1hav
From Proteopedia
(New page: 200px<br /> <applet load="1hav" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hav, resolution 2.0Å" /> '''HEPATITIS A VIRUS 3C...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1HAV is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HAV OCA]]. | + | 1HAV is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Transferase Transferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]]. Structure known Active Sites: PRO, RNA and S1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HAV OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: thiol protease]] | [[Category: thiol protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:41:58 2007'' |
Revision as of 06:37, 30 October 2007
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HEPATITIS A VIRUS 3C PROTEINASE
Overview
The virally encoded 3C proteinases of picornaviruses process the, polyprotein produced by the translation of polycistronic viral mRNA. The, X-ray crystallographic structure of a catalytically active mutant of the, hepatitis A virus (HAV) 3C proteinase (C24S) has been determined. Crystals, of this mutant of HAV 3C are triclinic with unit cell dimensions a = 53.6, A, b = 53.5 A, c = 53.2 A, alpha = 99.1 degrees, beta = 129.0 degrees, and, gamma = 103.3 degrees. There are two molecules of HAV 3C in the unit cell, of this crystal form. The structure has been refined to an R factor of, 0.211 (Rfree = 0.265) at 2.0-A resolution. Both molecules fold into the, characteristic two-domain structure of the chymotrypsin-like serine, proteinases. The active-site and substrate-binding regions are ... [(full description)]
About this Structure
1HAV is a [Protein complex] structure of sequences from [Hepatitis a virus] with CL as [ligand]. Active as [Transferase], with EC number [2.7.7.48]. Structure known Active Sites: PRO, RNA and S1. Full crystallographic information is available from [OCA].
Reference
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition., Bergmann EM, Mosimann SC, Chernaia MM, Malcolm BA, James MN, J Virol. 1997 Mar;71(3):2436-48. PMID:9032381
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