Toyooka H, Tominaga M. Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):8002-6. Epub 2003 Jun 13. PMID:12808128 doi:
  5. Gunthorpe MJ, Szallasi A. Peripheral TRPV1 receptors as targets for drug development: new molecules and mechanisms. Curr Pharm Des. 2008;14(1):32-41. doi: 10.2174/138161208783330754. PMID:18220816 doi:

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