1a4v
From Proteopedia
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| - | [[Image:1a4v.gif|left|200px]]<br /> | + | [[Image:1a4v.gif|left|200px]]<br /><applet load="1a4v" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1a4v" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1a4v, resolution 1.8Å" /> | caption="1a4v, resolution 1.8Å" /> | ||
'''ALPHA-LACTALBUMIN'''<br /> | '''ALPHA-LACTALBUMIN'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1A4V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lactose_synthase Lactose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.22 2.4.1.22] | + | 1A4V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lactose_synthase Lactose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.22 2.4.1.22] Known structural/functional Sites: <scene name='pdbsite=CB1:Ca Binding Site In The Ca-Binding-Elbow Region Is Referr ...'>CB1</scene> and <scene name='pdbsite=CB2:This Is The Secondary Ca Binding Site. At This Site The ...'>CB2</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A4V OCA]. |
==Reference== | ==Reference== | ||
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[[Category: lactose synthase]] | [[Category: lactose synthase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:08:54 2007'' |
Revision as of 11:59, 18 December 2007
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ALPHA-LACTALBUMIN
Overview
The high-resolution X-ray crystal structure of human alpha-lactalbumin (at, 1.8 A) in the presence of an elevated level of calcium reveals a new, secondary calcium binding site, 7.9 A away from the primary calcium, binding site known in all alpha-lactalbumin structures so far. The new, calcium binding site is different from the zinc and sulfate binding sites, [Ren, J., et al. (1993) J. Biol. Chem. 268, 19292-19298] but shares common, features with the manganese binding site as described by Gerkin [Gerkin, T. A. (1984) Biochemistry 23, 4688-4697]. The proximity of the manganese, and calcium binding region and the location of the functional site on one, side of the charged surface of the alpha-lactalbumin molecule suggest that, these binding sites might play a role in the formation of the lactose, synthase complex.
About this Structure
1A4V is a Single protein structure of sequence from Homo sapiens with CA as ligand. Active as Lactose synthase, with EC number 2.4.1.22 Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin., Chandra N, Brew K, Acharya KR, Biochemistry. 1998 Apr 7;37(14):4767-72. PMID:9537992
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