1hav
From Proteopedia
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1HAV is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ | + | 1HAV is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Hepatitis_a_virus Hepatitis a virus]] with CL as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48]]. Structure known Active Sites: PRO, RNA and S1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HAV OCA]]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Hepatitis a virus]] | [[Category: Hepatitis a virus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| + | [[Category: RNA-directed RNA polymerase]] | ||
[[Category: Bergmann, E.M.]] | [[Category: Bergmann, E.M.]] | ||
[[Category: James, M.N.G.]] | [[Category: James, M.N.G.]] | ||
| Line 24: | Line 25: | ||
[[Category: thiol protease]] | [[Category: thiol protease]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:40:13 2007'' |
Revision as of 08:35, 30 October 2007
|
HEPATITIS A VIRUS 3C PROTEINASE
Overview
The virally encoded 3C proteinases of picornaviruses process the, polyprotein produced by the translation of polycistronic viral mRNA. The, X-ray crystallographic structure of a catalytically active mutant of the, hepatitis A virus (HAV) 3C proteinase (C24S) has been determined. Crystals, of this mutant of HAV 3C are triclinic with unit cell dimensions a = 53.6, A, b = 53.5 A, c = 53.2 A, alpha = 99.1 degrees, beta = 129.0 degrees, and, gamma = 103.3 degrees. There are two molecules of HAV 3C in the unit cell, of this crystal form. The structure has been refined to an R factor of, 0.211 (Rfree = 0.265) at 2.0-A resolution. Both molecules fold into the, characteristic two-domain structure of the chymotrypsin-like serine, proteinases. The active-site and substrate-binding regions are ... [(full description)]
About this Structure
1HAV is a [Protein complex] structure of sequences from [Hepatitis a virus] with CL as [ligand]. Active as [RNA-directed RNA polymerase], with EC number [2.7.7.48]. Structure known Active Sites: PRO, RNA and S1. Full crystallographic information is available from [OCA].
Reference
The refined crystal structure of the 3C gene product from hepatitis A virus: specific proteinase activity and RNA recognition., Bergmann EM, Mosimann SC, Chernaia MM, Malcolm BA, James MN, J Virol. 1997 Mar;71(3):2436-48. PMID:9032381
Page seeded by OCA on Tue Oct 30 10:40:13 2007
