1a4v
From Proteopedia
(New page: 200px<br /> <applet load="1a4v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a4v, resolution 1.8Å" /> '''ALPHA-LACTALBUMIN'''...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1A4V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.22 2.4.1.22]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A4V OCA]]. | + | 1A4V is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Lactose_synthase Lactose synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.22 2.4.1.22]]. Structure known Active Sites: CB1 and CB2. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A4V OCA]]. |
==Reference== | ==Reference== | ||
Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin., Chandra N, Brew K, Acharya KR, Biochemistry. 1998 Apr 7;37(14):4767-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9537992 9537992] | Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin., Chandra N, Brew K, Acharya KR, Biochemistry. 1998 Apr 7;37(14):4767-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9537992 9537992] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Lactose synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
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[[Category: lactose synthase]] | [[Category: lactose synthase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:45:12 2007'' |
Revision as of 09:40, 30 October 2007
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ALPHA-LACTALBUMIN
Overview
The high-resolution X-ray crystal structure of human alpha-lactalbumin (at, 1.8 A) in the presence of an elevated level of calcium reveals a new, secondary calcium binding site, 7.9 A away from the primary calcium, binding site known in all alpha-lactalbumin structures so far. The new, calcium binding site is different from the zinc and sulfate binding sites, [Ren, J., et al. (1993) J. Biol. Chem. 268, 19292-19298] but shares common, features with the manganese binding site as described by Gerkin [Gerkin, T. A. (1984) Biochemistry 23, 4688-4697]. The proximity of the manganese, and calcium binding region and the location of the functional site on one, side of the charged surface of the alpha-lactalbumin molecule suggest that, these binding sites might play a role in the formation of the ... [(full description)]
About this Structure
1A4V is a [Single protein] structure of sequence from [Homo sapiens] with CA as [ligand]. Active as [Lactose synthase], with EC number [2.4.1.22]. Structure known Active Sites: CB1 and CB2. Full crystallographic information is available from [OCA].
Reference
Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin., Chandra N, Brew K, Acharya KR, Biochemistry. 1998 Apr 7;37(14):4767-72. PMID:9537992
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